{"id":"methotrexate-therapy","safety":{"commonSideEffects":[{"rate":"20-40","effect":"Myelosuppression (neutropenia, thrombocytopenia, anemia)"},{"rate":"10-30","effect":"Mucositis"},{"rate":"5-15","effect":"Hepatotoxicity"},{"rate":"5-10","effect":"Nephrotoxicity"},{"rate":"20-30","effect":"Nausea and vomiting"},{"rate":"10-20","effect":"Alopecia"},{"rate":"10-25","effect":"Infection"}]},"_chembl":{"chemblId":"CHEMBL2074969","moleculeType":"Small molecule","molecularWeight":"841.79"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methotrexate is a folate antagonist that inhibits dihydrofolate reductase, an enzyme critical for converting dihydrofolate to tetrahydrofolate, which is essential for one-carbon transfer reactions in nucleotide synthesis. By depleting intracellular folate cofactors, it suppresses DNA and RNA synthesis, leading to reduced cell proliferation. At lower doses used in rheumatologic and pediatric conditions, it also has immunosuppressive and anti-inflammatory effects through adenosine release and other mechanisms.","oneSentence":"Methotrexate inhibits dihydrofolate reductase, blocking folate metabolism and reducing DNA synthesis and cell proliferation.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:43.492Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL) in pediatric patients"},{"name":"Osteosarcoma"},{"name":"Rheumatoid arthritis"},{"name":"Juvenile idiopathic arthritis"},{"name":"Various pediatric malignancies"}]},"trialDetails":[{"nctId":"NCT06317662","phase":"PHASE2","title":"Testing the Addition of the Anti-cancer Drug Venetoclax and/or the Anti-cancer Immunotherapy Blinatumomab to the Usual Chemotherapy Treatment for Infants With Newly Diagnosed KMT2A-rearranged or KMT2A-non-rearranged Leukemia","status":"RECRUITING","sponsor":"National 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