{"id":"methyl-salicylate","rwe":[{"pmid":"41897735","year":"2026","title":"Dynamic Evolution of Aroma Characteristics in Ripened Pu-Erh Tea During Industrial Fermentation: Insights from GC-MS and Flavor Wheel Analysis.","finding":"","journal":"Foods (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41881319","year":"2026","title":"Research progress on chemical constituents and pharmacological activities of six Ericaceae species in Yi ethnic medicine.","finding":"","journal":"Journal of ethnopharmacology","studyType":"Clinical Study"},{"pmid":"41843041","year":"2026","title":"Influence of Conspecific Male Odour and Host Kairomones on the Behaviour of Sternochetus mangiferae, a Pest of Mangoes in Brazil and Ghana.","finding":"","journal":"Journal of chemical ecology","studyType":"Clinical Study"},{"pmid":"41820610","year":"2026","title":"Bodyguard Interactions: A Beneficial Endophyte Triggers Emission of Methyl Salicylate in Infested Tomato Plant Mediating Attraction of a Parasitoid Wasp.","finding":"","journal":"Journal of chemical ecology","studyType":"Clinical Study"},{"pmid":"41810421","year":"2026","title":"Revealing the influence of top-brewing and bottom-brewing methods on the flavor of green tea based on the interaction between EGCG and aroma compounds.","finding":"","journal":"Current research in food science","studyType":"Clinical Study"}],"_fda":{"id":"29791c3e-3ae3-2db5-e063-6394a90a2075","set_id":"0056b952-9870-485a-9f35-f985472875a9","openfda":{"unii":["L7T10EIP3A","LAV5U5022Y"],"route":["TOPICAL"],"rxcui":["282812"],"spl_id":["29791c3e-3ae3-2db5-e063-6394a90a2075"],"brand_name":["Mentholatum Pain Relieving"],"spl_set_id":["0056b952-9870-485a-9f35-f985472875a9"],"package_ndc":["10742-8169-1","10742-8169-2"],"product_ndc":["10742-8169"],"generic_name":["MENTHOL, METHYL SALICYLATE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["MENTHOL, UNSPECIFIED FORM","METHYL SALICYLATE"],"manufacturer_name":["The Mentholatum Company"],"application_number":["M017"],"is_original_packager":[true]},"purpose":["Purpose Menthol - Topical analgesic Methyl salicylate - Topical analgesic"],"version":"3","stop_use":["Stop use and ask a doctor if condition worsens excessive irritation, burning or discomfort of the skin develops symptoms persist for more than 7 days or clear up and occur again within a few days"],"warnings":["Warnings For external use only When using this product use only as directed do not get into eyes or on mucous membranes do not apply to wounds or to damaged skin do not bandage tightly do not use with a heating pad, other heat sources, or right after a shower/bath do not use in combination with other external analgesic products Stop use and ask a doctor if condition worsens excessive irritation, burning or discomfort of the skin develops symptoms persist for more than 7 days or clear up and occur again within a few days"],"when_using":["When using this product use only as directed do not get into eyes or on mucous membranes do not apply to wounds or to damaged skin do not bandage tightly do not use with a heating pad, other heat sources, or right after a shower/bath do not use in combination with other external analgesic products"],"effective_time":"20241217","active_ingredient":["Active ingredients Menthol 6% Methyl salicylate 20%"],"inactive_ingredient":["Inactive ingredients carbomer, lanolin oil, polysorbate 60, purified water, sorbitan monosterate, trolamine"],"indications_and_usage":["Uses temporarily relieves minor aches and pains of muscles and joints due to arthritis simple backache strains sprains"],"warnings_and_cautions":["For external use only"],"dosage_and_administration":["Directions adults and children 12 years and over: apply to affected area not more than 3 to 4 times daily children under 12 years: ask a doctor"],"spl_product_data_elements":["Mentholatum Pain Relieving menthol, methyl salicylate CARBOXYPOLYMETHYLENE LANOLIN OIL MINERAL OIL POLYSORBATE 60 WATER SORBITAN MONOSTEARATE TROLAMINE MENTHOL, UNSPECIFIED FORM MENTHOL METHYL SALICYLATE SALICYLIC ACID"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding, ask a healthcare professional before use."],"keep_out_of_reach_of_children":["Keep Out of Reach of Children. If swallowed, get medical help or contact a Poison Control Center right away."],"package_label_principal_display_panel":["Package/Label Principal Display Panel Mentholatum Pain Relieving Lotion"]},"tags":[{"label":"methyl