{"id":"methylatropine","rwe":[],"tags":[{"label":"methylatropine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"A03BB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Parasympatholytics","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methylatropinium","offLabel":[],"synonyms":["methylatropine","methylatropinium","atropine methonitrate","atropine methobromide","methylatropine nitrate"],"timeline":[],"aiSummary":"Methylatropinium is a small molecule with the synonyms 8-METHYLATROPINIUM NITRATE, ATROPINE METHONITRATE, and others.","approvals":[],"brandName":"Methylatropinium","ecosystem":[],"mechanism":{"target":"Muscarinic acetylcholine receptor DM1, Muscarinic acetylcholine receptor M1, Muscarinic acetylcholine receptor M2","modality":"Small Molecule","drugClass":"methylatropine","explanation":"Think of acetylcholine like a messenger that helps different parts of the body communicate with each other. When methylatropinium blocks this messenger, it can affect various bodily functions, such as muscle contractions, heart rate, and digestion. This can be useful in treating certain conditions, but it also means that the drug can have significant side effects if not used carefully.","oneSentence":"Methylatropinium works by blocking the action of acetylcholine, a neurotransmitter that helps transmit signals in the nervous system.","technicalDetail":"Methylatropinium is a competitive antagonist of the muscarinic acetylcholine receptor, specifically targeting the M1, M2, and M3 subtypes. By binding to these receptors, it reduces the effects of acetylcholine, leading to decreased parasympathetic tone and increased sympathetic tone."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4660","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYLATROPINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:39:10.844917","biosimilars":[],"competitors":[{"drugName":"methscopolamine","drugSlug":"methscopolamine","fdaApproval":"1953-04-09","genericCount":5,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"methylhomatropine","drugSlug":"methylhomatropine","fdaApproval":"1943-03-23","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"methylatropine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"methscopolamine","brandName":"methscopolamine","genericName":"methscopolamine","approvalYear":"1953","relationship":"same-class"},{"drugId":"methylhomatropine","brandName":"methylhomatropine","genericName":"methylhomatropine","approvalYear":"1943","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"001716","UNII":"80719I460H","CHEBI":"CHEBI:134749","VANDF":"4018467","INN_ID":"436","UMLSCUI":"C0066332","ChEMBL_ID":"CHEMBL1179176","KEGG_DRUG":"D01077","DRUGBANK_ID":"DB13833","PUBCHEM_CID":"5861","SNOMEDCT_US":"391795000","SECONDARY_CAS_RN":"52-88-0","MESH_SUPPLEMENTAL_RECORD_UI":"C006649"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":455,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"A03BB02","allCodes":["A03BB02"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}