{"id":"methenamine-methylthioninium","safety":{"commonSideEffects":[{"rate":null,"effect":"Discoloration of urine (blue-green)"},{"rate":null,"effect":"Gastrointestinal upset"},{"rate":null,"effect":"Dysuria"},{"rate":null,"effect":"Allergic reactions"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methenamine is a prodrug that hydrolyzes in acidic urine to release formaldehyde, which has broad-spectrum antimicrobial properties against bacteria and some fungi. Methylthioninium (methylene blue) is an oxidizing agent with antimicrobial and antioxidant properties that enhances urinary antisepsis. Together, they provide synergistic antimicrobial activity in the urinary tract.","oneSentence":"Methenamine releases formaldehyde in acidic urine to provide antimicrobial activity, while methylthioninium (methylene blue) acts as an additional antimicrobial and urinary antiseptic agent.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:44.770Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Urinary tract infections (prophylaxis and treatment)"},{"name":"Cystitis"}]},"trialDetails":[{"nctId":"NCT03379389","phase":"PHASE4","title":"Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2018-03-31","conditions":"Urinary Tract Infections","enrollment":284},{"nctId":"NCT01657448","phase":"PHASE3","title":"Efficacy Study of Methenamine + Methylthioninium Chloride vs Phenazopyridine for the Symptomatic Control of Dysuria","status":"COMPLETED","sponsor":"EMS","startDate":"2016-06-27","conditions":"Dysuria","enrollment":316}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["methenamine + methylene blue"],"phase":"marketed","status":"active","brandName":"Methenamine + Methylthioninium","genericName":"Methenamine + Methylthioninium","companyName":"Fundação Educacional Serra dos Órgãos","companyId":"funda-o-educacional-serra-dos-rg-os","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methenamine releases formaldehyde in acidic urine to provide antimicrobial activity, while methylthioninium (methylene blue) acts as an additional antimicrobial and urinary antiseptic agent. Used for Urinary tract infections (prophylaxis and treatment), Cystitis.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}