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This combination is used to optimize glycemic control while mitigating metformin-associated micronutrient depletion.","oneSentence":"Metformin reduces hepatic glucose production and improves insulin sensitivity, while folic acid serves as a methyl donor and cofactor for nucleotide synthesis.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:37.947Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"}]},"trialDetails":[{"nctId":"NCT04892186","phase":"NA","title":"Effects of Myo-inositol in Women With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"University of Sao Paulo General Hospital","startDate":"2021-03-26","conditions":"Polycystic Ovary Syndrome, Resistance, Insulin, Glucose Intolerance","enrollment":60},{"nctId":"NCT01666730","phase":"PHASE2","title":"Metformin Plus Modified FOLFOX 6 in Metastatic Pancreatic Cancer","status":"COMPLETED","sponsor":"Case Comprehensive Cancer Center","startDate":"2013-02-21","conditions":"Acinar Cell Adenocarcinoma of the Pancreas, Duct Cell Adenocarcinoma of the Pancreas, Recurrent Pancreatic Cancer","enrollment":50},{"nctId":"NCT03711682","phase":"PHASE2, PHASE3","title":"Reducing Plasma Glucose Effect of Cinnamon in Type 2 Diabetic Patients in the Municipality of Comasagua","status":"COMPLETED","sponsor":"Universidad Dr. José Matías Delgado","startDate":"2018-03-01","conditions":"Type 2 Diabetes Mellitus","enrollment":30},{"nctId":"NCT04204044","phase":"EARLY_PHASE1","title":"Comparison of Myoinositol and Metformin in PCO","status":"UNKNOWN","sponsor":"Rashid Latif Medical College","startDate":"2020-11-01","conditions":"PCOS","enrollment":126},{"nctId":"NCT02302326","phase":"NA","title":"Involvement of Reticulum Endoplasmic Stress in the Physiopathology of Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana","startDate":"2013-01","conditions":"Polycystic Ovary Syndrome","enrollment":50},{"nctId":"NCT03259919","phase":"PHASE2","title":"Metformin Treatment of Pregnant Women With Polycystic Ovary Syndrome: a Pilot Study","status":"COMPLETED","sponsor":"Norwegian University of Science and Technology","startDate":"2000-10","conditions":"Polycystic Ovary Syndrome","enrollment":40},{"nctId":"NCT02786823","phase":"PHASE2, PHASE3","title":"Effect of Folic Acid and Vitamin B12 Supplementation in Subjects With Type 2 Diabetes","status":"COMPLETED","sponsor":"All India Institute of Medical Sciences, Bhubaneswar","startDate":"2017-05-01","conditions":"Diabetes Mellitus, Type 2","enrollment":80},{"nctId":"NCT02802215","phase":"PHASE2, PHASE3","title":"Metformin for Prevention Gestational Diabetes in Pregnant Women With Polycystic Ovarian Syndrome","status":"UNKNOWN","sponsor":"Ain Shams University","startDate":"2016-01","conditions":"Polycystic Ovary Syndrome, Diabetes, Gestational","enrollment":80},{"nctId":"NCT01759823","phase":"PHASE2, PHASE3","title":"Bone Marrow Derived Stem Cell Transplantation in T2DM","status":"COMPLETED","sponsor":"Post Graduate Institute of Medical Education and Research, Chandigarh","startDate":"2012-12","conditions":"Type 2 Diabetes Mellitus","enrollment":30},{"nctId":"NCT00670800","phase":"NA","title":"Study of Brain Function in Women With Insulin Resistant Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"University of Michigan","startDate":"2008-01","conditions":"Polycystic Ovary Syndrome","enrollment":14},{"nctId":"NCT01115140","phase":"PHASE4","title":"Metformin and Folate in Pregnant Polycystic Ovary Syndrome(PCOS) Women","status":"COMPLETED","sponsor":"University Magna Graecia","startDate":"2010-03","conditions":"Pregnancy, Polycystic Ovary Syndrome","enrollment":50},{"nctId":"NCT00953355","phase":"PHASE4","title":"Metformin and Folate Supplementation in Polycystic Ovary Syndrome (PCOS) Patients","status":"COMPLETED","sponsor":"University Magna Graecia","startDate":"2004-01","conditions":"Polycystic Ovary Syndrome, Anovulation","enrollment":50}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":11,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Metformin plus folic acid","genericName":"Metformin plus folic acid","companyName":"University Magna Graecia","companyId":"university-magna-graecia","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metformin reduces hepatic glucose production and improves insulin sensitivity, while folic acid serves as a methyl donor and cofactor for DNA synthesis and homocysteine metabolism. Used for Type 2 diabetes mellitus, Prevention of B12 deficiency and homocysteine elevation in metformin-treated patients.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}