{"id":"methotrexate-1-topical-gel","safety":{"commonSideEffects":[{"rate":null,"effect":"Local skin irritation"},{"rate":null,"effect":"Erythema"},{"rate":null,"effect":"Pruritus"},{"rate":null,"effect":"Burning sensation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"As a topical formulation, methotrexate penetrates skin tissue to inhibit dihydrofolate reductase, disrupting purine and pyrimidine synthesis. This reduces proliferation of keratinocytes and immune cells in the dermis and epidermis. The anti-inflammatory and immunosuppressive properties make it effective for inflammatory and proliferative skin conditions.","oneSentence":"Methotrexate inhibits dihydrofolate reductase, blocking folate metabolism and reducing DNA synthesis in rapidly dividing cells, with immunosuppressive and anti-inflammatory effects when applied topically.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:49.800Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Psoriasis"},{"name":"Inflammatory skin conditions"},{"name":"Cutaneous T-cell lymphoma (mycosis fungoides)"}]},"trialDetails":[{"nctId":"NCT07459933","phase":"PHASE4","title":"Topical Methotrexate vs Minoxidil for Localized Alopecia Areata","status":"NOT_YET_RECRUITING","sponsor":"Jinnah Postgraduate Medical Centre","startDate":"2026-03-15","conditions":"Alopecia Areata","enrollment":268},{"nctId":"NCT07208890","phase":"NA","title":"Methotrexate Iontophoresis Versus Methotrexate 1% Gel on Depigmentation in Vitiligo Patients","status":"NOT_YET_RECRUITING","sponsor":"Pharos University in Alexandria","startDate":"2025-11-10","conditions":"Vitiligo - Evaluation of Methotrexate Iontophoresis and Topical Methotrexate Gel as Localized Treatment Approache","enrollment":30},{"nctId":"NCT07021495","phase":"","title":"SKIN Disease Profiling by an Exploratory, pRospective, Biomarker Study in dermatoloGY Practice (SKINERGY)","status":"RECRUITING","sponsor":"Leiden University Medical Center","startDate":"2025-07-29","conditions":"Chronic Spontaneous Urticaria (CSU), Hidradenitis Suppurativa (HS), Psoriasis (PsO)","enrollment":840},{"nctId":"NCT06877455","phase":"NA","title":"Topical Methotrexate with Fractional CO2 Laser in Treatment of Non Segmental Vitiligo","status":"NOT_YET_RECRUITING","sponsor":"Assiut University","startDate":"2026-05-01","conditions":"Vitiligo","enrollment":50},{"nctId":"NCT06555497","phase":"EARLY_PHASE1","title":"Topical 1% Methotrexate Gel Versus Clobetasol Propionate in Patients With Psoriasis","status":"COMPLETED","sponsor":"Dr. Jose N. Rodriguez Memorial Hospital and Sanitarium","startDate":"2022-01-01","conditions":"Pilot Study, Psoriasis","enrollment":2},{"nctId":"NCT04942860","phase":"PHASE3","title":"The Evaluation of Vitiligous Lesions Repigmentation After Topical Administration of Methotrexate in Patients With Active Vitiligo","status":"COMPLETED","sponsor":"Nicolaus Copernicus University","startDate":"2019-10-01","conditions":"Non-segmental Vitiligo","enrollment":25},{"nctId":"NCT05300009","phase":"NA","title":"Efficacy and Safety of Topical Methotrexate Gel 1% Coupled With Microneedling in Treatment of Warts","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2022-06-15","conditions":"Warts","enrollment":68}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methotrexate 1% Topical Gel","genericName":"Methotrexate 1% Topical Gel","companyName":"Jinnah Postgraduate Medical Centre","companyId":"jinnah-postgraduate-medical-centre","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methotrexate inhibits dihydrofolate reductase, blocking folate metabolism and reducing DNA synthesis in rapidly dividing cells, with immunosuppressive and anti-inflammatory effects when applied topically. Used for Psoriasis, Inflammatory skin conditions, Cutaneous T-cell lymphoma (mycosis fungoides).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}