{"id":"methenamine-methylthioninium-acriflavine-atropa-belladona","safety":{"commonSideEffects":[{"rate":null,"effect":"Urinary discoloration (blue-green)"},{"rate":null,"effect":"Dry mouth"},{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Blurred vision"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL1201270","moleculeType":"Small molecule","molecularWeight":"140.19"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methenamine is converted to formaldehyde in acidic urine, providing broad-spectrum antimicrobial activity. Methylthioninium acts as an antimicrobial agent and may help with urinary discoloration and symptom relief. Acriflavine is an acridine dye with antimicrobial properties. Atropine provides anticholinergic effects to reduce urinary urgency, frequency, and dysuria by relaxing bladder smooth muscle.","oneSentence":"This combination product uses methenamine as a urinary antiseptic, methylthioninium (methylene blue) as an antimicrobial and urinary tract agent, acriflavine as a topical antimicrobial, and atropine (from Atropa belladonna) as an anticholinergic to reduce urinary symptoms.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:54:40.274Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Urinary tract infections and associated symptoms"},{"name":"Dysuria and urinary urgency/frequency"}]},"trialDetails":[{"nctId":"NCT03379389","phase":"PHASE4","title":"Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2018-03-31","conditions":"Urinary Tract Infections","enrollment":284}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["methenamine + methylene blue + acriflavine + A. belladona"],"phase":"marketed","status":"active","brandName":"Methenamine + Methylthioninium + Acriflavine + Atropa belladona","genericName":"Methenamine + Methylthioninium + Acriflavine + Atropa belladona","companyName":"Fundação Educacional Serra dos Órgãos","companyId":"funda-o-educacional-serra-dos-rg-os","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination product uses methenamine as a urinary antiseptic, methylthioninium (methylene blue) as an antimicrobial and urinary tract agent, acriflavine as a topical antimicrobial, and atropine (from Atropa belladonna) as an anticholinergic to reduce urinary symptoms. Used for Urinary tract infections and dysuria, Urinary frequency and urgency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}