{"id":"methacholine-provocholine","safety":{"commonSideEffects":[{"rate":null,"effect":"Bronchoconstriction"},{"rate":null,"effect":"Wheezing"},{"rate":null,"effect":"Shortness of breath"},{"rate":null,"effect":"Chest tightness"},{"rate":null,"effect":"Cough"}]},"_chembl":null,"_fixedAt":"2026-03-30T17:33:12.673591","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Methacholine mimics the action of acetylcholine by directly stimulating muscarinic receptors on bronchial smooth muscle, leading to airway constriction. This property makes it useful as a diagnostic agent to provoke airway hyperresponsiveness in patients suspected of having asthma or other obstructive airway diseases. The degree of bronchoconstriction in response to methacholine challenge correlates with airway hyperreactivity.","oneSentence":"Methacholine is a cholinergic agonist that binds to muscarinic acetylcholine receptors on airway smooth muscle, causing bronchoconstriction.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:43.777Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Diagnostic agent for methacholine challenge test to assess airway hyperresponsiveness in suspected asthma"}]},"_fixedFields":["pubmed(7)"],"trialDetails":[{"nctId":"NCT01478152","phase":"NA","title":"Effect of Ectoin® Inhalation Solution on Subjects With Mild Bronchial Asthma","status":"COMPLETED","sponsor":"Bitop AG","startDate":"2009-08","conditions":"Asthma","enrollment":18},{"nctId":"NCT07356310","phase":"","title":"Body Composition Related Evaluation of Airway Tone and Hyper-rEactivity Using Oscillometry","status":"NOT_YET_RECRUITING","sponsor":"University of Rochester","startDate":"2026-02-01","conditions":"Breathing, Lung Function Decreased, Asthma (Diagnosis)","enrollment":100},{"nctId":"NCT07288827","phase":"NA","title":"Examining Bronchial Hyperresponsiveness in Primary Ciliary Dyskinesia","status":"RECRUITING","sponsor":"Indiana University","startDate":"2023-05-04","conditions":"Primary Ciliary Dyskinesia, Healthy","enrollment":40},{"nctId":"NCT05992519","phase":"","title":"Diagnostic and Translational Values of Point-of-care Blood Eosinophils and Exhaled Nitric Oxide (FeNO) in People Referred by Primary Care for Suspected Asthma","status":"COMPLETED","sponsor":"Université de Sherbrooke","startDate":"2022-11-07","conditions":"Asthma, Asthma in Children, Diagnosis","enrollment":123},{"nctId":"NCT06433921","phase":"PHASE1","title":"A Study to Compare the Relative Potency of Salbutamol Administered Via Metered Dose Inhalers (MDI) Containing Propellants HFA-152a to HFA-134a in Mild Asthmatics Aged 18 to 65 Inclusive","status":"RECRUITING","sponsor":"GlaxoSmithKline","startDate":"2024-08-14","conditions":"Asthma, Mild Asthma","enrollment":84},{"nctId":"NCT04275648","phase":"NA","title":"Exercise Induced Bronchoconstriction and Field Tests","status":"COMPLETED","sponsor":"Karolinska Institutet","startDate":"2020-12-01","conditions":"Exercise Induced Bronchoconstriction, Asthma","enrollment":60},{"nctId":"NCT06836375","phase":"","title":"Pilot Study for the Application of Low Power External Bioelectronic Devices in the Diagnosis of Bronchial Asthma.","status":"NOT_YET_RECRUITING","sponsor":"Acurable Ltd.","startDate":"2025-09-27","conditions":"Asthma Bronchiale","enrollment":50},{"nctId":"NCT06154304","phase":"PHASE3","title":"BE Study of Albuterol Sulfate Inhalation Aerosol 90 mcg Per Actuation in Patients With Stable Mild Asthma","status":"COMPLETED","sponsor":"Cipla Ltd.","startDate":"2023-12-06","conditions":"Bronchial Asthma","enrollment":120},{"nctId":"NCT07031102","phase":"","title":"Methacholine Challenge