{"id":"methylcantharidimide-tablets","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal toxicity"},{"rate":null,"effect":"Hematologic effects"},{"rate":null,"effect":"Hepatotoxicity"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Cantharidin and its derivatives are known to inhibit serine/threonine protein phosphatase 2A (PP2A), which disrupts cellular signaling pathways critical for cancer cell survival and proliferation. By blocking PP2A activity, methylcantharidimide promotes apoptosis in cancer cells and may enhance immune responses. The drug has been used in traditional Chinese medicine and has demonstrated activity in various cancer models.","oneSentence":"Methylcantharidimide is a cantharidin derivative that induces apoptosis and inhibits protein phosphatase 2A (PP2A), leading to anti-tumor effects.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:54:47.764Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Various cancers (specific indications not well-documented in Western literature)"}]},"trialDetails":[{"nctId":"NCT03996681","phase":"PHASE4","title":"TACE Combined With Methylcantharidimide Tablets in the Treatment of Large and Unresectable Hepatocellular Carcinoma","status":"UNKNOWN","sponsor":"Suzhou Municipal Hospital","startDate":"2019-07-20","conditions":"Hepatocellular Carcinoma","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["GANYU"],"phase":"marketed","status":"active","brandName":"methylcantharidimide tablets","genericName":"methylcantharidimide tablets","companyName":"Suzhou Municipal Hospital","companyId":"suzhou-municipal-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylcantharidimide is a cantharidin derivative that induces apoptosis and inhibits protein phosphatase 2A (PP2A), leading to anti-tumor effects. Used for Various cancers (specific indications not well-documented in Western literature).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}