{"id":"methyl-nicotinate","rwe":[],"_fda":{"id":"3b01c59f-9f1a-ccbf-e063-6394a90a80ba","set_id":"39af3350-75a8-5f8c-e063-6394a90a6e96","openfda":{"upc":["0382944500106"],"unii":["S07O44R1ZM","L7T10EIP3A","7B1AVU9DJN","LAV5U5022Y"],"route":["TOPICAL"],"rxcui":["2640874"],"spl_id":["3b01c59f-9f1a-ccbf-e063-6394a90a80ba"],"brand_name":["Sync Quadra"],"spl_set_id":["39af3350-75a8-5f8c-e063-6394a90a6e96"],"package_ndc":["82944-500-10"],"product_ndc":["82944-500"],"generic_name":["METHYL SALICYLATE, MENTHOL, CAPSAICIN, METHYL NICOTINATE"],"product_type":["HUMAN OTC DRUG"],"substance_name":["CAPSAICIN","MENTHOL","METHYL NICOTINATE","METHYL SALICYLATE"],"manufacturer_name":["Ion Pharma, LLC"],"application_number":["505G(a)(3)"],"is_original_packager":[true]},"purpose":["Drug facts Drug facts Active ingredients (in each patch)...... Purpose Menthol 10% ............................................. Topical analgesic Methyl salicylate 10% .............................. Topical analgesic Capsaicin 0.025% ................................. Topical analgesic Methyl nicotinate 0.25% ............................. Topical analgesic"],"version":"2","stop_use":["Stop use section Stop use and ask a doctor if condition worsens symptoms last for more than 7 days or clear up and occur again within a few days you experience signs of stomach bleeding, such as feeling faint, vomiting blood, or have bloody or black stools redness or swelling occurs a burning sensation occurs"],"warnings":["NSAID warning, Do not use section For external use only Stomach bleeding warning: This product contains a NSAID, which may cause stomach bleeding. The chance is small but higher if you: are age 60 or older have had stomach ulcers or bleeding problems take a blood thinning (anticoagulant) or steroid drug take other drugs containing NSAID (aspirin, ibuprofen, naproxen, or others) have 3 or more alcoholic drinks every day while using this product Do not use: on the face or rashes on wounds or damaged skin if allergic to aspirin or other NSIADs with a heating pad when sweating (such as from exercise or heat) any patch from a pouch that has been open 14 days or more days right before or after heart surgery do not bandage tightly"],"questions":["Questions or comments section Questions or Comments: 833.711.8833 info@syncrelief.com"],"when_using":["When using this product When using this product wash hands after applying or removing patch. Avoid contact with eyes. If eye contact occurs, rinse thoroughly with water. The risk of heart attack or stroke may increase if you use more than directed or for longer than directed."],"effective_time":"20250728","inactive_ingredient":["Hypoallergenic acrylic adhesive"],"indications_and_usage":["Uses section Uses: Temporarily relieves minor aches and pains of muscles & joints associated with: Strains Sprains Simple Backache Arhtritis Bruises"],"dosage_and_administration":["Directions section Adults and children 10 years of age and older: only use one patch at a time clean and dry affected area remove patch from backing film and apply to skin (see illustration) apply 1 patch to the affected area or intact skin up to 36 hours do not use more than 2 patches per day do not use for more than 3 days in a row unless prescribed and instructed by a healthcare provider the used patch should be removed from the skin when a new one is applied"],"spl_product_data_elements":["Sync Quadra Methyl salicylate, Menthol, Capsaicin, Methyl nicotinate MENTHOL MENTHOL CAPSAICIN CAPSAICIN METHYL NICOTINATE NIACIN ACRYLIC ACID METHYL SALICYLATE SALICYLIC ACID"],"pregnancy_or_breast_feeding":["If pregnant or breast-feeding section Ask a doctor before use while breastfeeding and during the first 6 months of pregnancy. Do not use during the last 3 months of pregnancy because it may cause problems in the unborn child or complications during delivery."],"keep_out_of_reach_of_children":["Keep out of reach of children section If put in mouth, get medical help or contact a Poison Control Center right away. Package not child resistant. Dispose of the used patches after folding sticky ends together."],"package_label_principal_display_panel":["NDC: 82944-500-10 NEW 1st OF ITS KIND Quadra PAIN RELIEF PATCH METHYL SALICYLATE MENTHOL CAPSAICIN METHYL NICOTINATE WATER RESISTANT TECHNOLOGY Relief in Motion 4 POWERFUL INGREDIENTS METHYL NICOTINATE ADDS TO THE BODY'S NaMN AND NAD+ PRODUCTION * APPLY UP TO 36 HOURS MADE IN THE USA MATRIX TECHNOLOGY 10 FLEX PATCHES Quadra-Box"]},"tags":[{"label":"methyl nicotinate","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Topical","category":"route"},{"label":"Cream","category":"form"},{"label":"Lotion","category":"form"},{"label":"Patch","category":"form"},{"label":"Active","category":"status"},{"label":"Joint pain","category":"indication"}],"phase":"marketed","safety":{"boxedWarnings":[]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=methyl nicotinate","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:15:16.340704+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:15:22.241605+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=methyl nicotinate","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:15:22.569919+00:00"},"administration.route":{"url":"","method":"deterministic","source":"FDA Label","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:15:15.151991+00:00"},"safety.boxedWarnings":{"url":"","method":"deterministic","source":"FDA