{"id":"methylestrenolone","rwe":[{"pmid":"6220143","year":"1983","title":"Inhibin production by bovine ovarian tissues in vitro and its regulation by androgens.","finding":"","journal":"Journal of reproduction and fertility","studyType":"Clinical Study"},{"pmid":"144510","year":"1977","title":"Short-term and prolonged treatment with oral contraceptives and liver function.","finding":"","journal":"Arzneimittel-Forschung","studyType":"Clinical Study"},{"pmid":"4237574","year":"1968","title":"[Synthesis of current knowledge of an inhibitor of libido in the male, the methylestrenolone].","finding":"","journal":"L'Encephale","studyType":"Clinical Study"},{"pmid":"4227801","year":"1967","title":"[Action of methylestrenolone on the exploratory behavior of the male rat].","finding":"","journal":"Archives internationales de pharmacodynamie et de therapie","studyType":"Clinical Study"},{"pmid":"13967100","year":"1963","title":"[Histological observations on the female tract after 6 months of treatment by methylestrenolone].","finding":"","journal":"Bulletin de la Societe royale belge de gynecologie et d'obstetrique","studyType":"Clinical Study"}],"tags":[{"label":"methylestrenolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03DC31","category":"atc"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"matronal","offLabel":[],"synonyms":["methylestrenolone","normethandrone","matronal","metalutin","methalutin","methylnortestosteron","normetandrone","normethandrolone","normethanedrolone","normethisterone","methylnortestosterone"],"timeline":[],"approvals":[],"brandName":"Matronal","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"methylestrenolone","explanation":"Imagine your body has locks on the cells that control muscle growth and development. Matronal is a key that fits into these locks, allowing the cells to receive signals that promote muscle growth and strength. This can be beneficial for people who need to build muscle mass, but it can also have negative effects if not used carefully.","oneSentence":"Matronal works by binding to and activating the androgen receptor, mimicking the effects of male sex hormones.","technicalDetail":"Methylestrenolone exerts its effects by binding to the androgen receptor (AR), a nuclear receptor that regulates gene expression in response to androgens such as testosterone and dihydrotestosterone (DHT). This binding event triggers a conformational change in the AR, allowing it to translocate to the nucleus and regulate the expression of target genes involved in muscle growth and development."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Normethandrone","title":"Normethandrone","extract":"Normethandrone, also known as methylestrenolone or methylnortestosterone and sold under the brand name Metalutin among others, is a progestin and androgen/anabolic steroid (AAS) medication which is used in combination with an estrogen in the treatment of amenorrhea and menopausal symptoms in women. It is taken by mouth.","wiki_history":"==History==\nNormethandrone has been marketed for medical use since 1957. The combination of normethandrone and methylestradiol was introduced by at least 1966.","wiki_society_and_culture":"==Society and culture==\n\n===Generic names===\nNormethandrone has not been assigned an  or other formal name designations.\n\n===Availability===\nNormethandrone is marketed in Brazil, Indonesia, and Venezuela in combination with methylestradiol or estradiol valerate."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1970","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=methylestrenolone","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Normethandrone","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:23:36.754613","biosimilars":[],"competitors":[{"drugName":"norethisterone","drugSlug":"norethisterone","fdaApproval":"1962-05-21","relationship":"same-class"},{"drugName":"etynodiol","drugSlug":"etynodiol","fdaApproval":"1966-03-23","relationship":"same-class"}],"genericName":"methylestrenolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"norethisterone","brandName":"norethisterone","genericName":"norethisterone","approvalYear":"1962","relationship":"same-class"},{"drugId":"etynodiol","brandName":"etynodiol","genericName":"etynodiol","approvalYear":"1966","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"743F1Z557A","CHEBI":"CHEBI:34896","UMLSCUI":"C0650248","ChEMBL_ID":"CHEMBL2106801","DRUGBANK_ID":"DB13533","PUBCHEM_CID":"5284597","SNOMEDCT_US":"725690007","MESH_SUPPLEMENTAL_RECORD_UI":"C073330"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":23,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03DC31","allCodes":["G03DC31","G03FA05"]},"biosimilarFilings":[],"recentPublications":[{"date":"1983 Mar","pmid":"6220143","title":"Inhibin production by bovine ovarian tissues in vitro and its regulation by androgens.","journal":"Journal of reproduction and fertility"},{"date":"1977","pmid":"144510","title":"Short-term and prolonged treatment with oral contraceptives and liver function.","journal":"Arzneimittel-Forschung"},{"date":"1968 Jul-Aug","pmid":"4237574","title":"[Synthesis of current knowledge of an inhibitor of libido in the male, the methylestrenolone].","journal":"L'Encephale"},{"date":"1967 Aug","pmid":"4227801","title":"[Action of methylestrenolone on the exploratory behavior of the male rat].","journal":"Archives internationales de pharmacodynamie et de therapie"},{"date":"1963","pmid":"13967100","title":"[Histological observations on the female tract after 6 months of treatment by methylestrenolone].","journal":"Bulletin de la Societe royale belge de gynecologie et d'obstetrique"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Matronal is a small molecule medication used in combination with an estrogen to treat amenorrhea and menopausal symptoms in women. It is taken by mouth and is a progestin and androgen/anabolic steroid medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}