{"id":"methylhexaneamine","rwe":[{"pmid":"37357012","year":"2023","title":"Unauthorized ingredients in \"nootropic\" dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"34211326","year":"2021","title":"Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.","finding":"","journal":"Journal of sports science & medicine","studyType":"Clinical Study"},{"pmid":"32099999","year":"2020","title":"The determination of common anabolic steroid and stimulants in nutritional supplements by HPLC-DAD and LC-MS.","finding":"","journal":"Journal of chromatographic science","studyType":"Clinical Study"},{"pmid":"30395850","year":"2019","title":"Methylhexaneamine causes tachycardia and pressor responses indirectly by releasing noradrenaline in the rat.","finding":"","journal":"European journal of pharmacology","studyType":"Clinical Study"},{"pmid":"28508503","year":"2017","title":"Expanding analytical options in sports drug testing: Mass spectrometric detection of prohibited substances in exhaled breath.","finding":"","journal":"Rapid communications in mass spectrometry : RCM","studyType":"Clinical Study"}],"tags":[{"label":"methylhexaneamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Nasal congestion","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"forthan","offLabel":[],"synonyms":["methylhexaneamine","1,3-dimethylpentylamine","2-amino-4-methylhexane","4-methyl-2-hexylamine","forthan","forthane"],"timeline":[],"approvals":[],"brandName":"Forthan","ecosystem":[{"indication":"Nasal congestion","otherDrugs":[{"name":"acrivastine","slug":"acrivastine","company":"Auxilium Pharms Inc"},{"name":"alimemazine","slug":"alimemazine","company":"Allergan Herbert"},{"name":"ammonium chloride","slug":"ammonium-chloride","company":"B Braun"},{"name":"antazoline","slug":"antazoline","company":"Novartis"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"methylhexaneamine","explanation":"Think of it like a 'reset button' for your nasal passages. When you breathe in Forthan, it sends a signal to your brain that says, 'Hey, it's time to reduce the swelling in your nose.' This helps to clear out excess mucus and make it easier to breathe.","oneSentence":"Forthan works by stimulating the brain's nasal congestion centers to reduce swelling and congestion.","technicalDetail":"Forthan is a sympathomimetic agent that acts as an indirect-acting adrenergic agonist, increasing the release of norepinephrine in the nasal mucosa to produce vasoconstriction and reduce nasal congestion."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3353","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=methylhexaneamine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:39:46.494387","biosimilars":[],"competitors":[],"genericName":"methylhexaneamine","indications":{"approved":[{"name":"Nasal congestion","source":"DrugCentral","snomedId":68235000,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001809","UNII":"X49C572YQO","CHEBI":"CHEBI:134754","UMLSCUI":"C3491926","PUBCHEM_CID":"7753","MESH_SUPPLEMENTAL_RECORD_UI":"C571835"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":18,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2023 Aug","pmid":"37357012","title":"Unauthorized ingredients in \"nootropic\" dietary supplements: A review of the history, pharmacology, prevalence, international regulations, and potential as doping agents.","journal":"Drug testing and analysis"},{"date":"2021 Jun","pmid":"34211326","title":"Undeclared Doping Substances are Highly Prevalent in Commercial Sports Nutrition Supplements.","journal":"Journal of sports science & medicine"},{"date":"2020 Apr 23","pmid":"32099999","title":"The determination of common anabolic steroid and stimulants in nutritional supplements by HPLC-DAD and LC-MS.","journal":"Journal of chromatographic science"},{"date":"2019 Jan 15","pmid":"30395850","title":"Methylhexaneamine causes tachycardia and pressor responses indirectly by releasing noradrenaline in the rat.","journal":"European journal of pharmacology"},{"date":"2017 Aug 15","pmid":"28508503","title":"Expanding analytical options in sports drug testing: Mass spectrometric detection of prohibited substances in exhaled breath.","journal":"Rapid communications in mass spectrometry : RCM"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Forthan, also known as methylhexaneamine, is a small molecule drug of the methylhexaneamine class. Its exact target is unknown, but it is approved for treating nasal congestion. The commercial status of Forthan is unclear, and it may be patented or have generic manufacturers. Key safety considerations are not well-documented. As a result, its use should be approached with caution.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":false,"score":2}}