{"id":"metformin-only","safety":{"commonSideEffects":[{"rate":"20–30","effect":"Gastrointestinal disturbance (nausea, diarrhea, abdominal discomfort)"},{"rate":"3–5","effect":"Metallic taste"},{"rate":"10–30","effect":"Vitamin B12 deficiency (with long-term use)"},{"rate":"<0.1","effect":"Lactic acidosis (rare, in renal impairment)"}]},"_chembl":{"chemblId":"CHEMBL1431","moleculeType":"Small molecule","molecularWeight":"129.17"},"_fixedAt":"2026-03-30T17:32:08.983266","_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin decreases gluconeogenesis in the liver, the primary source of excess glucose in type 2 diabetes, while also enhancing peripheral glucose uptake and utilization. It does not stimulate insulin secretion, making it weight-neutral and safe from hypoglycemia when used as monotherapy. The drug's effects are mediated through AMPK activation and suppression of complex I in the electron transport chain, leading to improved metabolic homeostasis.","oneSentence":"Metformin reduces hepatic glucose production and improves insulin sensitivity by activating AMP-activated protein kinase (AMPK) and inhibiting mitochondrial complex I.","_ai_confidence":"high"},"_scrapedAt":"2026-03-27T23:54:36.369Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Type 2 diabetes mellitus"},{"name":"Prediabetes (prevention of progression to type 2 diabetes)"},{"name":"Polycystic ovary syndrome (PCOS) with insulin resistance"}]},"_fixedFields":["pubmed(185)"],"trialDetails":[{"nctId":"NCT06899061","phase":"PHASE1","title":"Modular Clinical Pharmacology Study to Evaluate the Drug-drug Interaction Potential and Relative Bioavailability of Saruparib","status":"ACTIVE_NOT_RECRUITING","sponsor":"AstraZeneca","startDate":"2025-03-25","conditions":"Advanced Solid Malignancies","enrollment":41},{"nctId":"NCT06907472","phase":"NA","title":"Diabetes Management for Primary Healthcare Centers.","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Abuja","startDate":"2025-09-15","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":106},{"nctId":"NCT04930744","phase":"PHASE2","title":"Safety and Tolerability of Metformin in People With Tuberculosis (TB) and Human Immunodeficiency Virus (HIV)","status":"COMPLETED","sponsor":"University of Massachusetts, Worcester","startDate":"2021-08-26","conditions":"Tuberculosis, Pulmonary Tuberculosis, HIV Coinfection","enrollment":112},{"nctId":"NCT07460336","phase":"NA","title":"Effects of Cofrogliptin on Beta-Cell Function in LADA Patients","status":"NOT_YET_RECRUITING","sponsor":"Second Xiangya Hospital of Central South University","startDate":"2026-03-15","conditions":"Latent Autoimmune Diabetes in Adults (LADA)","enrollment":84},{"nctId":"NCT02365597","phase":"PHASE2","title":"An Efficacy and Safety Study of Erdafitinib (JNJ-42756493) in Participants With Urothelial Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Janssen Research & Development, LLC","startDate":"2015-04-22","conditions":"Urothelial Cancer","enrollment":239},{"nctId":"NCT07469254","phase":"NA","title":"Adding 1% Metformin Gel to Bone Graft in Association With Immediate Dental Implants","status":"COMPLETED","sponsor":"Al-Azhar University","startDate":"2022-11-01","conditions":"Metformin Gel, Bone Graft, Immediate Dental Implants","enrollment":20},{"nctId":"NCT03006172","phase":"PHASE1","title":"To Evaluate the