{"id":"metformin-plus-yasmin","safety":{"commonSideEffects":[{"rate":"10–30%","effect":"Gastrointestinal disturbance (metformin)"},{"rate":"5–15%","effect":"Nausea"},{"rate":"5–10%","effect":"Headache (hormonal component)"},{"rate":"5–10%","effect":"Breast tenderness"},{"rate":"<0.1%","effect":"Lactic acidosis (metformin, rare)"}]},"_chembl":{"chemblId":"CHEMBL1431","moleculeType":"Small molecule","molecularWeight":"129.17"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin acts as a biguanide that decreases gluconeogenesis in the liver and enhances peripheral insulin sensitivity, thereby lowering blood glucose levels. Yasmin is an oral contraceptive containing a progestin (drospirenone) and estrogen (ethinyl estradiol) that prevents ovulation. The combination allows simultaneous management of metabolic dysfunction and pregnancy prevention in women requiring both interventions.","oneSentence":"This combination pairs metformin, which reduces hepatic glucose production and improves insulin sensitivity, with Yasmin (drospirenone/ethinyl estradiol), a hormonal contraceptive, to address both glycemic control and contraceptive needs in women with diabetes or prediabetes.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:55.916Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes or prediabetes in women requiring contraception"},{"name":"Polycystic ovary syndrome (PCOS) with metabolic dysfunction"}]},"trialDetails":[{"nctId":"NCT04984070","phase":"NA","title":"Research on Risk Factors and Interventions of Polycystic Ovary Syndrome Complicated With Depression and Anxiety","status":"UNKNOWN","sponsor":"Fudan University","startDate":"2021-01-01","conditions":"PCOS (Polycystic Ovary Syndrome) of Bilateral Ovaries, Depression, Anxiety","enrollment":100},{"nctId":"NCT00283816","phase":"PHASE3","title":"Impact of Metformin in Teens With Polycystic Ovary Syndrome (PCOS) on Oral Contraceptive Therapy","status":"COMPLETED","sponsor":"University of Rochester","startDate":"2006-01","conditions":"Polycystic Ovary Syndrome","enrollment":36},{"nctId":"NCT01581814","phase":"PHASE3","title":"Effects of Drospirenone-ethinylestradiol and/or Metformin on Cardiovascular Risk in Hyperinsulinemic Women With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Catholic University of the Sacred Heart","startDate":"2008-10","conditions":"Polycystic Ovary Syndrome","enrollment":99},{"nctId":"NCT01459445","phase":"NA","title":"Metformin+ Drospirenone/ethinylestradiol30µg and Flow-mediated Dilation in Polycystic Ovary Syndrome","status":"UNKNOWN","sponsor":"Iuliu Hatieganu University of Medicine and Pharmacy","startDate":"2011-02","conditions":"Polycystic Ovary Syndrome, Endothelial Dysfunction","enrollment":26}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":1,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"phase_3","status":"active","brandName":"Metformin plus Yasmin","genericName":"Metformin plus Yasmin","companyName":"Catholic University of the Sacred Heart","companyId":"catholic-university-of-the-sacred-heart","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination pairs metformin, which reduces hepatic glucose production and improves insulin sensitivity, with Yasmin (drospirenone/ethinyl estradiol), a hormonal contraceptive, to address both glycemic control and contraceptive needs in women with diabetes or prediabetes. Used for Type 2 diabetes or prediabetes in women requiring contraception, Polycystic ovary syndrome (PCOS) with metabolic dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}