Test in School Children With/Without Asthma RISKA","status":"RECRUITING","sponsor":"Helsinki University Central Hospital","startDate":"2024-11-06","conditions":"Asthma Bronchiale, Lung Function Tests, Bronchial Hyperresponsiveness","enrollment":260},{"nctId":"NCT07011394","phase":"","title":"Diagnosing Asthma With Clinically Accessible, Non-invasive, and Efficient Tests: a Child-inclusive Translational Investigation","status":"RECRUITING","sponsor":"Université de Sherbrooke","startDate":"2024-04-09","conditions":"Diagnosis, Inflammation, Asthma in Children","enrollment":123},{"nctId":"NCT03105843","phase":"PHASE4","title":"Sensory-Mechanical Responses to Eucapneic Voluntary Hyperventilation and Mannitol","status":"RECRUITING","sponsor":"Dr. Diane Lougheed","startDate":"2022-03-01","conditions":"Asthma, Cough, Cough Variant Asthma","enrollment":30},{"nctId":"NCT04912596","phase":"NA","title":"Pharmacodynamic Equivalence of the Test and Reference Metered Dose Inhalers (MDIs) Containing Albuterol Sulfate in Adult Patients With Stable Mild Asthma","status":"RECRUITING","sponsor":"Intech Biopharm Ltd.","startDate":"2022-08-15","conditions":"Mild Asthma","enrollment":148},{"nctId":"NCT06730620","phase":"PHASE4","title":"Bioequivalence Study of Methacholine Chloride","status":"COMPLETED","sponsor":"China-Japan Friendship Hospital","startDate":"2024-01-29","conditions":"Healthy People","enrollment":20},{"nctId":"NCT06725641","phase":"PHASE4","title":"Bioequivalence Study of Methacholine for Inhalation (pharmacodynamics)","status":"COMPLETED","sponsor":"China-Japan Friendship Hospital","startDate":"2024-02-24","conditions":"Asthma","enrollment":40},{"nctId":"NCT05977699","phase":"PHASE4","title":"Reversibility of Methacholine Induced Bronchoconstriction","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Saskatchewan","startDate":"2024-01-12","conditions":"Asthma","enrollment":20},{"nctId":"NCT06199830","phase":"","title":"A Case-control Study on the Differentiation Between Cough Variant Asthma and Chronic Cough","status":"COMPLETED","sponsor":"The First Affiliated Hospital of Zhejiang Chinese Medical University","startDate":"2022-03-01","conditions":"Asthma","enrollment":645},{"nctId":"NCT06509659","phase":"","title":"Methacholine Challenge Test (MCT) in Healthy Adults","status":"RECRUITING","sponsor":"Allergi- og Lungeklinikken, Elsinore","startDate":"2024-08-10","conditions":"Hyperreactive Airway Disease","enrollment":25},{"nctId":"NCT06578169","phase":"","title":"Initiation of Exogenous Female Sex Hormones and Airway Responsiveness to Methacholine - A Prospective Cohort Study","status":"NOT_YET_RECRUITING","sponsor":"Copenhagen University Hospital, Hvidovre","startDate":"2024-09-01","conditions":"Asthma","enrollment":300},{"nctId":"NCT00745043","phase":"NA","title":"Beta-Blocker in Chronic Obstructive Pulmonary Disease (COPD) Study","status":"COMPLETED","sponsor":"Waikato Hospital","startDate":"2005-05","conditions":"Chronic Obstructive Pulmonary Disease","enrollment":11},{"nctId":"NCT02696980","phase":"PHASE1, PHASE2","title":"PEEP as Rescue Therapy for Asthmatics With Elevated BMI","status":"COMPLETED","sponsor":"University of Vermont","startDate":"2016-04","conditions":"Asthma","enrollment":18},{"nctId":"NCT05775952","phase":"","title":"Airway Remodeling and Rhinovirus in Asthmatics","status":"RECRUITING","sponsor":"University of Calgary","startDate":"2011-09-01","conditions":"Asthma, Respiratory Disease","enrollment":24},{"nctId":"NCT05149885","phase":"NA","title":"A Feasibility Study of SenseGuard to Assess Airway Responsiveness During Methacholine Challenge