{"id":"methopromazine","rwe":[{"pmid":"35796590","year":"2022","title":"Thioarylation of anilines using dual catalysis: two-step synthesis of phenothiazines.","finding":"","journal":"Organic & biomolecular chemistry","studyType":"Clinical Study"},{"pmid":"18963412","year":"1983","title":"Application of methopromazine for the extractive spectrophotometric determination of platinum.","finding":"","journal":"Talanta","studyType":"Clinical Study"},{"pmid":"4387417","year":"1968","title":"[Variation in total arterial CO2 in guinea pigs subjected to a histamine aerosol. Modifications produced by methopromazine].","finding":"","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales","studyType":"Clinical Study"},{"pmid":"6010718","year":"1966","title":"[Pharmaceutical studies on phenothiazine derivatives. VI. Photodegradation of methopromazine, levomepromazine, and its sulfoxide].","finding":"","journal":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan","studyType":"Clinical Study"},{"pmid":"13906464","year":"1961","title":"[Remarkable tolerance to methopromazine in treatment continued for more than 5-years in unstable children].","finding":"","journal":"Revue de neuropsychiatrie infantile et d'hygiene mentale de l'enfance","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methoxypromazine","offLabel":[],"synonyms":["methoxypromazine","methopromazine","2-methopromazine"],"timeline":[],"approvals":[],"brandName":"Methoxypromazine","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Imagine your body's cells are like locks, and methoxypromazine is a key that fits into those locks. When it binds to the right receptors, it can help to regulate various bodily functions, such as mood or movement. This can lead to a range of therapeutic effects, but the exact details of how it works are still unclear.","oneSentence":"Methoxypromazine works by binding to specific receptors in the body to produce a therapeutic effect.","technicalDetail":"Methoxypromazine is a phenothiazine derivative that likely acts as a dopamine antagonist, although the specific molecular mechanisms underlying its effects are not well understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1756","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=methopromazine","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:38:33.160746","biosimilars":[],"competitors":[],"genericName":"methopromazine","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"A6F645Q9HQ","CHEBI":"CHEBI:135347","INN_ID":"592","UMLSCUI":"C0066143","ChEMBL_ID":"CHEMBL2110655","PUBCHEM_CID":"18847","SNOMEDCT_US":"48940005","MESH_SUPPLEMENTAL_RECORD_UI":"C008393"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":13,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2022 Jul 20","pmid":"35796590","title":"Thioarylation of anilines using dual catalysis: two-step synthesis of phenothiazines.","journal":"Organic & biomolecular chemistry"},{"date":"1983 Jul","pmid":"18963412","title":"Application of methopromazine for the extractive spectrophotometric determination of platinum.","journal":"Talanta"},{"date":"1968","pmid":"4387417","title":"[Variation in total arterial CO2 in guinea pigs subjected to a histamine aerosol. Modifications produced by methopromazine].","journal":"Comptes rendus des seances de la Societe de biologie et de ses filiales"},{"date":"1966 Jun","pmid":"6010718","title":"[Pharmaceutical studies on phenothiazine derivatives. VI. Photodegradation of methopromazine, levomepromazine, and its sulfoxide].","journal":"Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan"},{"date":"1961 Nov-Dec","pmid":"13906464","title":"[Remarkable tolerance to methopromazine in treatment continued for more than 5-years in unstable children].","journal":"Revue de neuropsychiatrie infantile et d'hygiene mentale de l'enfance"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Methoxypromazine, also known as methopromazine, is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it is not known whether it is FDA approved or off-patent. The approved indications for methoxypromazine are also unknown. As a small molecule, it is likely to work by interacting with specific biological molecules to produce a therapeutic effect. Further research is needed to fully understand its mechanism of action and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}