{"id":"methylene-blue-mmx","safety":{"commonSideEffects":[{"rate":null,"effect":"Blue discoloration of urine and skin"},{"rate":null,"effect":"Gastrointestinal disturbances"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL550495","moleculeType":"Small molecule","molecularWeight":"373.91"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Methylene blue is a redox-active compound that crosses the blood-brain barrier and enhances mitochondrial electron transport chain function, reducing oxidative stress and neuroinflammation. The MMX (multi-matrix extended-release) formulation provides sustained delivery to optimize bioavailability and therapeutic effect in the central nervous system.","oneSentence":"Methylene Blue MMX is a modified-release formulation of methylene blue that acts as a mitochondrial function enhancer and antioxidant to improve cognitive and neurological outcomes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:49:54.508Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Mild cognitive impairment"},{"name":"Alzheimer's disease"}]},"trialDetails":[{"nctId":"NCT03287219","phase":"PHASE2","title":"Colon Staining Efficacy of Single Oral Doses of Methylene Blue MMX","status":"COMPLETED","sponsor":"Cosmo Technologies Ltd","startDate":"2011-05-02","conditions":"Colon Staining in Preparation for Colonoscopy","enrollment":114},{"nctId":"NCT01694966","phase":"PHASE3","title":"The Safety and Efficacy of Methylene Blue MMX® Modified Release Tablets Administered to Subjects Undergoing Screening or Surveillance Colonoscopy","status":"COMPLETED","sponsor":"Cosmo Technologies Ltd","startDate":"2013-09","conditions":"Colorectal Cancer","enrollment":1249}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Investigational Product: Methylene Blue MMX® modified release tablets","Active Ingredient: Methylene Blue"],"phase":"phase_3","status":"active","brandName":"Methylene Blue MMX®","genericName":"Methylene Blue MMX®","companyName":"Cosmo Technologies Ltd","companyId":"cosmo-technologies-ltd","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylene Blue MMX is a modified-release formulation of methylene blue that acts as a mitochondrial function enhancer and antioxidant to improve cognitive and neurological outcomes. Used for Mild cognitive impairment, Alzheimer's disease.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}