Test (MCT)","status":"COMPLETED","sponsor":"NanoVation","startDate":"2021-11-04","conditions":"Asthma","enrollment":37},{"nctId":"NCT06034145","phase":"","title":"Methacholine Challenge Testing: Comparison of FEV1 and IOS Parameters in Adult Asthma Patients","status":"UNKNOWN","sponsor":"Allergi- og Lungeklinikken, Elsinore","startDate":"2023-11-01","conditions":"Bronchial Hyperreactivity","enrollment":500},{"nctId":"NCT05734261","phase":"NA","title":"Forced Oscillations Technique During a Metacholine Test in Children","status":"RECRUITING","sponsor":"University Hospital, Montpellier","startDate":"2023-09-07","conditions":"Asthma in Children","enrollment":112},{"nctId":"NCT05084222","phase":"PHASE4","title":"Use of Buventol Easyhaler and Bufomix Easyhaler in Methacoline Challenge Testing","status":"COMPLETED","sponsor":"Orion Corporation, Orion Pharma","startDate":"2021-11-11","conditions":"Asthma","enrollment":180},{"nctId":"NCT05870436","phase":"","title":"A Study on the Diagnostic Value of the Methacholine Choline Provocation Test in the Asthmatic Population","status":"UNKNOWN","sponsor":"jingping Zheng","startDate":"2023-05-19","conditions":"Asthma","enrollment":1100},{"nctId":"NCT05740748","phase":"PHASE2","title":"Tezepelumab and Methacholine Airway Hyperresponsiveness in Participants With Mild Allergic Asthma","status":"UNKNOWN","sponsor":"McMaster University","startDate":"2023-04-01","conditions":"Asthma, Allergic","enrollment":34},{"nctId":"NCT05634473","phase":"NA","title":"A Study to Evaluate the Sensitivity and Specificity of Inhaled Methacholine in Bronchial Provocation Test","status":"UNKNOWN","sponsor":"Chia Tai Tianqing Pharmaceutical Group Co., Ltd.","startDate":"2022-12","conditions":"Asthma","enrollment":280},{"nctId":"NCT02230189","phase":"PHASE2","title":"Study of the Inflammation and Airway Changes That Occur After Exposure to Allergen in Asthmatics","status":"COMPLETED","sponsor":"Prescott Woodruff","startDate":"2015-03","conditions":"Asthma","enrollment":28},{"nctId":"NCT05113615","phase":"PHASE4","title":"Regular Use Tiotropium and Tolerance to Bronchoprotection in Mild Asthma","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2021-12-13","conditions":"Asthma","enrollment":12},{"nctId":"NCT05292976","phase":"PHASE3","title":"Pharmacodynamic Bioequivalence Study of Albuterol Sulfate Inhalation Aerosol, 0.09 mg Albuterol Base/ Inhalation","status":"WITHDRAWN","sponsor":"Aurobindo Pharma Ltd","startDate":"2022-04","conditions":"Bronchial Asthma","enrollment":""},{"nctId":"NCT03825302","phase":"","title":"Prostaglandin E2 as a Critical Mediator of Sex Disparities in Asthma","status":"WITHDRAWN","sponsor":"Vanderbilt University Medical Center","startDate":"2021-12-01","conditions":"Asthma","enrollment":""},{"nctId":"NCT01064245","phase":"NA","title":"Physiology of Cough in Asthma: Comparison of Sensory-Mechanical Responses to Mannitol and Methacholine Challenge Tests","status":"COMPLETED","sponsor":"Dr. Diane Lougheed","startDate":"2010-02-01","conditions":"Asthma, Cough Variant Asthma","enrollment":29},{"nctId":"NCT01256086","phase":"PHASE2","title":"Relative Potency of Formoterol Novolizer® 12 µg Compared to Formoterol Aerolizer® 12 µg","status":"COMPLETED","sponsor":"MEDA Pharma GmbH & Co. KG","startDate":"2010-12","conditions":"Asthma","enrollment":44},{"nctId":"NCT03509259","phase":"","title":"Cardiovascular Diseases in Elderly Asthma","status":"UNKNOWN","sponsor":"Seoul National University Hospital","startDate":"2019-03-21","conditions":"Asthma","enrollment":72},{"nctId":"NCT02630511","phase":"NA","title":"Asthma Exacerbations and Vascular