Safety, Tolerability, and Pharmacokinetics of Inavolisib Single Agent in Participants With Solid Tumors and in Combination With Endocrine and Targeted Therapies in Participants With Breast Cancer","status":"ACTIVE_NOT_RECRUITING","sponsor":"Genentech, Inc.","startDate":"2016-12-13","conditions":"Breast Cancer, Solid Tumor","enrollment":200},{"nctId":"NCT02946996","phase":"PHASE2","title":"Study of Pharmacologic Manipulation of AGE (Advanced Glycation Endproducts) Levels in Prostate Cancer Patients Receiving Androgen Deprivation Therapy","status":"TERMINATED","sponsor":"Medical University of South Carolina","startDate":"2016-12-28","conditions":"Prostate Cancer","enrollment":41},{"nctId":"NCT07446400","phase":"PHASE1","title":"A Trial to Examine the Interaction of Repinatrabit With Ethinyl Estradiol/Norethindrone, Metformin,Carbamazepine, Rosuvastatin, and Methotrexate When Administered Together","status":"NOT_YET_RECRUITING","sponsor":"Otsuka Pharmaceutical Development & Commercialization, Inc.","startDate":"2026-03-20","conditions":"Healthy Volunteers","enrollment":48},{"nctId":"NCT03710343","phase":"PHASE2","title":"Metformin for Motor and Cognitive Improvement in Children With Cerebral Palsy: A Feasibility Study","status":"COMPLETED","sponsor":"Holland Bloorview Kids Rehabilitation Hospital","startDate":"2023-11-14","conditions":"Cerebral Palsy","enrollment":3},{"nctId":"NCT04416269","phase":"PHASE4","title":"Oral Anti Diabetic Agents in the Hospital","status":"ACTIVE_NOT_RECRUITING","sponsor":"Emory University","startDate":"2020-08-07","conditions":"Diabetes Mellitus","enrollment":255},{"nctId":"NCT03934021","phase":"","title":"Gut Microbiota in Acute Stroke Patients","status":"COMPLETED","sponsor":"Chinese University of Hong Kong","startDate":"2018-07-01","conditions":"Stroke, Stroke, Acute, Stroke, Ischemic","enrollment":120},{"nctId":"NCT07141342","phase":"NA","title":"Fast In-Bed Tracking (FIT) System Lifestyle Intervention is a Clinical Trial of a Bed Scale Device. Overweight Wheelchair Users Will Participate in a Weight Loss Program, Half Will Receive Bed Scales, and Participants Who Receive the Bed Scales Are Expected to Have Increased Weight Loss.","status":"RECRUITING","sponsor":"Jonathan Pearlman","startDate":"2026-02-16","conditions":"Disability Physical, Wheelchair, Obesity; Overweight","enrollment":92},{"nctId":"NCT07417306","phase":"PHASE3","title":"A Study of HDM1005 in Participants With T2DM Not Controlled With Metformin Alone or in Combination With a Sodium-Glucose Cotransporter 2 (SGLT2) Inhibitor","status":"NOT_YET_RECRUITING","sponsor":"Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.","startDate":"2026-03-27","conditions":"Type 2 Diabetes","enrollment":912},{"nctId":"NCT07412015","phase":"NA","title":"Pilot Bioequivalence Study of Chiglitazar/Metformin Extended-Release Tablets","status":"NOT_YET_RECRUITING","sponsor":"Chipscreen Biosciences, Ltd.","startDate":"2026-05-27","conditions":"T2DM (Type 2 Diabetes Mellitus)","enrollment":24},{"nctId":"NCT07415226","phase":"","title":"Glucose-lowering Drugs as an Adjunct to Insulin Therapy in Chinese Patients With Type 1 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine","startDate":"2026-05-01","conditions":"Type 1 Diabetes Mellitus","enrollment":500},{"nctId":"NCT05743387","phase":"NA","title":"Community-based, eHealth