{"id":"methyl-prednisolonate","safety":{"commonSideEffects":[{"rate":null,"effect":"Hyperglycemia"},{"rate":null,"effect":"Hypertension"},{"rate":null,"effect":"Osteoporosis (with chronic use)"},{"rate":null,"effect":"Immunosuppression and increased infection risk"},{"rate":null,"effect":"Insomnia and mood changes"},{"rate":null,"effect":"Gastrointestinal upset"}]},"_chembl":{"chemblId":"CHEMBL1201014","moleculeType":"Small molecule","molecularWeight":"484.39"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methylprednisolone acts as a glucocorticoid receptor agonist, translocating to the nucleus to modulate gene expression of inflammatory mediators. It reduces the production of cytokines, chemokines, and adhesion molecules, thereby decreasing immune cell activation and migration to sites of inflammation. This broad immunosuppressive and anti-inflammatory action makes it effective across multiple inflammatory and autoimmune conditions.","oneSentence":"Methylprednisolone is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:42.456Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis)"},{"name":"Allergic reactions and asthma exacerbations"},{"name":"Adrenocortical insufficiency"},{"name":"Cerebral edema and spinal cord injury"}]},"trialDetails":[{"nctId":"NCT06209606","phase":"EARLY_PHASE1","title":"Pilot Study Using Changes in Serum BCMA to Determine Disease Progression in Multiple Myeloma","status":"RECRUITING","sponsor":"Oncotherapeutics","startDate":"2022-12-08","conditions":"Multiple Myeloma","enrollment":30},{"nctId":"NCT03110822","phase":"PHASE1","title":"A Phase 1 Study of Ruxolitinib, Steroids and Lenalidomide for Relapsed/Refractory Multiple Myeloma (RRMM) Patients","status":"RECRUITING","sponsor":"Oncotherapeutics","startDate":"2017-02-01","conditions":"Multiple Myeloma","enrollment":134},{"nctId":"NCT05103397","phase":"PHASE4","title":"High Dose Methylprednisolone Verses Low Dose in Correction of Congenital Acynotic Heart Disease","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2021-10-16","conditions":"Anesthesia","enrollment":75},{"nctId":"NCT04450030","phase":"","title":"Immunoadsorption Versus High-dose Intravenous Corticosteroids in Relapsing Multiple Sclerosis","status":"UNKNOWN","sponsor":"University Hospital Muenster","startDate":"2018-08-01","conditions":"Multiple Sclerosis, Relapsing-Remitting","enrollment":204},{"nctId":"NCT04467450","phase":"EARLY_PHASE1","title":"Ultrasound Guided Botulinum Toxin Type A Injection of Subacromial-Subdeltoid Bursa in Hemiplegic Shoulder Pain","status":"UNKNOWN","sponsor":"Benha University","startDate":"2020-06-01","conditions":"Subacromial Bursitis, Subdeltoid Bursitis","enrollment":36},{"nctId":"NCT04467892","phase":"PHASE2","title":"Low Versus High Corticosteroid Use in Ventilator Associated Pneumonia","status":"COMPLETED","sponsor":"King Abdul Aziz Specialist Hospital","startDate":"2018-01-02","conditions":"Ventilator Associated Pneumonia","enrollment":240},{"nctId":"NCT04402177","phase":"PHASE4","title":"This Study Aim is to Compare the Effect of Oral Methyl Prednisolone on Different Radiological Patterns of Hypersensitivity Pneumonitis as it Was Found That Not All Patients Get Satisfying Therapeutic Effect After Taking Corticosteroids.","status":"UNKNOWN","sponsor":"Al-Azhar University","startDate":"2020-07-01","conditions":"Hypersensitivity Pneumonitis","enrollment":110}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["steroid","Depomedrol 40mg /2ml"],"phase":"marketed","status":"active","brandName":"Methyl Prednisolonate","genericName":"Methyl Prednisolonate","companyName":"Ain Shams University","companyId":"ain-shams-university","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methylprednisolone is a synthetic corticosteroid that suppresses the immune system and reduces inflammation by binding to glucocorticoid receptors and inhibiting pro-inflammatory cytokine production. Used for Inflammatory and autoimmune disorders (rheumatoid arthritis, lupus, vasculitis), Allergic reactions and asthma exacerbations, Adrenocortical insufficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":5,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}