{"id":"methallenestril","rwe":[{"pmid":"38846566","year":"2024","title":"Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics.","finding":"","journal":"Frontiers in microbiology","studyType":"Clinical Study"},{"pmid":"4002442","year":"1985","title":"Lipid-lowering effects of two synthetic oestrogen derivatives with weak genital oestrogen properties.","finding":"","journal":"Upsala journal of medical sciences","studyType":"Clinical Study"},{"pmid":"6659184","year":"1983","title":"Normalization of hypercalcaemia of primary hyperparathyroidism by treatment with methallenestril, a synthetic oestrogen with low oestrogenicity.","finding":"","journal":"Urologia internationalis","studyType":"Clinical Study"},{"pmid":"7202317","year":"1982","title":"Oestrogens and anti-oestrogens show dissociation between early uterine vascular responses and uterotrophic effects in mice.","finding":"","journal":"Acta endocrinologica","studyType":"Clinical Study"},{"pmid":"13504662","year":"1958","title":"Suppression of lactation with methallenestril.","finding":"","journal":"Obstetrics and gynecology","studyType":"Clinical Study"}],"tags":[{"label":"methallenestril","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"G03CB03","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"novestrine","offLabel":[],"synonyms":["methallenestril","methallenestrol","novestrine","vallestril"],"timeline":[],"approvals":[],"brandName":"Novestrine","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"methallenestril","explanation":"Imagine your body's cells have locks on them, and Novestrine has a key that fits into those locks. When it binds to the lock, it sends a signal that helps to treat a certain medical condition. However, the exact lock and signal it uses are not well understood.","oneSentence":"Novestrine works by interacting with a specific biological target to produce a therapeutic effect.","technicalDetail":"Novestrine is a small molecule that binds to a specific protein or receptor, triggering a downstream response that leads to its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1731","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METHALLENESTRIL","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:37:04.626978","biosimilars":[],"competitors":[{"drugName":"dienestrol","drugSlug":"dienestrol","fdaApproval":"1947-01-09","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"diethylstilbestrol","drugSlug":"diethylstilbestrol","fdaApproval":"1973-05-30","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"genericName":"methallenestril","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"dienestrol","brandName":"dienestrol","genericName":"dienestrol","approvalYear":"1947","relationship":"same-class"},{"drugId":"diethylstilbestrol","brandName":"diethylstilbestrol","genericName":"diethylstilbestrol","approvalYear":"1973","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001283","UNII":"XL025389JS","CHEBI":"CHEBI:6808","INN_ID":"35","UMLSCUI":"C0066078","ChEMBL_ID":"CHEMBL1697842","DRUGBANK_ID":"DB13143","PUBCHEM_CID":"10599","SNOMEDCT_US":"126174006","MESH_SUPPLEMENTAL_RECORD_UI":"C005194"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":8,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G03CB03","allCodes":["G03CB03","G03CC03"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024","pmid":"38846566","title":"Irisin alleviated the reproductive endocrinal disorders of PCOS mice accompanied by changes in gut microbiota and metabolomic characteristics.","journal":"Frontiers in microbiology"},{"date":"1985","pmid":"4002442","title":"Lipid-lowering effects of two synthetic oestrogen derivatives with weak genital oestrogen properties.","journal":"Upsala journal of medical sciences"},{"date":"1983","pmid":"6659184","title":"Normalization of hypercalcaemia of primary hyperparathyroidism by treatment with methallenestril, a synthetic oestrogen with low oestrogenicity.","journal":"Urologia internationalis"},{"date":"1982 Jun","pmid":"7202317","title":"Oestrogens and anti-oestrogens show dissociation between early uterine vascular responses and uterotrophic effects in mice.","journal":"Acta endocrinologica"},{"date":"1958 Feb","pmid":"13504662","title":"Suppression of lactation with methallenestril.","journal":"Obstetrics and gynecology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Novestrine, also known as methallenestril, is a small molecule drug of the methallenestril class. Its target and exact mechanism of action are unknown. It is not clear if Novestrine has been approved by the FDA or if it is commercially available. Further information on its commercial status, safety considerations, and pharmacological properties is not available.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}