Supported Type 2 Diabetes Care by Lay Village Health Workers in Rural Lesotho","status":"ACTIVE_NOT_RECRUITING","sponsor":"University Hospital, Basel, Switzerland","startDate":"2023-05-13","conditions":"Type 2 Diabetes Mellitus (T2D)","enrollment":252},{"nctId":"NCT07158411","phase":"PHASE1","title":"Evaluate the Effect of Vimseltinib on Organic Cation Transporter 2 (OCT2)","status":"COMPLETED","sponsor":"Deciphera Pharmaceuticals, LLC","startDate":"2025-11-20","conditions":"Healthy Participants","enrollment":22},{"nctId":"NCT07222098","phase":"PHASE1","title":"A Clinical Study of Calderasib (MK-1084) With Rosuvastatin and Metformin in Healthy People (MK-1084-016)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-11-19","conditions":"Healthy","enrollment":16},{"nctId":"NCT07399470","phase":"PHASE1","title":"A Clinical Study in Healthy Adults to See How the Body Processes and How Safe a Tablet That Combines Gemigliptin, Dapagliflozin, and Metformin is, Compared With Taking Zemiglo and Xigduo XR Together While Fasting.","status":"ACTIVE_NOT_RECRUITING","sponsor":"LG Chem","startDate":"2026-01-09","conditions":"Healthy Volunteers, Fasting Conditions","enrollment":58},{"nctId":"NCT07395960","phase":"PHASE1, PHASE2","title":"The Efficacy and Safety of Metformin Intervention in Elderly Overweight or Obesity With Mild Cognitive Impairment","status":"RECRUITING","sponsor":"Fudan University","startDate":"2025-09-01","conditions":"Mild Cognitive Impairment, Overweight or Obesity, Elderly","enrollment":54},{"nctId":"NCT07396844","phase":"PHASE1","title":"The Food Effect on Pharmacokinetics of Fixed Dose Combination of Gemigliptin/Dapagliflozin/Metformin in Healthy Volunteers","status":"NOT_YET_RECRUITING","sponsor":"LG Chem","startDate":"2026-07-01","conditions":"Healthy, Fasting, Fed","enrollment":28},{"nctId":"NCT06961019","phase":"NA","title":"Clinical Study to Assess the Safety, Efficacy and In-Use Tolerability of Herbal-Based Sugar Support Effervescent Tablets in Type-2 Diabetes Mellitus Patients","status":"RECRUITING","sponsor":"NovoBliss Research Pvt Ltd","startDate":"2025-08-25","conditions":"Type2 Diabetes Mellitus","enrollment":14},{"nctId":"NCT07380841","phase":"NA","title":"Metformin vs Inositol vs Diet vs Combination Therapy in PCOS","status":"COMPLETED","sponsor":"Islamabad Medical and Dental College","startDate":"2025-05-21","conditions":"Polycystic Ovary Syndrome, Insulin Resistance, Metabolic Syndrome","enrollment":192},{"nctId":"NCT07244770","phase":"","title":"The Effects of Some Antihyperglycemic Drugs on Cognitive Function and Risk of Depression of Diabetic Patients","status":"RECRUITING","sponsor":"Beni-Suef University","startDate":"2025-01-01","conditions":"MCI","enrollment":300},{"nctId":"NCT07375654","phase":"PHASE1","title":"Combined Use of Cyclosporine and Metformin in Treatment of Psoriasis vs Cyclosporine Alone","status":"COMPLETED","sponsor":"Cairo University","startDate":"2024-12-19","conditions":"Psoriasis","enrollment":32},{"nctId":"NCT07372118","phase":"PHASE1","title":"Bioequivalence Study to Compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg in Fast Condition","status":"COMPLETED","sponsor":"Humanis Saglık Anonim Sirketi","startDate":"2025-09-27","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":32},{"nctId":"NCT07120971","phase":"EARLY_PHASE1","title":"Metformin