{"id":"methoxyflurane-meof","safety":{"commonSideEffects":[{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Nephrotoxicity (at high/prolonged exposure)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methoxyflurane acts as a general anesthetic by enhancing inhibitory GABAergic neurotransmission and inhibiting excitatory glutamatergic signaling in the central nervous system. It was historically used for general anesthesia and analgesia but has been largely withdrawn from many markets due to nephrotoxicity concerns. In recent years, it has been reintroduced in some regions at sub-anesthetic doses for acute pain relief and anxiety.","oneSentence":"Methoxyflurane is a volatile halogenated ether anesthetic that depresses the central nervous system to produce anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:28.660Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain relief (trauma, musculoskeletal injury)"},{"name":"Anxiety relief in acute settings"}]},"trialDetails":[{"nctId":"NCT03868436","phase":"PHASE4","title":"PENTHROX™ in the Canadian Emergency Department (ED)","status":"COMPLETED","sponsor":"Purdue Pharma, Canada","startDate":"2019-04-08","conditions":"Pain, Acute","enrollment":99},{"nctId":"NCT04412642","phase":"PHASE4","title":"Low Dose Methoxyflurane for Pain Relief During Minor Out-patient Urologic Procedures","status":"UNKNOWN","sponsor":"Sunnybrook Health Sciences Centre","startDate":"2020-05-31","conditions":"Pain, Acute","enrollment":10}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Penthrox"],"phase":"marketed","status":"active","brandName":"Methoxyflurane, MEOF","genericName":"Methoxyflurane, MEOF","companyName":"Sunnybrook Health Sciences Centre","companyId":"sunnybrook-health-sciences-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methoxyflurane is a volatile halogenated ether anesthetic that depresses the central nervous system to produce anesthesia and analgesia. Used for Acute pain relief (trauma, musculoskeletal injury), Anxiety relief in acute settings.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}