Label (no boxed warning)","rawText":"","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:15:15.152013+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL379845/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:15:23.604603+00:00"},"regulatory.fda_application":{"url":"","method":"deterministic","source":"FDA Label","rawText":"505G(a)(3)","confidence":1,"sourceType":"fda_label","retrievedAt":"2026-04-20T03:15:15.152017+00:00"}},"allNames":"methyl 3-pyridinecarboxylate","offLabel":[],"synonyms":["methyl nicotinate","methyl 3-pyridinecarboxylate"],"timeline":[],"aiSummary":"Methyl 3-Pyridinecarboxylate, also known as methyl nicotinate, is a small molecule drug in the methyl nicotinate class. It is used to treat joint pain. The commercial status of methyl nicotinate is not specified, but it is approved for use in certain indications. As a methyl nicotinate, it works by stimulating blood flow to the affected area, providing relief from pain and inflammation. However, more information is needed to fully understand its pharmacological properties and safety considerations.","approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Methyl 3-Pyridinecarboxylate","ecosystem":[{"indication":"Joint pain","otherDrugs":[{"name":"acetylsalicylic acid","slug":"acetylsalicylic-acid","company":"Endo Pharms"},{"name":"caffeine","slug":"caffeine","company":"Novartis"},{"name":"magnesium salicylate","slug":"magnesium-salicylate","company":""},{"name":"naproxen","slug":"naproxen","company":"Roche Palo"}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"methyl nicotinate","explanation":"","oneSentence":"","technicalDetail":"Methyl nicotinate acts as a vasodilator, increasing the diameter of blood vessels and improving blood flow through the affected area, which in turn reduces pain and inflammation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3355","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=methyl%20nicotinate","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=methyl nicotinate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:39:07.469154","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:15:25.835563+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[],"genericName":"methyl nicotinate","indications":{"approved":[{"name":"Joint pain","source":"DrugCentral","snomedId":57676002,"regulator":"FDA","eligibility":"No specific patient eligibility criteria mentioned"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT06599918","phase":"PHASE2","title":"Study of the Efficacy and Safety of Nicotinamide in Patients With Liver Fibrosis (NICOFIB)","status":"RECRUITING","sponsor":"Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau","startDate":"2024-04-23","conditions":["Fatty Liver","Obesity","Hepatic Fibrosis","NAFLD","Nicotinamide","Overweight and Obese Adults"],"enrollment":30,"completionDate":"2028-12"},{"nctId":"NCT06624137","phase":"","title":"Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics","status":"RECRUITING","sponsor":"Yale University","startDate":"2024-12-12","conditions":["OCD","Major Depressive Disorder (MDD)","Alcohol Use Disorder (AUD)","Healthy Volunteer","Migraine","PTSD","PTSD - 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Faculty of Applied Sciences","startDate":"2019-11-25","conditions":["Nail Damage"],"enrollment":34,"completionDate":"2020-09-01"},{"nctId":"NCT01324297","phase":"","title":"The Topical Niacin Skin Flush Test in First Episode Psychosis","status":"TERMINATED","sponsor":"Nova Scotia Health Authority","startDate":"2011-12","conditions":["Psychotic Disorders","Schizophrenia"],"enrollment":107,"completionDate":"2016-07"},{"nctId":"NCT02458924","phase":"PHASE2,PHASE3","title":"Niacin Skin Flush Response in Patients With Schizophrenia","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2014-01","conditions":["Schizophrenia"],"enrollment":100,"completionDate":"2014-09"},{"nctId":"NCT00773162","phase":"PHASE3","title":"Flushing in Social Anxiety Disorder on Seroquel","status":"COMPLETED","sponsor":"START Clinic for Mood and Anxiety Disorders","startDate":"2008-10","conditions":["Social Anxiety Disorder"],"enrollment":21,"completionDate":"2013-08"},{"nctId":"NCT00485888","phase":"PHASE2","title":"Flushing in Social Anxiety Disorder on Cipralex","status":"COMPLETED","sponsor":"START Clinic for Mood and Anxiety Disorders","startDate":"2008-10","conditions":["Social Anxiety Disorder"],"enrollment":71,"completionDate":"2013-08"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"route":"Topical","formulation":"Cream, Lotion, Patch","formulations":[{"form":"CREAM","route":"TOPICAL","productName":"Arth Arrest"},{"form":"LOTION","route":"TOPICAL","productName":"Arth RX Topical Analgesic"},{"form":"PATCH","route":"TOPICAL","productName":"Nuvira"}]},"crossReferences":{"NUI":"N0000179190","MMSL":"2275","NDDF":"001052","UNII":"7B1AVU9DJN","VUID":"4020266","CHEBI":"CHEBI:134761","VANDF":"4017661","RXNORM":"29900","UMLSCUI":"C0066412","chemblId":"CHEMBL379845","ChEMBL_ID":"CHEMBL379845","KEGG_DRUG":"D04991","DRUGBANK_ID":"DB13882","PDB_CHEM_ID":" NIO","PUBCHEM_CID":"7151","SNOMEDCT_US":"273943001","MESH_SUPPLEMENTAL_RECORD_UI":"C008473"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":181,"therapeuticAreas":["Pain"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T03:15:25.835563+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}