for Premature Infants With Bronchopulmonary Dysplasia","status":"RECRUITING","sponsor":"Medical College of Wisconsin","startDate":"2025-12-19","conditions":"Bronchopulmonary Dysplasia (BPD)","enrollment":40},{"nctId":"NCT05164263","phase":"PHASE4","title":"Real World Safety & Efficacy Experience of Empagliflozin With or Without Metformin in T2DM Patients - EASE Study","status":"RECRUITING","sponsor":"Getz Pharma","startDate":"2021-04-01","conditions":"Type II Diabetes Mellitus, Efficacy, Self, Safety Issues","enrollment":2000},{"nctId":"NCT05230758","phase":"PHASE3","title":"Effect of Metformin on Behaviour and the Brain in Children Treated for a Brain Tumour","status":"RECRUITING","sponsor":"Donald Mabbott","startDate":"2022-07-01","conditions":"Medulloblastoma, Childhood, Cognitive Impairment","enrollment":140},{"nctId":"NCT02087826","phase":"NA","title":"Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2014-04","conditions":"Genetics, Metabolism, Type 2 Diabetes","enrollment":1017},{"nctId":"NCT07336914","phase":"NA","title":"Effect of Conventional vs Intensive Management on Gestational Diabetes and Maternal Fetal Outcomes","status":"RECRUITING","sponsor":"Khyber Medical University Peshawar","startDate":"2025-10-01","conditions":"Gestational Diabetes","enrollment":60},{"nctId":"NCT05741372","phase":"NA","title":"A Study to Compare How Different Medicines (Rosuvastatin, Digoxin, Metformin, and Furosemide) Are Handled by the Body of Healthy People and People With Liver Cirrhosis","status":"COMPLETED","sponsor":"Boehringer Ingelheim","startDate":"2023-09-07","conditions":"Liver Cirrhosis","enrollment":28},{"nctId":"NCT07333742","phase":"PHASE1","title":"A Clinical Study to See How the Body Handles and How Safe a Combination Tablet of Gemigliptin, Dapagliflozin, and Metformin 50/10/1000mg is Compared to Taking Gemigliptin 50mg Separately With Dapagliflozin/Metformin 10/1000mg in Healthy Adults After a Meal","status":"COMPLETED","sponsor":"LG Chem","startDate":"2025-09-29","conditions":"Fed Conditions, Healthy Volunteer","enrollment":50},{"nctId":"NCT07331389","phase":"PHASE1","title":"A Drug-Drug Interaction Study of HDM1002 and Metformin, Empagliflozin, Midazolam, Valsartan, and Warfarin","status":"RECRUITING","sponsor":"Hangzhou Zhongmei Huadong Pharmaceutical Co., Ltd.","startDate":"2025-09-24","conditions":"Overweight Subject, Healthy Subjects","enrollment":111},{"nctId":"NCT07216131","phase":"PHASE1","title":"A Study to Investigate the Effect of AZD0780 on Metformin Pharmacokinetics in Healthy Adult Volunteers Aged 18 to 55 Years","status":"COMPLETED","sponsor":"AstraZeneca","startDate":"2025-11-10","conditions":"Healthy Participants","enrollment":14},{"nctId":"NCT07323589","phase":"PHASE3","title":"Impact of Myo-Inositol Alone vs Myo-Inositol Plus Metformin on Conception, Adherence, and Tolerability in PCOS","status":"COMPLETED","sponsor":"PAEC general hospital","startDate":"2025-01-01","conditions":"PCOS (Polycystic Ovary Syndrome)","enrollment":120},{"nctId":"NCT07307677","phase":"NA","title":"Melatonin & Metformin on Clinical & Biochemical Parameters in Insulin Resistant PCOS Compared to Metformin","status":"RECRUITING","sponsor":"Mst.Sumyara Khatun","startDate":"2025-03-11","conditions":"PCOS(Insulin Resistant)","enrollment":60},{"nctId":"NCT06445946","phase":"PHASE4","title":"DECIDE: A Comparative Effectiveness Trial of Metformin Versus Insulin for the Treatment of Gestational Diabetes","status":"RECRUITING","sponsor":"Ohio State University","startDate":"2024-08-01","conditions":"Gestational Diabetes Mellitus, Pregnancy, High Risk","enrollment":1572},{"nctId":"NCT07321223","phase":"NA","title":"Comparison of Different Doses of Vitamin D Supplementation on Glycated Haemoglobin and Blood Glucose Parameters With Type II Diabetes Mellitus Having Vitamin d Deficiency","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Lahore","startDate":"2024-08-22","conditions":"Diabetes (DM), Vitamin D Deficiency","enrollment":108},{"nctId":"NCT06415773","phase":"PHASE3","title":"Effects of Berberine Ursodeoxycholate (HTD1801) Versus Dapagliflozin in Patients With Type 2 Diabetes Inadequately Controlled With Metformin","status":"COMPLETED","sponsor":"HighTide Biopharma Pty Ltd","startDate":"2024-06-04","conditions":"T2DM (Type 2 Diabetes Mellitus)","enrollment":367},{"nctId":"NCT07300033","phase":"PHASE1","title":"Bioequivalence Study of Liquid Metformin (100 and 250 mg/mL) vs IR Tablets","status":"NOT_YET_RECRUITING","sponsor":"Aspargo Labs, Inc","startDate":"2026-05-15","conditions":"Healthy Volunteer","enrollment":24},{"nctId":"NCT07300020","phase":"PHASE1","title":"PK and Relative Bioavailability of Novel Liquid Metformin vs Tablets","status":"NOT_YET_RECRUITING","sponsor":"Aspargo Labs, Inc","startDate":"2026-04-15","conditions":"Healthy Volunteer","enrollment":24},{"nctId":"NCT07300059","phase":"PHASE1","title":"Short-Term Glycemic Effects of Liquid Metformin vs Standard Tablets","status":"NOT_YET_RECRUITING","sponsor":"Aspargo Labs, Inc","startDate":"2026-07-15","conditions":"Healthy Volunteers","enrollment":24},{"nctId":"NCT07300046","phase":"PHASE1","title":"Tolerability Study of Liquid Metformin (100 and 250 mg/mL) vs IR Tablets","status":"NOT_YET_RECRUITING","sponsor":"Aspargo Labs, Inc","startDate":"2026-06-15","conditions":"Healthy Volunteers","enrollment":24},{"nctId":"NCT07300007","phase":"PHASE1","title":"PK and Relative Bioavailability of Liquid Metformin vs Tablets in Healthy Adults","status":"NOT_YET_RECRUITING","sponsor":"Aspargo Labs, Inc","startDate":"2026-03-15","conditions":"Healthy Volunteer","enrollment":24},{"nctId":"NCT04691960","phase":"PHASE2","title":"A Pilot Study of Ketogenic Diet and Metformin in Glioblastoma: Feasibility and Metabolic Imaging","status":"ACTIVE_NOT_RECRUITING","sponsor":"Weill Medical College of Cornell University","startDate":"2016-08","conditions":"Glioblastoma","enrollment":18},{"nctId":"NCT05838573","phase":"PHASE3","title":"Metformin Treatment on Cognitive Impairment of Schizophrenia","status":"RECRUITING","sponsor":"Central South University","startDate":"2023-05-08","conditions":"Schizophrenia","enrollment":120},{"nctId":"NCT06983223","phase":"NA","title":"Oral Sucrosomial® Vitamin B12 in the Management of B12 Deficiency Among Metformin-Treated Type 2 Diabetes Patients","status":"COMPLETED","sponsor":"Liaquat University of Medical & Health Sciences","startDate":"2025-08-15","conditions":"Vitamin B 12 Deficiency, Type 2 Diabetes Mellitus (T2DM)","enrollment":50},{"nctId":"NCT06185179","phase":"EARLY_PHASE1","title":"Metformin and Muscle Recovery","status":"RECRUITING","sponsor":"University of Utah","startDate":"2024-09-01","conditions":"Muscle