{"id":"metformin-testosterone-undecanoate","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (metformin)"},{"rate":null,"effect":"Polycythemia (testosterone)"},{"rate":null,"effect":"Hepatotoxicity risk"},{"rate":null,"effect":"Cardiovascular effects"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity through AMPK activation and mitochondrial effects. Testosterone undecanoate is a long-acting androgen replacement that restores physiological testosterone levels. The combination targets both insulin resistance and testosterone deficiency, which often co-occur in metabolic syndrome and related conditions.","oneSentence":"Metformin improves insulin sensitivity and glucose metabolism while testosterone undecanoate restores androgen levels, together addressing metabolic dysfunction and hypogonadism.","_ai_confidence":"low"},"_scrapedAt":"2026-03-28T01:21:05.748Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes with hypogonadism"},{"name":"Metabolic syndrome with testosterone deficiency"}]},"trialDetails":[{"nctId":"NCT02514629","phase":"PHASE3","title":"Testosterone, Metformin, or Both, for Hypogonadism in Obese Males","status":"COMPLETED","sponsor":"Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud","startDate":"2013-07-04","conditions":"Hypogonadism, Obesity","enrollment":107}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":3,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Metformin + Testosterone Undecanoate","genericName":"Metformin + Testosterone Undecanoate","companyName":"Fundación Pública Andaluza para la Investigación de Málaga en Biomedicina y Salud","companyId":"fundaci-n-p-blica-andaluza-para-la-investigaci-n-de-m-laga-en-biomedicina-y-salu","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metformin improves insulin sensitivity and glucose metabolism while testosterone undecanoate restores androgen levels, together addressing metabolic dysfunction and hypogonadism. Used for Type 2 diabetes with hypogonadism, Metabolic syndrome with testosterone deficiency.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}