{"id":"methoxyphenamine","rwe":[{"pmid":"41022593","year":"2025","title":"[Sangma Zhike Formula alleviates airway inflammation and hyperresponsiveness in rats with postinfectious cough by inhibiting the TRPV1-SP/CGRP and pyroptosis pathways].","finding":"","journal":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University","studyType":"Clinical Study"},{"pmid":"40641875","year":"2025","title":"Altered upper respiratory tract microbiota in laryngeal cough attributed to lung yin deficiency and the modulatory effects of Yangyin Qingfei Oral Liquid.","finding":"","journal":"Frontiers in microbiology","studyType":"Clinical Study"},{"pmid":"40311897","year":"2025","title":"Occurrence and removal of pharmaceuticals in hospital wastewater and the contribution to wastewater treatment plants.","finding":"","journal":"Environmental research","studyType":"Clinical Study"},{"pmid":"40151828","year":"2025","title":"Combinations of compound cold medicines should be used with caution: a case series.","finding":"","journal":"Frontiers in medicine","studyType":"Clinical Study"},{"pmid":"39677958","year":"2024","title":"Characterization and clinical outcomes of outpatients with subacute or chronic post COVID-19 cough: a real-world study.","finding":"","journal":"PeerJ","studyType":"Clinical Study"}],"tags":[{"label":"methoxyphenamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"R03CB02","category":"atc"},{"label":"Active","category":"status"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic beta-Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"ortoxine","offLabel":[],"synonyms":["methoxyphenamine","methoxiphenadrin","2-Methoxymethamphetamine","methoxyphenadrine","methoxyphenamin","orthoxine","ortodrinex","ortoxine","methoxyphenamine hydrochloride","methoxyphenamine HCl"],"timeline":[],"approvals":[],"brandName":"Ortoxine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"methoxyphenamine","explanation":"Imagine Ortoxine as a key that unlocks a specific lock in the body, allowing it to work properly. However, the exact lock and how it works are still not fully understood. More research is needed to determine the precise mechanism of action.","oneSentence":"Ortoxine works by interacting with specific biological targets to produce a therapeutic effect.","technicalDetail":"Ortoxine's mechanism of action is thought to involve the inhibition of certain enzymes or receptors, although the specific molecular details are currently unknown."},"commercial":{"revenueYear":2025,"annualRevenue":172,"revenueSource":"Teva 2026-02-03 (verified from SEC filing)","revenueCurrency":"USD","revenueConfidence":"high"},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1755","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=METHOXYPHENAMINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHOXYPHENAMINE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:38:53.604305","biosimilars":[],"competitors":[{"drugName":"isoprenaline","drugSlug":"isoprenaline","fdaApproval":"1956-03-09","relationship":"same-class"},{"drugName":"orciprenaline","drugSlug":"orciprenaline","fdaApproval":"1973-07-31","relationship":"same-class"}],"genericName":"methoxyphenamine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"isoprenaline","brandName":"isoprenaline","genericName":"isoprenaline","approvalYear":"1956","relationship":"same-class"},{"drugId":"orciprenaline","brandName":"orciprenaline","genericName":"orciprenaline","approvalYear":"1973","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT07103980","phase":"PHASE1,PHASE2","title":"Inhaled Mesenchymal Stem Cell-Derived Exosomes in the Treatment of Post-Infectious Cough: A Single-Center Randomized Controlled Clinical Trial","status":"RECRUITING","sponsor":"Shanghai Changzheng Hospital","startDate":"2024-07-16","conditions":["Post-Infectious Cough"],"enrollment":40,"completionDate":"2025-12-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001799","UNII":"J3Z5SRI26Z","CHEBI":"CHEBI:134817","INN_ID":"137","RXNORM":"29704","UMLSCUI":"C0066165","ChEMBL_ID":"CHEMBL2010507","KEGG_DRUG":"D01635","DRUGBANK_ID":"DB13624","PUBCHEM_CID":"4117","SNOMEDCT_US":"69351002","SECONDARY_CAS_RN":"5588-10-3","MESH_SUPPLEMENTAL_RECORD_UI":"C005157"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":93,"therapeuticAreas":["Other"],"_revenueScrapedAt":"2026-03-31 14:09:35.487336+00","atcClassification":{"source":"DrugCentral","atcCode":"R03CB02","allCodes":["R03CB02"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sept 20","pmid":"41022593","title":"[Sangma Zhike Formula alleviates airway inflammation and hyperresponsiveness in rats with postinfectious cough by inhibiting the TRPV1-SP/CGRP and pyroptosis pathways].","journal":"Nan fang yi ke da xue xue bao = Journal of Southern Medical University"},{"date":"2025","pmid":"40641875","title":"Altered upper respiratory tract microbiota in laryngeal cough attributed to lung yin deficiency and the modulatory effects of Yangyin Qingfei Oral Liquid.","journal":"Frontiers in microbiology"},{"date":"2025 Aug 15","pmid":"40311897","title":"Occurrence and removal of pharmaceuticals in hospital wastewater and the contribution to wastewater treatment plants.","journal":"Environmental research"},{"date":"2025","pmid":"40151828","title":"Combinations of compound cold medicines should be used with caution: a case series.","journal":"Frontiers in medicine"},{"date":"2024","pmid":"39677958","title":"Characterization and clinical outcomes of outpatients with subacute or chronic post COVID-19 cough: a real-world study.","journal":"PeerJ"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Ortoxine is a small molecule with the synonyms METHOXYPHENAMINE, METHOXYPHENAMINE, and METOXIFENAMINA.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}