Function","status":"COMPLETED","sponsor":"University of Alberta","startDate":"2015-12","conditions":"Asthma","enrollment":52},{"nctId":"NCT03363698","phase":"","title":"MCT and Capsaicin Provocation Challenge in Diagnosis of Chronic Cough","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2020-12-31","conditions":"Cough, Cough Variant Asthma, Upper-Airway Cough Syndrome","enrollment":55},{"nctId":"NCT02360072","phase":"","title":"Airway Inflammation and Bronchial Hyperresponsiveness in Rhinitic Children With or Without Asthma","status":"COMPLETED","sponsor":"Guangzhou Institute of Respiratory Disease","startDate":"2014-09","conditions":"Rhinitis, Asthma, Inflammation","enrollment":280},{"nctId":"NCT04777383","phase":"NA","title":"The Effects of Iontophoresed Vasoactive Drugs on Cutaneus Blood Flow","status":"UNKNOWN","sponsor":"University Hospital, Linkoeping","startDate":"2019-04-01","conditions":"Cardiovascular Diseases, Vascular Diseases","enrollment":90},{"nctId":"NCT01993329","phase":"PHASE2","title":"A Study to Evaluate the Effect of Gefapixant (AF-219/MK-7264) on Methacholine Hyper-reactivity in Participants With Asthma (MK-7264-009)","status":"COMPLETED","sponsor":"Afferent Pharmaceuticals, Inc., a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA)","startDate":"2013-12-16","conditions":"Asthma","enrollment":20},{"nctId":"NCT02584257","phase":"PHASE3","title":"Pharmacodynamic Bioequivalence of Metered Dose Inhalers of Albuterol Sulfate in Patients With Stable Mild Asthma","status":"COMPLETED","sponsor":"Lupin, Inc.","startDate":"2016-04","conditions":"Mild Persistent Asthma","enrollment":217},{"nctId":"NCT04001465","phase":"NA","title":"Determining Baseline Respiratory Duty Cycles in Subjects With and Without Airway Hyperresponsiveness","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2019-05-14","conditions":"Airway Hyper Responsiveness","enrollment":34},{"nctId":"NCT04167280","phase":"PHASE4","title":"Regular Use Effect of Inhaled Ipratropium Bromide on Airway Responsiveness to Methacholine in Well-controlled Asthma","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2019-11-05","conditions":"Asthma","enrollment":12},{"nctId":"NCT03898466","phase":"PHASE4","title":"Effect of Fluticasone Furoate on Methacholine Challenge","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2018-10-30","conditions":"Asthma","enrollment":14},{"nctId":"NCT03135899","phase":"PHASE1","title":"BI 443651 Methacholine Challenge","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2017-05-18","conditions":"Asthma","enrollment":37},{"nctId":"NCT04137029","phase":"NA","title":"Methacholine, Long-acting M-cholinolytic and beta2-agonist on the Activity of Beta-receptors in Healthy Volunteers","status":"UNKNOWN","sponsor":"Federal State Budgetary Institution, Pulmonology Scientific Research Institute","startDate":"2019-04-24","conditions":"Health, Subjective, Hyperreactivity, Bronchial","enrollment":20},{"nctId":"NCT00903227","phase":"PHASE4","title":"Steroid Sparing Effect of Nasal Corticosteroid In Asthma And Rhinitis","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2006-12","conditions":"Asthma, Allergic Rhinitis","enrollment":25},{"nctId":"NCT04109534","phase":"NA","title":"Effect of a Dietary Fatty Acid Supplementation on Symptoms and Bronchial Inflammation in Patients With Asthma","status":"UNKNOWN","sponsor":"Stefan Zielen","startDate":"2019-10-01","conditions":"Allergic Asthma, Allergy to House Dust Mite","enrollment":60},{"nctId":"NCT00585260","phase":"EARLY_PHASE1","title":"Mannitol Bronchoprovocation Challenge Ancillary