{"id":"methadone-nac","safety":{"commonSideEffects":[{"rate":null,"effect":"Constipation"},{"rate":null,"effect":"Sedation"},{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"QT prolongation"},{"rate":null,"effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL651","moleculeType":"Small molecule","molecularWeight":"309.45"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methadone acts as a long-acting mu opioid receptor agonist, providing sustained analgesia and opioid replacement therapy. NAC is included as an adjunctive agent to reduce oxidative stress and potentially mitigate some adverse effects associated with chronic methadone use, such as neurotoxicity and organ damage. This combination approach aims to optimize pain management or opioid dependence treatment while reducing harm.","oneSentence":"Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system, while NAC (N-acetylcysteine) is an antioxidant that replenishes glutathione and may modulate opioid-related neurotoxicity.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:39.504Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Chronic pain management"},{"name":"Opioid use disorder / opioid maintenance therapy"}]},"trialDetails":[{"nctId":"NCT03952455","phase":"NA","title":"Deep Brain Stimulation of the Bilateral Nucleus Accumbens for Patients With Methadone Maintenance Treatment","status":"UNKNOWN","sponsor":"Ruijin Hospital","startDate":"2019-05-13","conditions":"Addiction Opiate","enrollment":12},{"nctId":"NCT01047956","phase":"PHASE4","title":"Compare Methadone Combined With N-Acetyl-Cysteine (NAC) and Methadone Alone for Opioids Astaining","status":"UNKNOWN","sponsor":"Taichung Veterans General Hospital","startDate":"2009-06","conditions":"Opioids Use","enrollment":60}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":13,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methadone; NAC","genericName":"Methadone; NAC","companyName":"Taichung Veterans General Hospital","companyId":"taichung-veterans-general-hospital","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methadone is a synthetic opioid agonist that binds to mu opioid receptors in the central nervous system, while NAC (N-acetylcysteine) is an antioxidant that replenishes glutathione and may modulate opioid-related neurotoxicity. Used for Opioid use disorder maintenance treatment, Chronic pain management.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}