Atrophy or Weakness","enrollment":50},{"nctId":"NCT07266766","phase":"PHASE1","title":"Bioequivalence Study to Compare Empagliflozin / Metformin 25 mg/ 1000 mg Extended-Release Tablet Versus Synjardy XR Tablets 25mg/1000mg","status":"COMPLETED","sponsor":"Humanis Saglık Anonim Sirketi","startDate":"2025-08-05","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":40},{"nctId":"NCT03107884","phase":"EARLY_PHASE1","title":"Role of Metformin on Muscle Health of Older Adults","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Utah","startDate":"2019-08-01","conditions":"Muscle Atrophy, Insulin Resistance","enrollment":64},{"nctId":"NCT05064488","phase":"PHASE1","title":"Drug-Drug Interaction Study of Evobrutinib and Transporter Substrates","status":"COMPLETED","sponsor":"Merck Healthcare KGaA, Darmstadt, Germany, an affiliate of Merck KGaA, Darmstadt, Germany","startDate":"2021-10-04","conditions":"Healthy","enrollment":40},{"nctId":"NCT07266779","phase":"PHASE1","title":"Bioequivalence Study of Test Product (T) of Ertugliflozin/Metformin 7.5 mg/ 1000 mg Film Coated Tablets and Reference Product (R) of Segluromet 7.5 mg/ 1000 mg Film Coated Tablets in Healthy, Adult, Human Subjects Under Fed Condition.","status":"COMPLETED","sponsor":"Humanis Saglık Anonim Sirketi","startDate":"2025-08-22","conditions":"Type 2 Diabetes","enrollment":36},{"nctId":"NCT05515978","phase":"EARLY_PHASE1","title":"Pragmatic Trial of Metformin for Glucose Intolerance or Increased BMI in Prostate Cancer Patients","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2022-10-10","conditions":"Prostate Cancer","enrollment":100},{"nctId":"NCT04220021","phase":"PHASE2","title":"Safety and Therapeutic Potential of the FDA-approved Drug Metformin for C9orf72 ALS/FTD","status":"ACTIVE_NOT_RECRUITING","sponsor":"University of Florida","startDate":"2020-01-10","conditions":"C9orf72 Amyotrophic Lateral Sclerosis (ALS), Frontotemporal Dementia","enrollment":41},{"nctId":"NCT06688123","phase":"PHASE2","title":"Efficacy and Safety of SHR-3167 and Insulin Glargine in Type 2 Diabetes Subjects","status":"ACTIVE_NOT_RECRUITING","sponsor":"Jiangsu HengRui Medicine Co., Ltd.","startDate":"2025-01-08","conditions":"Type 2 Diabetes","enrollment":275},{"nctId":"NCT07241897","phase":"PHASE3","title":"DPP4 Inhibitor Intervention on Post-stroke Cognitive Impairment in Ischemic Stroke Patients With Type 2 Diabetes","status":"NOT_YET_RECRUITING","sponsor":"Second Affiliated Hospital of Soochow University","startDate":"2025-12-15","conditions":"Ischemic Stroke, Diabete Mellitus","enrollment":312},{"nctId":"NCT04945148","phase":"PHASE2","title":"Oxidative Phosphorylation Targeting In Malignant Glioma Using Metformin Plus Radiotherapy Temozolomide","status":"RECRUITING","sponsor":"Hopital Foch","startDate":"2024-05-10","conditions":"Glioblastoma, IDH-wildtype","enrollment":640},{"nctId":"NCT06889454","phase":"","title":"Cardiovascular and Endothelial Markers During OGTT Before and at Six and Twelve Months Post-treatment in Women With PCOS","status":"RECRUITING","sponsor":"Attikon Hospital","startDate":"2024-02-01","conditions":"PCOS, Hyperinsulinism, Hyperandrogenism","enrollment":120},{"nctId":"NCT07098299","phase":"PHASE1","title":"Metformin Combined With Chemotherapy and/or Immunotherapy in Solid Malignancies","status":"RECRUITING","sponsor":"Barbara