Study/ACRN","status":"COMPLETED","sponsor":"University of Wisconsin, Madison","startDate":"2007-12","conditions":"Asthma","enrollment":66},{"nctId":"NCT02624505","phase":"PHASE3","title":"Pharmacodynamic Bioequivalence of Metered Dose Inhalers of Albuterol Sulfate in Patients With Stable Mild Asthma","status":"COMPLETED","sponsor":"Cipla Ltd.","startDate":"2015-12","conditions":"Bronchial Asthma","enrollment":110},{"nctId":"NCT03102749","phase":"","title":"Mechanism and Dynamics of Bronchial Hyper-reactivity to Methacholine in Distal Airway on Obese Patients With Asthma","status":"COMPLETED","sponsor":"University Hospital, Montpellier","startDate":"2012-06","conditions":"Asthma","enrollment":35},{"nctId":"NCT03505489","phase":"PHASE3","title":"The Effect of Deep Inhalation on Mannitol Responsiveness","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2018-06-01","conditions":"Asthma","enrollment":26},{"nctId":"NCT00830505","phase":"PHASE4","title":"Fluticasone/Salmeterol (FP/SM) Versus Double the Dose Fluticasone (FP) in Patients With Mild to Moderate Asthma","status":"COMPLETED","sponsor":"University of Dundee","startDate":"2009-04","conditions":"Asthma","enrollment":38},{"nctId":"NCT03315000","phase":"PHASE4","title":"Effect of Vilanterol on Methacholine Challenge Results","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2017-10-13","conditions":"Asthma","enrollment":17},{"nctId":"NCT03108534","phase":"PHASE2","title":"A Study to Evaluate the Onset of Relief From Methacholine-induced Bronchoconstriction With CHF1535 NEXThaler in Asthmatic Patients.","status":"COMPLETED","sponsor":"Chiesi Farmaceutici S.p.A.","startDate":"2017-02-28","conditions":"Asthma","enrollment":65},{"nctId":"NCT03696602","phase":"","title":"More Relaxation by Deep Breath on Methacholine","status":"COMPLETED","sponsor":"Central Hospital, Nancy, France","startDate":"2006-07-01","conditions":"Childhood Asthma","enrollment":78},{"nctId":"NCT03062904","phase":"NA","title":"Search of a Paradoxical Fall in Maximum Expiratory Flow After Bronchodilation in Healthy Subjects","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2014-02","conditions":"Paradoxical Fall in Maximum Expiratory Flows","enrollment":65},{"nctId":"NCT02833727","phase":"","title":"Airway Inflammation and Disease Burden in Asthmatic Smokers","status":"UNKNOWN","sponsor":"Université de Montréal","startDate":"2016-09","conditions":"Asthma","enrollment":160},{"nctId":"NCT01659476","phase":"NA","title":"Bronchodilating and Bronchoprotective Effects of Deep Inspirations","status":"COMPLETED","sponsor":"Queen's University","startDate":"2012-10","conditions":"Asthma, Cough","enrollment":43},{"nctId":"NCT02502825","phase":"NA","title":"Comparison of Methacholine Bronchial Provocation With Wright and Devilbiss646 Nebulizers","status":"COMPLETED","sponsor":"Guangzhou Institute of Respiratory Disease","startDate":"2015-07","conditions":"Asthma","enrollment":22},{"nctId":"NCT01547286","phase":"NA","title":"Imaging Study of the Lungs During an Allergic Asthma Attack","status":"COMPLETED","sponsor":"Massachusetts General Hospital","startDate":"2012-05","conditions":"Asthma, Atopy","enrollment":7},{"nctId":"NCT03243110","phase":"","title":"The Economic Burden of Asthma in Canada","status":"COMPLETED","sponsor":"University of British Columbia","startDate":"2010-12","conditions":"Asthma","enrollment":613},{"nctId":"NCT02822859","phase":"NA","title":"A Comparison of Three Nebulizers for Standard Clinical and Research Use in Methacholine Challenge Testing","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2016-06","conditions":"Asthma","enrollment":60},{"nctId":"NCT02975258","phase":"","title":"Adiposity