{"id":"methenamine-and-methylthioninium-chloride","safety":{"commonSideEffects":[{"rate":null,"effect":"Dysuria"},{"rate":null,"effect":"Urinary discoloration (blue-green)"},{"rate":null,"effect":"Nausea"},{"rate":null,"effect":"Abdominal discomfort"},{"rate":null,"effect":"Headache"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methenamine is a prodrug that hydrolyzes in acidic urine to release formaldehyde, which has broad-spectrum antimicrobial properties against bacteria and some fungi. Methylthioninium chloride (methylene blue) is an oxidizing agent with antimicrobial and antioxidant properties that enhances urinary antisepsis. Together, this combination targets urinary tract infections through dual antimicrobial mechanisms.","oneSentence":"Methenamine releases formaldehyde in acidic urine to provide antimicrobial activity, while methylthioninium chloride (methylene blue) acts as an antimicrobial agent and urinary antiseptic.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:50:03.022Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Urinary tract infections (prophylaxis and treatment)"},{"name":"Recurrent urinary tract infections"}]},"trialDetails":[{"nctId":"NCT03379389","phase":"PHASE4","title":"Clinical Assessment of Urinary Antiseptics Methenamine and Methylthioninium in Recurrent Cystitis","status":"COMPLETED","sponsor":"Fundação Educacional Serra dos Órgãos","startDate":"2018-03-31","conditions":"Urinary Tract Infections","enrollment":284},{"nctId":"NCT01657448","phase":"PHASE3","title":"Efficacy Study of Methenamine + Methylthioninium Chloride vs Phenazopyridine for the Symptomatic Control of Dysuria","status":"COMPLETED","sponsor":"EMS","startDate":"2016-06-27","conditions":"Dysuria","enrollment":316}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":2,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Methenamine and Methylthioninium chloride","genericName":"Methenamine and Methylthioninium chloride","companyName":"EMS","companyId":"ems","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methenamine releases formaldehyde in acidic urine to provide antimicrobial activity, while methylthioninium chloride (methylene blue) acts as an antimicrobial agent and urinary antiseptic. Used for Urinary tract infections (prophylaxis and treatment), Recurrent urinary tract infections.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":1,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}