{"id":"methadon","rwe":[],"tags":[],"phase":"discontinued","safety":{"boxedWarnings":[],"safetySignals":[],"drugInteractions":[],"commonSideEffects":[],"contraindications":["Acute abdominal pain","Acute exacerbation of asthma","Benign intracranial hypertension","Benign prostatic hyperplasia","Bradycardia","Chronic disease of respiratory system","Conduction disorder of the heart","Congenital long QT syndrome","Decreased respiratory function","Disease of liver","Disorder of gallbladder","Drug AND/OR toxin-induced diarrhea","Epilepsy","Hypercapnia","Hypothyroidism","Inflammatory bowel disease","Injury of head","Kidney disease","Low blood pressure","Mood swings","Paralytic ileus","Procedure on urinary system","Prolonged QT interval","Pseudomembranous enterocolitis","Substance abuse","Torsades de pointes","Urethral stricture"],"specialPopulations":{},"discontinuationRates":[],"seriousAdverseEvents":[]},"status":"discontinued","trials":["NCT00184496","NCT07092475","NCT01990573","NCT00356083","NCT05740657","NCT01150435"],"aliases":["Diskets","Methadone Intensol","Methadose"],"patents":[],"pricing":[],"offLabel":[],"timeline":[],"brandName":"Methadon","companyId":"university-of-utah","ecosystem":[],"mechanism":{"target":"Neuronal acetylcholine receptor subunit alpha-10, D(4) dopamine receptor, D(3) dopamine receptor","novelty":"","modality":"Small molecule","drugClass":"","explanation":"","oneSentence":"","technicalDetail":""},"commercial":null,"references":[],"biosimilars":[],"companyName":"University of Utah","competitors":[],"dataSources":[{"url":"https://clinicaltrials.gov","name":"ClinicalTrials.gov","fields":["trialDetails","trials"],"retrievedDate":"2026-04-07"},{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"Methadon","indications":{"approved":[{"name":"Opioid withdrawal","diseaseId":"opioid-withdrawal","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"},{"name":"Severe pain","diseaseId":"severe-pain","approvalDate":"","lineOfTherapy":"","approvalCountry":"United States"}],"offLabel":[],"pipeline":[]},"labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT00184496","phase":"Phase 3","title":"Switching From Morphine to Methadone. A Clinical, Pharmacological and Pharmacogenetic Study","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","isPivotal":true,"enrollment":42,"indication":"Cancer","completionDate":"2009-09"},{"nctId":"NCT07092475","phase":"Phase 3","title":"The Impact of Intraoperative Methadone on Postoperative Opioid Use","status":"WITHDRAWN","sponsor":"University of Utah","isPivotal":true,"enrollment":0,"indication":"Breast Cancer, Opioid Use","completionDate":"2025-11"},{"nctId":"NCT01990573","phase":"NA","title":"Methadone in Pediatric Anesthesia II","status":"COMPLETED","sponsor":"Washington University School of Medicine","isPivotal":false,"enrollment":51,"indication":"Pain","completionDate":"2018-06-30"},{"nctId":"NCT00356083","phase":"Phase 3","title":"Opioid Switching From Oral Slow Release Morphine to Oral Methadone May Improve Pain Control in Chronic Non-malignant Pain: a Nine-month Follow-up Study.","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","isPivotal":true,"enrollment":12,"indication":"Non-malignant Chronic Pain","completionDate":"2005-03"},{"nctId":"NCT05740657","phase":"N/A","title":"Evaluation of Opioids and Metabolites in Hair and Sweat of Pediatric Patients in a Monitored Clinical Context, by Means of Targeted Liquid Chromatography-tandem Mass Spectrometry","status":"COMPLETED","sponsor":"University of Zurich","isPivotal":false,"enrollment":150,"indication":"Opioid Use, Unspecified","completionDate":"2025-02-28"},{"nctId":"NCT01150435","phase":"N/A","title":"Driving Ability of Drug Dependant Patients in Maintenance Therapy","status":"COMPLETED","sponsor":"Hummel, Christiane","isPivotal":false,"enrollment":121,"indication":"Driving Ability","completionDate":"2010-06"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{"icon":"","route":"","frequency":"","formulation":""},"formularyStatus":[],"apiManufacturers":[],"developmentCodes":[],"ownershipHistory":[],"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"firstApprovalDate":"","companionDiagnostics":[],"firstApprovalCountry":null,"genericManufacturerList":[],"modality":"Small molecule","aiSummary":"","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}