and Airway Inflammation in HIV-Associated Airway Disease","status":"COMPLETED","sponsor":"University of Pittsburgh","startDate":"2015-09","conditions":"Asthma, HIV, Adiposity","enrollment":102},{"nctId":"NCT01725360","phase":"PHASE4","title":"Change of Airway Hyperresponsiveness to Mannitol and Methacholine in Patients With Asthma","status":"COMPLETED","sponsor":"Cantonal Hosptal, Baselland","startDate":"2007-01","conditions":"Asthma","enrollment":17},{"nctId":"NCT03141814","phase":"","title":"Asthma Origins and Remission Study","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2015-10","conditions":"Asthma","enrollment":80},{"nctId":"NCT01759849","phase":"","title":"Effect of in Vitro Blocking the Common Beta Chain on Cell Viability in Asthma","status":"COMPLETED","sponsor":"Hamilton Health Sciences Corporation","startDate":"2012-11","conditions":"Asthma","enrollment":10},{"nctId":"NCT02953041","phase":"PHASE4","title":"Effect of a LAMA and a uLABA on the Methacholine Dose-response Curve","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2016-10","conditions":"Asthma","enrollment":31},{"nctId":"NCT02965482","phase":"NA","title":"Investigation of Novel Procedure for Methacholine Challenge Testing","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2016-11","conditions":"Asthma","enrollment":15},{"nctId":"NCT01629823","phase":"NA","title":"Effect of Positive Airway Pressure on Reducing Airway Reactivity in Patients With Asthma (CPAP)","status":"COMPLETED","sponsor":"American Lung Association Asthma Clinical Research Centers","startDate":"2012-07","conditions":"Asthma","enrollment":209},{"nctId":"NCT02097537","phase":"PHASE3","title":"Study of Methacholine Chloride Inhalation Challenge in Children With Bronchial Asthma","status":"COMPLETED","sponsor":"Santen Pharmaceutical Co., Ltd.","startDate":"2014-02","conditions":"Asthma","enrollment":10},{"nctId":"NCT01144910","phase":"","title":"The Long-term Prognosis of Moderate to Severe Bronchial Hyperresponsiveness (BHR) in Asthmatic Preschool Children","status":"WITHDRAWN","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2011-05","conditions":"Intrinsic Asthma, Allergic Asthma, Allergy","enrollment":""},{"nctId":"NCT00906867","phase":"","title":"Pulmonary Function Test, Bronchial Hyperresponsiveness and Quality of Life in Patients With Vocal Cord Dysfunction (VCD)","status":"COMPLETED","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2009-04","conditions":"Dyspnea","enrollment":25},{"nctId":"NCT01777867","phase":"","title":"Cough Reflex Sensitivity and Bronchial Hyper-responsiveness","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2012-12","conditions":"Gastroesophageal Reflux Disease, Chronic Cough, Broncho-hyperreactivity","enrollment":24},{"nctId":"NCT02322788","phase":"PHASE3","title":"Comparing the Efficacy of Bricanyl M2 and Bricanyl M3 at 0.5 and 1.5 mg Dose Levels, to Allow for a Switch From Bricanyl Turbuhaler M2 to Bricanyl Turbuhaler M3","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2015-03","conditions":"Asthma","enrollment":95},{"nctId":"NCT00368576","phase":"PHASE1","title":"A Study To Determine The Effect Of SB-480848 On Asthma","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2006-08","conditions":"Atherosclerosis","enrollment":67},{"nctId":"NCT02343419","phase":"NA","title":"Diagnostic Utility of Different Airway Resistance Assessment Techniques in the Methacholine Challenge Test","status":"COMPLETED","sponsor":"Medical University of Warsaw","startDate":"2014-11","conditions":"Bronchial Hyperreactivity, Abnormal Respiratory