{"id":"metharbital","rwe":[{"pmid":"34940636","year":"2021","title":"Metabolomics Insights into Chemical Convergence in Xanthomonas perforans and Metabolic Changes Following Treatment with the Small Molecule Carvacrol.","finding":"","journal":"Metabolites","studyType":"Clinical Study"},{"pmid":"15204036","year":"2004","title":"Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques.","finding":"","journal":"Receptors & channels","studyType":"Clinical Study"},{"pmid":"12897810","year":"2003","title":"Effects of barbiturates on human platelet aggregation differ depending on their chemical structures.","finding":"","journal":"Canadian journal of physiology and pharmacology","studyType":"Clinical Study"},{"pmid":"9050222","year":"1997","title":"Forensic analysis of 10 barbiturates in human biological samples using a new reversed-phase chromatographic column packed with 2-micrometre porous microspherical silica-gel.","finding":"","journal":"Forensic science international","studyType":"Clinical Study"},{"pmid":"7780992","year":"1995","title":"Synthesis of N-beta-D-glucopyranosyluronate derivatives of barbital, phenobarbital, metharbital, and mephobarbital.","finding":"","journal":"Carbohydrate research","studyType":"Clinical Study"}],"tags":[{"label":"metharbital","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"GABA-A receptor; anion channel","category":"target"},{"label":"GABRA1","category":"gene"},{"label":"GABRA2","category":"gene"},{"label":"GABRA3","category":"gene"},{"label":"N03AA30","category":"atc"},{"label":"Off-Patent","category":"patent"},{"label":"Active","category":"status"},{"label":"Epilepsy","category":"indication"},{"label":"Insomnia","category":"indication"},{"label":"Tonic-clonic epilepsy","category":"indication"},{"label":"Abbvie","category":"company"}],"phase":"marketed","safety":{"drugInteractions":[{"url":"/drug/ciclosporin","drug":"ciclosporin","action":"Monitor closely","effect":"May interact with Cyclosporine","source":"DrugCentral","drugSlug":"ciclosporin"}]},"trials":[],"aliases":[],"company":"AbbVie","patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=METHARBITAL","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:59:22.999366+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:59:29.977135+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHARBITAL","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:59:30.774513+00:00"},"mechanism.target_chembl":{"url":"","method":"api_direct","source":"ChEMBL mechanism: GABA-A receptor; anion channel positive allosteric modulator","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:59:31.367254+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL450/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:59:31.256522+00:00"}},"allNames":"metabarbital","offLabel":[],"synonyms":["metharbital","metabarbital","methabarbitone","metharbitone","methylbarbital","N-Methylbarbital"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"ABBVIE","regulator":"FDA"}],"brandName":"Metabarbital","ecosystem":[{"indication":"Epilepsy","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"carbamazepine","slug":"carbamazepine","company":"Novartis"},{"name":"diazepam","slug":"diazepam","company":"Roche"},{"name":"felbamate","slug":"felbamate","company":"Meda Pharms"}],"globalPrevalence":50000000},{"indication":"Insomnia","otherDrugs":[{"name":"amobarbital","slug":"amobarbital","company":""},{"name":"choline","slug":"choline","company":""},{"name":"daridorexant","slug":"daridorexant","company":"Idorsia Pharmaceuticals Ltd"},{"name":"diphenhydramine","slug":"diphenhydramine","company":"Mcneil Cons"}],"globalPrevalence":750000000},{"indication":"Tonic-clonic epilepsy","otherDrugs":[{"name":"carbamazepine","slug":"carbamazepine","company":"Novartis"},{"name":"ethotoin","slug":"ethotoin","company":"Recordati Rare"},{"name":"phenytoin","slug":"phenytoin","company":"Parke Davis"},{"name":"primidone","slug":"primidone","company":"Valeant"}],"globalPrevalence":50000000}],"mechanism":{"target":"GABA-A receptor; anion channel","novelty":"First-in-class","targets":[{"gene":"GABRA1","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-1"},{"gene":"GABRA2","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-2"},{"gene":"GABRA3","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-3"},{"gene":"GABRA4","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-4"},{"gene":"GABRA5","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-5"},{"gene":"GABRA6","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit alpha-6"},{"gene":"GABRB1","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit beta-1"},{"gene":"GABRB2","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit beta-2"},{"gene":"GABRB3","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit beta-3"},{"gene":"GABRD","source":"DrugCentral","target":"GABA-A receptor; anion channel","protein":"Gamma-aminobutyric acid receptor subunit delta"}],"modality":"Small Molecule","drugClass":"metharbital","explanation":"","oneSentence":"","technicalDetail":"Metabarbital acts as a barbiturate that modulates the GABA-A receptor, an anion channel, to enhance the inhibitory effects of GABA, leading to a decrease in neuronal excitability and a reduction in seizure activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1740","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHARBITAL","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://www.fda.gov/drugs/drug-approvals-and-databases/orange-book-data-files","fields":["patents","exclusivity","genericManufacturers"],"source":"FDA Orange Book"}],"_enrichedAt":"2026-03-30T12:37:38.474815","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:59:33.121137+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"primidone","drugSlug":"primidone","fdaApproval":"1954-03-08","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"metharbital","indications":{"approved":[{"name":"Epilepsy","source":"DrugCentral","snomedId":84757009,"regulator":"FDA","usPrevalence":3400000,"globalPrevalence":50000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"},{"name":"Insomnia","source":"DrugCentral","snomedId":193462001,"regulator":"FDA","usPrevalence":70000000,"globalPrevalence":750000000,"prevalenceMethod":"curated","prevalenceSource":"Sleep Medicine Reviews, 2023"},{"name":"Tonic-clonic epilepsy","source":"DrugCentral","snomedId":352818000,"regulator":"FDA","usPrevalence":3400000,"globalPrevalence":50000000,"prevalenceMethod":"curated","prevalenceSource":"WHO, 2023"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"patentStatus":"Off-patent — no active Orange Book patents","relatedDrugs":[{"drugId":"primidone","brandName":"primidone","genericName":"primidone","approvalYear":"1954","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"_patentsChecked":true,"crossReferences":{"NUI":"N0000147034","NDDF":"001419","UNII":"02OS7K758T","VUID":"4018729","CHEBI":"CHEBI:31827","VANDF":"4018729","INN_ID":"2","RXNORM":"6825","UMLSCUI":"C0025629","chemblId":"CHEMBL450","ChEMBL_ID":"CHEMBL450","KEGG_DRUG":"D01382","DRUGBANK_ID":"DB00463","PDB_CHEM_ID":"VOK","PUBCHEM_CID":"4099","SNOMEDCT_US":"30676006","IUPHAR_LIGAND_ID":"7230","MESH_SUPPLEMENTAL_RECORD_UI":"C084822"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[{"period":"","companyName":"Abbvie","relationship":"Original Developer"}],"publicationCount":20,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"N03AA30","allCodes":["N03AA30"]},"biosimilarFilings":[],"originalDeveloper":"Abbvie","recentPublications":[{"date":"2021 Dec 16","pmid":"34940636","title":"Metabolomics Insights into Chemical Convergence in Xanthomonas perforans and Metabolic Changes Following Treatment with the Small Molecule Carvacrol.","journal":"Metabolites"},{"date":"2004","pmid":"15204036","title":"Evaluation of pyridine-3-carboxylic acid as a drug carrier by utilizing multivariate methods, structure property correlations, and pattern recognition techniques.","journal":"Receptors & channels"},{"date":"2003 Aug","pmid":"12897810","title":"Effects of barbiturates on human platelet aggregation differ depending on their chemical structures.","journal":"Canadian journal of physiology and pharmacology"},{"date":"1997 Feb 7","pmid":"9050222","title":"Forensic analysis of 10 barbiturates in human biological samples using a new reversed-phase chromatographic column packed with 2-micrometre porous microspherical silica-gel.","journal":"Forensic science international"},{"date":"1995 Apr 19","pmid":"7780992","title":"Synthesis of N-beta-D-glucopyranosyluronate derivatives of barbital, phenobarbital, metharbital, and mephobarbital.","journal":"Carbohydrate research"}],"companionDiagnostics":[],"genericManufacturers":0,"_genericFilersChecked":true,"genericManufacturerList":[],"status":"approved","companyName":"AbbVie","companyId":"abbvie","modality":"Small molecule","firstApprovalDate":"1982","aiSummary":"","enrichmentLevel":3,"visitCount":1,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"ABBVIE","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:59:33.121137+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"enriching","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":false,"score":1}}