salicylate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Aerosol","category":"form"},{"label":"Cream","category":"form"},{"label":"Active","category":"status"},{"label":"Arthritic Pain","category":"indication"},{"label":"Backache","category":"indication"},{"label":"Sprains and Strains","category":"indication"},{"label":"Hisamitsu Pharm Co","category":"company"},{"label":"Approved 2000s","category":"decade"},{"label":"Antirheumatic Agents","category":"pharmacology"},{"label":"Fixatives","category":"pharmacology"}],"phase":"marketed","safety":{"boxedWarnings":[],"safetySignals":[{"date":"","signal":"DRUG INEFFECTIVE","source":"FDA FAERS","actionTaken":"350 reports"},{"date":"","signal":"PAIN","source":"FDA FAERS","actionTaken":"139 reports"},{"date":"","signal":"NO ADVERSE EVENT","source":"FDA FAERS","actionTaken":"122 reports"},{"date":"","signal":"APPLICATION SITE PAIN","source":"FDA FAERS","actionTaken":"121 reports"},{"date":"","signal":"NAUSEA","source":"FDA FAERS","actionTaken":"113 reports"},{"date":"","signal":"DIARRHOEA","source":"FDA FAERS","actionTaken":"108 reports"},{"date":"","signal":"PRURITUS","source":"FDA FAERS","actionTaken":"95 reports"},{"date":"","signal":"HEADACHE","source":"FDA FAERS","actionTaken":"89 reports"},{"date":"","signal":"FATIGUE","source":"FDA FAERS","actionTaken":"88 reports"},{"date":"","signal":"APPLICATION SITE BURN","source":"FDA FAERS","actionTaken":"86 reports"}],"drugInteractions":[{"url":"/drug/phenprocoumon","drug":"phenprocoumon","action":"Avoid combination","effect":"May interact with Phenprocoumon","source":"DrugCentral","drugSlug":"phenprocoumon"},{"url":"/drug/warfarin","drug":"warfarin","action":"Monitor closely","effect":"May interact with Warfarin","source":"DrugCentral","drugSlug":"warfarin"}],"commonSideEffects":[],"contraindications":["Anemia","Anemia due to enzyme deficiency","Bacterial septicemia","Blood coagulation disorder","Body fluid retention","Breastfeeding (mother)","Cardiovascular event risk","Conduction disorder of the heart","Decreased respiratory function","Denuded skin","Diabetes mellitus","Disease of liver","Disorder of cardiovascular system","Disorder of skin","Factor II deficiency","Gastritis","Gastroesophageal reflux disease","Gastrointestinal hemorrhage","Gastrointestinal ulcer","Heart block","Hemophilia","Hepatic failure","Kidney disease","Nasal polyp","Open wound"],"specialPopulations":{"Pregnancy":"If pregnant or breast-feeding, ask health professional before use.","Paediatric use":"Keep out of reach of children."}},"trials":[],"aliases":[],"company":"Hisamitsu Pharm Co","patents":[{"source":"FDA Orange Book via DrugCentral","expires":"2030-01-03","territory":"US","patentNumber":"8809615"},{"source":"FDA Orange Book via DrugCentral","expires":"2027-08-01","territory":"US","patentNumber":"9233184"}],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=METHYL SALICYLATE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:12:27.897014+00:00"},"patents":{"url":"","method":"deterministic","source":"FDA Orange Book","rawText":"","confidence":1,"sourceType":"fda_orange_book","retrievedAt":"2026-04-20T03:12:27.896577+00:00"},"timeline":{"url":"https://en.wikipedia.org/wiki/Methyl Salicylate","method":"deterministic","source":"Wikipedia","rawText":"","confidence":0.8,"sourceType":"wikipedia","retrievedAt":"2026-04-20T03:12:37.101629+00:00"},"aiSummary":{"url":"","method":"ai_extraction","source":"AI Strategic Summary","aiModel":"featherless","rawText":"","confidence":0.9,"sourceType":"ai_extraction","retrievedAt":"2026-04-20T03:12:45.613488+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:12:34.891170+00:00"},"regulatory.us":{"url":"","method":"api_direct","source":"FDA Drugs@FDA","rawText":"","confidence":1,"sourceType":"fda_drugsfda","retrievedAt":"2026-04-20T03:12:26.477599+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYL SALICYLATE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:12:35.969521+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:12:25.307869+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:12:25.307932+00:00"},"safety.safetySignals":{"url":"https://api.fda.gov/drug/event.json","method":"api_direct","source":"FDA FAERS","rawText":"","confidence":1,"sourceType":"fda_faers","retrievedAt":"2026-04-20T03:12:38.137155+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL108545/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:12:36.988421+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"M017","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:12:25.307944+00:00"}},"allNames":"salonpas","offLabel":[],"synonyms":["methyl