Airway Resistance","enrollment":46},{"nctId":"NCT02296489","phase":"","title":"An Association Between Asthma Severity and Capnography Parameters","status":"COMPLETED","sponsor":"Oridion","startDate":"2014-12","conditions":"Asthma","enrollment":73},{"nctId":"NCT01642745","phase":"PHASE4","title":"Mannitol (Aridol) and Methacholine (Provocholine) Responsiveness","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2011-11","conditions":"Asthma","enrollment":20},{"nctId":"NCT00748306","phase":"PHASE2","title":"Study in Mild Asthmatic Patients","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2008-12","conditions":"Asthma","enrollment":19},{"nctId":"NCT02410096","phase":"NA","title":"Bronchial Inflammation and Hyperresponsiveness After Oil Supplementation","status":"COMPLETED","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2015-04","conditions":"Exercise-induced Asthma","enrollment":73},{"nctId":"NCT02622243","phase":"PHASE4","title":"Duration of Long Acting Muscarinic Antagonist (LAMA) Bronchoprotection Against Methacholine Challenge","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2015-11","conditions":"Asthma","enrollment":13},{"nctId":"NCT01724307","phase":"NA","title":"Stimulation of the Cervical Sympathetic Ganglion for Treatment of Asthma","status":"COMPLETED","sponsor":"Jonathan Parsons","startDate":"2011-09","conditions":"Asthma","enrollment":1},{"nctId":"NCT01269528","phase":"","title":"Prospective Evaluation of the Efficacy of Palivizumab Administration in Children Born at 29-32 Weeks of Gestation","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2013-08","conditions":"Bronchial Hyperreactivity, Infant, Premature","enrollment":42},{"nctId":"NCT02574975","phase":"PHASE4","title":"Assessment of Airway Responsiveness and Treatment Efficacy in Asthmatics","status":"UNKNOWN","sponsor":"Zhujiang Hospital","startDate":"2015-04","conditions":"Asthma","enrollment":80},{"nctId":"NCT01847768","phase":"NA","title":"Human Rhinovirus Infection and Airway Remodeling Mediators","status":"TERMINATED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2013-04","conditions":"Asthma","enrollment":2},{"nctId":"NCT01919424","phase":"NA","title":"Comparison of the Methacholine PC20 Between the Trudell Aeroeclipse* II Ban Nebulizer and the Wright Nebulizer","status":"COMPLETED","sponsor":"McMaster University","startDate":"2011-04","conditions":"Asthma","enrollment":46},{"nctId":"NCT01699594","phase":"NA","title":"Change in Airway Responsiveness After Allergen Exposure","status":"COMPLETED","sponsor":"University of Saskatchewan","startDate":"2012-10","conditions":"Allergic Asthma","enrollment":11},{"nctId":"NCT01985789","phase":"PHASE4","title":"Anti-histamines and Methacholine Challenges.","status":"COMPLETED","sponsor":"Don Cockcroft","startDate":"2013-11","conditions":"Asthma","enrollment":12},{"nctId":"NCT02026492","phase":"NA","title":"Exercise Challenge in a Cold Chamber","status":"COMPLETED","sponsor":"Johann Wolfgang Goethe University Hospital","startDate":"2013-06","conditions":"Exercise-induced Asthma","enrollment":79},{"nctId":"NCT02100267","phase":"PHASE3","title":"A Study to Evaluate Efficacy and Safety of Methacholine Chloride Challenge Test in Diagnosis of Adult Asthma","status":"COMPLETED","sponsor":"Sanwa Kagaku Kenkyusho Co., Ltd.","startDate":"2014-04","conditions":"Asthma","enrollment":""},{"nctId":"NCT02199873","phase":"PHASE1","title":"Safety, Tolerability and Pharmacodynamics of BIIX 1 XX in Healthy Young Male Volunteers","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"1998-06","conditions":"Healthy","enrollment":24},{"nctId":"NCT02263976","phase":"PHASE1","title":"Safety, Tolerability, Pharmacodynamics