{"id":"methoxyflurane-m","safety":{"commonSideEffects":[{"rate":null,"effect":"Nephrotoxicity (at higher doses)"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Dizziness"},{"rate":null,"effect":"Nausea and vomiting"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL1341","moleculeType":"Small molecule","molecularWeight":"164.97"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methoxyflurane acts as a general anesthetic by enhancing inhibitory GABAergic neurotransmission and inhibiting excitatory glutamatergic signaling in the central nervous system. It was historically used for general anesthesia and analgesia but has been largely withdrawn from many markets due to nephrotoxicity concerns associated with its metabolites. In recent years, it has been reintroduced in some regions (including Europe) at sub-anesthetic doses for acute pain relief and anxiety.","oneSentence":"Methoxyflurane is a volatile halogenated ether anesthetic that depresses the central nervous system to produce anesthesia and analgesia.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:34:25.142Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute pain relief and anxiety (sub-anesthetic doses)"},{"name":"General anesthesia (historical use, largely discontinued)"}]},"trialDetails":[{"nctId":"NCT03894800","phase":"PHASE4","title":"Determination of Analgesic Equipotent Doses of Inhaled Metoxyflurane vs. Intravenous Fentanyl","status":"COMPLETED","sponsor":"Oslo University Hospital","startDate":"2019-04-23","conditions":"Acute Pain, Trauma, Hypovolemia","enrollment":12}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":28,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["NaCl"],"phase":"marketed","status":"active","brandName":"Methoxyflurane (M)","genericName":"Methoxyflurane (M)","companyName":"Oslo University Hospital","companyId":"oslo-university-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methoxyflurane is a volatile halogenated ether anesthetic that depresses the central nervous system to produce anesthesia and analgesia. Used for Acute pain relief and anxiety (sub-anesthetic doses), General anesthesia (historical use, largely discontinued).","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}