{"id":"methoxamine","rwe":[],"tags":[{"label":"methoxamine","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Alpha-1A adrenergic receptor","category":"target"},{"label":"ADRA1A","category":"gene"},{"label":"ADRA1D","category":"gene"},{"label":"ADRA1B","category":"gene"},{"label":"C01CA10","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Low blood pressure","category":"indication"},{"label":"Paroxysmal supraventricular tachycardia","category":"indication"},{"label":"Glaxosmithkline","category":"company"},{"label":"Adrenergic Agents","category":"pharmacology"},{"label":"Adrenergic Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-1 Receptor Agonists","category":"pharmacology"},{"label":"Adrenergic alpha-Agonists","category":"pharmacology"},{"label":"Cardiovascular Agents","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"},{"label":"Sympathomimetics","category":"pharmacology"},{"label":"Vasoconstrictor Agents","category":"pharmacology"}],"phase":"marketed","safety":{},"trials":[],"aliases":[],"company":"GSK","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=METHOXAMINE","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T03:47:36.682839+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T03:47:47.853146+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHOXAMINE","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T03:47:48.625016+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: Adrenergic receptor alpha-1 agonist","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:47:49.211929+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL1201103/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T03:47:49.110522+00:00"}},"allNames":"methoxamin","offLabel":[],"synonyms":["methoxamine","methoxamin","methoxamine hydrochloride","methoxamine HCl"],"timeline":[],"aiSummary":"Methoxamine, also known as Methoxamine, is a small molecule drug developed by GlaxoSmithKline that targets the alpha-1A adrenergic receptor. It is used to treat low blood pressure and paroxysmal supraventricular tachycardia. As an off-patent medication, it is no longer protected by active patents, but its generic status is uncertain due to the lack of generic manufacturers. Methoxamine works by stimulating the alpha-1A adrenergic receptor, which increases blood pressure and heart rate. It is a valuable treatment option for patients with these conditions, but its commercial status and availability may be limited.","approvals":[{"date":"","orphan":false,"company":"GLAXOSMITHKLINE","regulator":"FDA"}],"brandName":"Methoxamin","ecosystem":[{"indication":"Low blood pressure","otherDrugs":[{"name":"dopamine","slug":"dopamine","company":""},{"name":"epinephrine","slug":"epinephrine","company":""},{"name":"mephentermine","slug":"mephentermine","company":"Baxter Hlthcare Corp"},{"name":"metaraminol","slug":"metaraminol","company":""}],"globalPrevalence":null},{"indication":"Paroxysmal supraventricular tachycardia","otherDrugs":[{"name":"adenosine","slug":"adenosine","company":"Astellas"},{"name":"diltiazem","slug":"diltiazem","company":"Valeant Intl"},{"name":"ganciclovir","slug":"ganciclovir","company":"Roche Palo"},{"name":"propafenone","slug":"propafenone","company":"Glaxosmithkline Llc"}],"globalPrevalence":null}],"mechanism":{"target":"Alpha-1A adrenergic receptor","novelty":"First-in-class","targets":[{"gene":"ADRA1A","source":"DrugCentral","target":"Alpha-1A adrenergic receptor","protein":"Alpha-1A adrenergic receptor"},{"gene":"ADRA1D","source":"DrugCentral","target":"Alpha-1D adrenergic receptor","protein":"Alpha-1D adrenergic receptor"},{"gene":"ADRA1B","source":"DrugCentral","target":"Alpha-1B adrenergic receptor","protein":"Alpha-1B adrenergic receptor"}],"modality":"Small Molecule","drugClass":"methoxamine","explanation":"","oneSentence":"","technicalDetail":"Methoxamine acts as an agonist at the alpha-1A adrenergic receptor, triggering a cascade of intracellular signaling events that ultimately lead to vasoconstriction and increased blood pressure."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1753","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=METHOXAMINE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHOXAMINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange 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