{"id":"methaniazide","rwe":[],"tags":[{"label":"methaniazide","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"neotizide","offLabel":[],"synonyms":["methaniazide","methanizide","neotizide","isoniazide methanesulfonate","methaniazide sodium","isoniazid mesylate","isoniazid mesilate"],"timeline":[],"approvals":[],"brandName":"Neotizide","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"methaniazide","explanation":"Think of the thyroid gland like a factory that uses iodine to make hormones. Neotizide blocks the machinery that helps the factory use iodine, which can help reduce the amount of hormones produced. This can be helpful in treating conditions where hormone production is too high.","oneSentence":"Neotizide works by inhibiting the enzyme responsible for converting iodine into a form that can be used by the thyroid gland.","technicalDetail":"Neotizide is a competitive inhibitor of the iodide oxidase enzyme, which is involved in the synthesis of thyroid hormones. By blocking this enzyme, Neotizide reduces the amount of iodine available for hormone production, leading to decreased thyroid hormone levels."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Methaniazide","title":"Methaniazide","extract":"Methaniazide, brand name Neotizide among others, is an antibiotic which was used in the treatment of tuberculosis. It is a derivative of methanesulfonic acid and isoniazid, which is also an antituberculosis drug but has comparatively been far more widely known and used. Isoniazid is a prodrug of isonicotinic acid, and acetylisoniazid, a metabolite of isoniazid, is a metabolic intermediate through which most of the isonicotinic acid is formed. Methaniazide features its mesylate group at the same position as that of the acetyl group in acetylisoniazid, and so methaniazide probably acts as a prodrug of isonicotinic acid similarly to isoniazid and acetylisoniazid. Methaniazide is used as the sodium salt. It was never approved for use or sale in the United States."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1735","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHANIAZIDE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Methaniazide","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:07:01.195682","biosimilars":[],"competitors":[],"genericName":"methaniazide","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"GN8S7ZES0F","CHEBI":"CHEBI:134943","INN_ID":"1769","UMLSCUI":"C0066090","ChEMBL_ID":"CHEMBL2105190","KEGG_DRUG":"D08198","PUBCHEM_CID":"3769","SECONDARY_CAS_RN":"3804-89-5","MESH_SUPPLEMENTAL_RECORD_UI":"C061382"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":0,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Neotizide, also known as Methaniazide, is a small molecule drug in the methaniazide class. Unfortunately, there is limited information available on this compound. It is not clear what specific target it interacts with or what conditions it is used to treat. Neotizide's commercial status and safety considerations are also unknown. Further research is needed to fully understand its properties and potential applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}