and Pharmacokinetics of BEA 2180 BR in Healthy Male Subjects","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2003-08","conditions":"Healthy","enrollment":101},{"nctId":"NCT01907334","phase":"PHASE4","title":"Dose-Response of Salmeterol in Children","status":"COMPLETED","sponsor":"University of Florida","startDate":"2013-08","conditions":"Asthma","enrollment":10},{"nctId":"NCT01288482","phase":"PHASE4","title":"AeroEclipse II Agreement","status":"COMPLETED","sponsor":"The Hospital for Sick Children","startDate":"2010-11","conditions":"Asthma","enrollment":32},{"nctId":"NCT01648920","phase":"","title":"A Study to Explore the Utility of Fractional Exhaled Nitric Oxide (FeNO) Compared With Methacholine Challenge (MCC) Testing in the Assessment of Patients With Suspected But Undiagnosed Asthma","status":"COMPLETED","sponsor":"Aerocrine AB","startDate":"2012-06","conditions":"Asthma","enrollment":50},{"nctId":"NCT02104284","phase":"NA","title":"A Comparative Bronchial Provocation Study With Mannitol and Methacolinie in a Korean Population","status":"COMPLETED","sponsor":"BL&H Co., Ltd","startDate":"2011-07","conditions":"Asthma","enrollment":104},{"nctId":"NCT00491153","phase":"","title":"Sensitivity and Specificity of Aridol Challenge for a Diagnosis of Asthma by a Specialist Pulmonologist","status":"TERMINATED","sponsor":"St. Olavs Hospital","startDate":"2007-09","conditions":"Asthma","enrollment":35},{"nctId":"NCT00577733","phase":"","title":"Study of the Physiology of the Asthma of the Obese Subjects. Breathing Obesity Asthma Study (BOA)","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2008-01","conditions":"Asthma, Obesity","enrollment":204},{"nctId":"NCT01578824","phase":"NA","title":"Assessment Of Vitamin D Role In The Pathogenesis Of Asthma In Vitamin D Resistent Patients","status":"COMPLETED","sponsor":"Rambam Health Care Campus","startDate":"2011-03","conditions":"Asthma, Vitamin D Resistant Rickets","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":7,"recentPublications":[{"date":"2022 Apr","pmid":"33210567","title":"Usefulness of extended nitric oxide analysis in children with allergic rhinitis.","journal":"The Journal of asthma : official journal of the Association for the Care of Asthma"},{"date":"2018 Sep","pmid":"30088367","title":"Prevalence, Risk Factors and Cutoff Values for Bronchial Hyperresponsiveness to Provocholine in 7-Year-Old Children.","journal":"Allergy, asthma & immunology research"},{"date":"2016 Feb","pmid":"26923652","title":"[The Safety and efficacy of airway-hyperresponsiveness test for asthma using by SK-1211 (Methacholine Chloride)].","journal":"Arerugi = [Allergy]"},{"date":"2014 Feb","pmid":"23586502","title":"Developing alternative delivery systems for methacholine challenge tests.","journal":"Journal of aerosol medicine and pulmonary drug delivery"},{"date":"2000 Dec","pmid":"11117286","title":"Effects of provocholine and methacholine on airway responses.","journal":"Allergy"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Methacholine (Provocholine)","genericName":"Methacholine (Provocholine)","companyName":"University of Saskatchewan","companyId":"university-of-saskatchewan","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methacholine is a cholinergic agonist that binds to muscarinic acetylcholine receptors on airway smooth muscle, causing bronchoconstriction. Used for Diagnostic agent for methacholine challenge test to assess airway hyperresponsiveness in suspected asthma.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}