Ann Karmanos Cancer Institute","startDate":"2025-09-18","conditions":"Advanced Solid Tumor","enrollment":60},{"nctId":"NCT01797523","phase":"PHASE2","title":"A Phase II, Single-Arm Study of RAD001 (Everolimus), Letrozole, and Metformin in Patients With Advanced or Recurrent Endometrial Carcinoma","status":"ACTIVE_NOT_RECRUITING","sponsor":"M.D. Anderson Cancer Center","startDate":"2013-10-07","conditions":"Endometrial Cancer","enrollment":62},{"nctId":"NCT03229057","phase":"PHASE3","title":"Comparing the Effects of Oral Contraceptive Pills Versus Metformin","status":"COMPLETED","sponsor":"Anuja Dokras","startDate":"2018-01-15","conditions":"PCOS","enrollment":240},{"nctId":"NCT07121959","phase":"PHASE1","title":"A Study of Belzutifan (MK-6482) and Metformin in Healthy Adult Participants (MK-6482-039)","status":"COMPLETED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2025-08-18","conditions":"Healthy","enrollment":14},{"nctId":"NCT07215156","phase":"NA","title":"Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis","status":"NOT_YET_RECRUITING","sponsor":"Kafrelsheikh University","startDate":"2025-10-06","conditions":"Stage II, Grade B Periodontitis, Chronic Periodontitis","enrollment":60},{"nctId":"NCT07213895","phase":"PHASE1","title":"Bioequivalence Study to Compare Empagliflozin/Linagliptin/Metformin HCL 25mg/5mg/1000mg Extended-Release Tablets Versus Trijardy® XR Extended Release Film Coated Tablets","status":"COMPLETED","sponsor":"Humanis Saglık Anonim Sirketi","startDate":"2025-05-21","conditions":"Type 2 Diabetes Mellitus (T2DM)","enrollment":14},{"nctId":"NCT06479434","phase":"NA","title":"Serum Biomarker Levels Improvement in Poly Cystic Ovarian Syndrome: Impact of Metformin Compared to Healthy Controls","status":"COMPLETED","sponsor":"Aga Khan University","startDate":"2024-06-24","conditions":"Polycystic Ovary Syndrome, Insulin Resistance","enrollment":110},{"nctId":"NCT07026968","phase":"PHASE3","title":"A Study of Prusogliptin Tablets Combined With Dapagliflozin Tablets and Metformin Hydrochloride Extended Release Tablets in Type 2 Diabetes","status":"ENROLLING_BY_INVITATION","sponsor":"CSPC Ouyi Pharmaceutical Co., Ltd.","startDate":"2025-06-20","conditions":"Type 2 Diabetes","enrollment":815},{"nctId":"NCT06813924","phase":"PHASE1","title":"A Research Study of the Effect of Etavopivat on Other Drugs in Healthy Participants","status":"COMPLETED","sponsor":"Novo Nordisk A/S","startDate":"2025-02-06","conditions":"Healthy Volunteers Sickle Cell Disease, Thalassemia","enrollment":37},{"nctId":"NCT07188740","phase":"PHASE1","title":"Metformin Inhibits DNMT3A Clonal Hematopoiesis in Acute Leukemia","status":"NOT_YET_RECRUITING","sponsor":"Institute of Hematology & Blood Diseases Hospital, China","startDate":"2025-10-30","conditions":"DNMT3A Gene Mutation","enrollment":30},{"nctId":"NCT02710448","phase":"PHASE2","title":"May Metformin be Used in Renal Failure?","status":"COMPLETED","sponsor":"Centre Hospitalier Universitaire, Amiens","startDate":"2012-06","conditions":"Renal Disorder Associated With Type II Diabetes Mellitus","enrollment":82},{"nctId":"NCT07165158","phase":"PHASE4","title":"The Effect of Semaglutide on Bone Health","status":"NOT_YET_RECRUITING","sponsor":"The First Affiliated Hospital of Xiamen University","startDate":"2025-09-15","conditions":"Osteoporosis, Osteoporosis