{"id":"methotrexate-misoprostol","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal cramping and diarrhea"},{"rate":null,"effect":"Bone marrow suppression"},{"rate":null,"effect":"Hepatotoxicity"},{"rate":null,"effect":"Nephrotoxicity"},{"rate":null,"effect":"Mucositis"},{"rate":null,"effect":"Vaginal bleeding (in abortion context)"}]},"_chembl":{"chemblId":"CHEMBL4064157","moleculeType":"Small molecule","molecularWeight":"382.54"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methotrexate is an antimetabolite that blocks folate metabolism, leading to inhibition of DNA synthesis and cell division. Misoprostol is a prostaglandin analog that enhances gastric and intestinal mucosal protection by increasing mucus production and bicarbonate secretion, thereby reducing the risk of methotrexate-induced gastrointestinal toxicity and ulceration.","oneSentence":"Methotrexate inhibits dihydrofolate reductase to suppress cell proliferation, while misoprostol protects the gastrointestinal mucosa from methotrexate-induced damage.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:41.326Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Medical abortion (methotrexate-misoprostol combination)"},{"name":"Ectopic pregnancy"},{"name":"Rheumatoid arthritis (methotrexate with gastroprotection)"}]},"trialDetails":[{"nctId":"NCT02680314","phase":"PHASE2","title":"Is More Than One Dose of Misoprostol Needed to Expedite Vaginal Delivery in a Patient With an Unripe Cervix?","status":"COMPLETED","sponsor":"Montefiore Medical Center","startDate":"2016-02","conditions":"Labor; Forced or Induced, Affecting Fetus or Newborn","enrollment":243},{"nctId":"NCT00129506","phase":"PHASE4","title":"Comparing Methotrexate Followed by Misoprostol to Misoprostol Alone for Early Abortion","status":"COMPLETED","sponsor":"Wiebe, Ellen, M.D.","startDate":"2005-05","conditions":"Unwanted Pregnancies","enrollment":300},{"nctId":"NCT01943279","phase":"NA","title":"Comparison of Telephone Follow-up With In-person Follow-up After Medical Abortion","status":"COMPLETED","sponsor":"Women's College Hospital","startDate":"2011-07","conditions":"Medical; Abortion, Fetus","enrollment":139}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":19,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"methotrexate + misoprostol","genericName":"methotrexate + misoprostol","companyName":"Wiebe, Ellen, M.D.","companyId":"wiebe-ellen-m-d","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methotrexate inhibits dihydrofolate reductase to suppress cell proliferation, while misoprostol protects the gastrointestinal mucosa from methotrexate-induced damage. Used for Medical abortion (methotrexate-misoprostol combination), Ectopic pregnancy, Rheumatoid arthritis (methotrexate with gastroprotection).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}