salicylate","analgit","methyl 2-hydroxybenzoate","methyl ester 2-hydroxy benzoic acid"],"timeline":[{"date":"2008-02-20","type":"positive","source":"DrugCentral","milestone":"FDA approval (Hisamitsu Pharm Co)"}],"aiSummary":"Methyl Salicylate, marketed as Salonpas by Hisamitsu Pharmaceutical Co., is a topical analgesic primarily indicated for arthritic pain relief and holds a significant market presence. Its key strength lies in the mechanism of action, where methyl salicylate is absorbed through the skin to block pain signals to the brain, providing targeted relief. The primary risk is the key composition patent expiry in 2028, which could lead to increased competition from generic products.","approvals":[{"date":"2008-02-20","orphan":false,"company":"HISAMITSU PHARM CO","regulator":"FDA"}],"brandName":"Salonpas","ecosystem":[{"indication":"Arthritic Pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"camphor","slug":"camphor","company":""},{"name":"capsaicin","slug":"capsaicin","company":"Acorda"},{"name":"levomenthol","slug":"levomenthol","company":""}],"globalPrevalence":null},{"indication":"Backache","otherDrugs":[{"name":"aceclofenac","slug":"aceclofenac","company":""},{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"camphor","slug":"camphor","company":""}],"globalPrevalence":null},{"indication":"Sprains and Strains","otherDrugs":[{"name":"camphor","slug":"camphor","company":""},{"name":"capsaicin","slug":"capsaicin","company":"Acorda"},{"name":"diclofenac","slug":"diclofenac","company":""},{"name":"levomenthol","slug":"levomenthol","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"methyl salicylate","explanation":"","oneSentence":"","technicalDetail":"Methyl salicylate, the active ingredient in Salonpas, acts as a nonsteroidal anti-inflammatory drug (NSAID) by inhibiting the enzyme cyclooxygenase (COX), which is responsible for the production of prostaglandins. This inhibition leads to a decrease in prostaglandin levels, resulting in reduced pain and inflammation."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Transdermal_analgesic_patch","title":"Transdermal analgesic patch","extract":"A transdermal analgesic or pain relief patch is a medicated adhesive patch used to relieve minor to severe pain. There are many types of analgesic patches based on the main ingredients in the patches. These include patches containing counterirritants, which are used to treat mild to moderate pain, and patches containing opioids such as buprenorphine and fentanyl, used to relieve moderate to severe pain. Fentanyl is often used for opioid-tolerant patients. Nitroglycerin, also known as glyceryl trinitrate (GTN), a medication used for heart failure, high blood pressure, anal fissures, painful periods, and to treat and prevent chest pain, can also be found in patches. Beyond these are patches that contain drugs such as diclofenac and lidocaine and various other drugs. The main purpose of transdermal analgesic patches are to administer drugs in a more viable way to patients, as opposed to oral consumption or intravenous administration such as an injection.","wiki_history":"== History ==\nTransdermal drug delivery was influenced by topical drug delivery. Sherman Kramer and Dale Wurster, his teacher, were both based in pharmacology and are credited with the beginning stages of transdermal patch delivery in 1961. By attaching a diffusion cell to the volunteers and monitoring their levels of the drug administered, it was discovered that the levels of the drug could be affected by the absorption of the skin and the diffusion area of the patch. 10 years later, Alejandro Zaffaroni filed a patent for transdermal drug delivery through a rate-controlling membrane. Arnold Beckett, a British pharmacist, held experiments with a patch system that were studied and proven to maintain steady blood levels through administration of the drug. These discoveries laid the foundation for transdermal patch systems and individual research with specific drugs for transdermal patch systems followed."},"commercial":{"launchDate":"2008","_launchSource":"DrugCentral (FDA 2008-02-20, HISAMITSU PHARM CO)"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4245","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=METHYL%20SALICYLATE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHYL 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