{"id":"methoxsalen-ecp","safety":{"commonSideEffects":[{"rate":null,"effect":"Photosensitivity"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Headache"}]},"_chembl":{"chemblId":"CHEMBL416","moleculeType":"Small molecule","molecularWeight":"216.19"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methoxsalen is a psoralen that becomes activated when exposed to UVA light, generating reactive oxygen species that damage DNA and trigger cell death. In ECP, patient blood is treated extracorporeally with methoxsalen and UVA exposure, then reinfused, allowing selective destruction of pathogenic T cells while modulating immune responses. This combination is used primarily in cutaneous T-cell lymphomas where circulating malignant cells can be targeted.","oneSentence":"Methoxsalen combined with extracorporeal photochemotherapy (ECP) uses a photosensitizing agent activated by ultraviolet A light to induce apoptosis in circulating malignant T cells.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:40.358Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Cutaneous T-cell lymphoma (mycosis fungoides)"},{"name":"Sézary syndrome"}]},"trialDetails":[{"nctId":"NCT04870437","phase":"NA","title":"Impact of ExtraCorporeal Phototherapy (ECP) on Auxiliary Follicular T-lymphocytes and Circulating B-lymphocytes During Chronic AntiBody-Mediated Rejection in Kidney Transplantation.","status":"RECRUITING","sponsor":"University Hospital, Angers","startDate":"2022-04-27","conditions":"Kidney Transplantation","enrollment":30},{"nctId":"NCT05157581","phase":"","title":"Extracorporeal Photopheresis in Sezary Syndrome","status":"RECRUITING","sponsor":"Oleg E. 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of the Procedure and of the Cell Product","status":"COMPLETED","sponsor":"Fondazione Policlinico Universitario Agostino Gemelli IRCCS","startDate":"2022-05-26","conditions":"Graft Vs Host Disease, Extracorporeal Photopheresis","enrollment":27},{"nctId":"NCT02181257","phase":"PHASE3","title":"Extracorporeal Photopheresis for Medicare Recipients of Lung Allografts","status":"ACTIVE_NOT_RECRUITING","sponsor":"Washington University School of Medicine","startDate":"2015-01","conditions":"Bronchiolitis Obliterans Syndrome (BOS)","enrollment":280},{"nctId":"NCT04291261","phase":"PHASE2","title":"Extracorporal Photopheresis With UVADEX Plus Standard Steroid Treatment for High Risk Acute Graft-versus-host Disease","status":"ACTIVE_NOT_RECRUITING","sponsor":"Universitätsklinikum Hamburg-Eppendorf","startDate":"2020-05-18","conditions":"Acute-graft-versus-host Disease","enrollment":24},{"nctId":"NCT04986605","phase":"PHASE2","title":"Extracorporeal Photopheresis in Early Diffuse Cutaneous Systemic Sclerosis","status":"NOT_YET_RECRUITING","sponsor":"London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's","startDate":"2025-07-01","conditions":"Diffuse Cutaneous Systemic Sclerosis","enrollment":15},{"nctId":"NCT00179855","phase":"PHASE2, PHASE3","title":"Extracorporeal Photopheresis for Acute Graft Versus Host Disease","status":"COMPLETED","sponsor":"Ann & Robert H Lurie Children's Hospital of Chicago","startDate":"2003-07","conditions":"Graft Versus Host Disease, Cancer, Stem Cell Transplantation","enrollment":10},{"nctId":"NCT05721079","phase":"NA","title":"Extracorporeal Photopheresis (ECP) After Lung Transplantation","status":"COMPLETED","sponsor":"Medical University of Vienna","startDate":"2017-03-01","conditions":"Lung Transplant Infection, Lung Transplant Rejection","enrollment":62},{"nctId":"NCT05882331","phase":"NA","title":"Extracorporeal Photopheresis as a Possible Therapeutic Approach to Adults With Severe and Critical 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Hospital","startDate":"2017-09-20","conditions":"Cutaneous T-Cell Lymphoma, Unspecified, Chronic Graft Versus Host Disease in Skin","enrollment":7},{"nctId":"NCT04792294","phase":"","title":"Multicenter Analysis of Efficacy and Outcomes of Extracorporeal Photopheresis as Treatment of Chronic Lung Allograft Dysfunction","status":"UNKNOWN","sponsor":"Medical University of Vienna","startDate":"2005-01-01","conditions":"Lung Transplant Rejection","enrollment":800},{"nctId":"NCT02524847","phase":"PHASE3","title":"Methoxsalen and Extracorporeal Photopheresis (ECP) for the Treatment of Pediatric Participants With Steroid Refractory Acute Graft Versus Host Disease","status":"TERMINATED","sponsor":"Therakos, Inc., a Mallinckrodt Company","startDate":"2016-01-20","conditions":"Steroid Refractory Acute Graft Versus Host Disease","enrollment":29},{"nctId":"NCT02322190","phase":"PHASE2","title":"Biomarkers in Acute Graft-Versus-Host Disease and Extracorporeal Photopheresis Added to Investigator Chosen Therapies of Steroid Refractory Acute GVHD","status":"TERMINATED","sponsor":"National Cancer Institute (NCI)","startDate":"2014-12-20","conditions":"Chronic Graft vs. Host Disease, Graft vs Host Disease, Graft-Versus-Host Disease","enrollment":5},{"nctId":"NCT01380535","phase":"EARLY_PHASE1","title":"Extracorporeal Photopheresis (ECP) With Methoxsalen for Chronic Graft Versus Host Disease (cGVHD)","status":"COMPLETED","sponsor":"Mallinckrodt","startDate":"2011-11","conditions":"Chronic Graft Versus Host Disease","enrollment":60},{"nctId":"NCT02296346","phase":"NA","title":"Open-Label Study to Evaluate the Efficacy of ECP in Secondary Progressive Multiple Sclerosis","status":"TERMINATED","sponsor":"University of Utah","startDate":"2014-10","conditions":"Secondary Progressive Multiple Sclerosis","enrollment":13},{"nctId":"NCT00221039","phase":"PHASE4","title":"Photopheresis as an Interventional Therapy for the Treatment of CTCL (Cutaneous T-Cell Lymphoma, Mycosis Fungoides) Stage 1A, 1B, 2A","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2004-04-02","conditions":"Cutaneous T Cell Lymphoma, Mycosis Fungoides","enrollment":7},{"nctId":"NCT03605940","phase":"PHASE2","title":"A Study Comparing Corticosteroids Alone Versus Corticosteroids and Extracorporal Photopheresis (ECP) as First-line Treatment of Standard II Acute Graft-versus-host Disease","status":"UNKNOWN","sponsor":"Central Hospital, Nancy, France","startDate":"2018-10-01","conditions":"Acute-graft-versus-host Disease","enrollment":78},{"nctId":"NCT00282503","phase":"PHASE3","title":"Extracorporeal Photoimmune Therapy With UVADEX for the Treatment of Acute Graft Versus-Host Disease","status":"TERMINATED","sponsor":"Mallinckrodt","startDate":"2006-01","conditions":"Acute Graft-versus-Host Disease","enrollment":19},{"nctId":"NCT00639717","phase":"PHASE2","title":"Addition of Etanercept and Extracorporeal Photopheresis (ECP) to Standard Graft-Versus-Host Disease (GVHD) Prophylaxis 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Used for Cutaneous T-cell lymphoma (mycosis fungoides), Peripheral T-cell lymphoma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}