{"id":"methadone-dexmedetomidine-ketamine-combination","safety":{"commonSideEffects":[{"rate":null,"effect":"Respiratory depression"},{"rate":null,"effect":"Hypotension"},{"rate":null,"effect":"Bradycardia"},{"rate":null,"effect":"Dissociative effects"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methadone provides opioid-mediated analgesia and sedation. Dexmedetomidine enhances sedation and analgesia through alpha-2 adrenergic receptor activation while maintaining airway reflexes. Ketamine contributes dissociative anesthesia and analgesia via NMDA receptor antagonism. The combination is designed to provide balanced anesthesia with reduced individual drug requirements.","oneSentence":"This combination uses methadone (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and ketamine (NMDA antagonist) together to produce anesthesia and analgesia.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:54:49.341Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Anesthesia and analgesia (specific clinical applications not clearly defined in available literature)"}]},"trialDetails":[{"nctId":"NCT07365800","phase":"PHASE4","title":"The MDK Study: Using a Combination of Methadone-dexmedetomidine-ketamine for Postoperative Pain Control in Patients Undergoing Complex Spine Surgeries.","status":"NOT_YET_RECRUITING","sponsor":"University of Missouri-Columbia","startDate":"2026-03-02","conditions":"Spine Surgery","enrollment":248},{"nctId":"NCT06985069","phase":"NA","title":"Outcome of Multimodal Anesthesia Bern","status":"COMPLETED","sponsor":"Insel Gruppe AG, University Hospital Bern","startDate":"2025-06-16","conditions":"Opioid Use, Pain, Postoperative, Postoperative Complications","enrollment":240}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1173899,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methadone-dexmedetomidine-ketamine combination","genericName":"Methadone-dexmedetomidine-ketamine combination","companyName":"University of Missouri-Columbia","companyId":"university-of-missouri-columbia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses methadone (opioid agonist), dexmedetomidine (alpha-2 adrenergic agonist), and ketamine (NMDA antagonist) together to produce anesthesia and analgesia. Used for Anesthesia and analgesia (specific clinical applications not clearly defined in available literature).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}