Fracture, T2DM","enrollment":150},{"nctId":"NCT06920056","phase":"PHASE1","title":"A Study of BGM0504 in Overweight or Obese Participants","status":"COMPLETED","sponsor":"BrightGene Bio-Medical Technology Co., Ltd.","startDate":"2025-03-24","conditions":"Overweight or Obese","enrollment":28},{"nctId":"NCT07136987","phase":"PHASE3","title":"A Trial of 2 Disease-Modifying Drugs (Metformin and N-acetylcysteine ) to Promote TB Lung Function Recovery","status":"NOT_YET_RECRUITING","sponsor":"Open Source Pharma Foundation","startDate":"2026-01","conditions":"Tuberculosis","enrollment":1104},{"nctId":"NCT07121088","phase":"PHASE4","title":"Traditional Chinese Medicine Intervention for Ischemic Cerebrovascular Disease and Diabetes Mellitus: An Efficacy Comparative Study","status":"NOT_YET_RECRUITING","sponsor":"Guangzhou University of Traditional Chinese Medicine","startDate":"2025-08-31","conditions":"Ischemic Cerebral Infarction, Diabetes Mellitus","enrollment":3666},{"nctId":"NCT06071442","phase":"PHASE1","title":"Potential Drug Interaction Study Between Vemircopan and Rosuvastatin, Metformin, Levonorgestrel/Ethinyl Estradiol-containing Oral Contraceptives, and Carbamazepine","status":"COMPLETED","sponsor":"Alexion Pharmaceuticals, Inc.","startDate":"2024-01-17","conditions":"Healthy Participants","enrollment":60},{"nctId":"NCT05365451","phase":"EARLY_PHASE1","title":"Pharmacokinetic Drug-Drug Interaction Study to Identify Biomarkers of Kidney Transporters","status":"COMPLETED","sponsor":"Washington State University","startDate":"2022-04-11","conditions":"Interaction, Endogenous Biomarkers","enrollment":16},{"nctId":"NCT07108075","phase":"NA","title":"Acute Portal Pressure Reduction by Metformin and Carvedilol Compared to Carvedilol Alone in Cirrhosis.","status":"RECRUITING","sponsor":"Institute of Liver and Biliary Sciences, India","startDate":"2025-06-14","conditions":"Liver Cirrhosis","enrollment":72},{"nctId":"NCT07088523","phase":"PHASE4","title":"Traditional Chinese Medicine Intervention for Ischemic Cardiovascular Disease Comorbid With Diabetes Mellitus: An Efficacy Comparative Study","status":"NOT_YET_RECRUITING","sponsor":"Guangzhou University of Traditional Chinese Medicine","startDate":"2025-07-31","conditions":"Diabete Mellitus, Ischemic Cardiovascular Disease","enrollment":4205},{"nctId":"NCT05929495","phase":"PHASE2","title":"Phase 2, Open-label, Single-arm Study on the Use of Metformin as Adjunctive Therapy in High-grade Glioma","status":"RECRUITING","sponsor":"University of Milano Bicocca","startDate":"2024-02-12","conditions":"Glioblastoma, IDH-wildtype, Metformin, Malignancies","enrollment":25},{"nctId":"NCT07083401","phase":"PHASE1","title":"A Study to Evaluate the Pharmacokinetics and Safety Between \"BR3006\" and Co-administration of \"BR3006A\", \"BR3006B\", and \"BR3006C\" in Healthy Adult Volunteers (Fed)","status":"RECRUITING","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2025-07-05","conditions":"Diabete Mellitus","enrollment":40},{"nctId":"NCT07083388","phase":"PHASE1","title":"A Study to Evaluate the Pharmacokinetics and Safety Between \"BR3006\" and Co-administration of \"BR3006A\", \"BR3006B\", and \"BR3006C\" in Healthy Adult Volunteers (Fasting)","status":"RECRUITING","sponsor":"Boryung Pharmaceutical Co., Ltd","startDate":"2025-07-03","conditions":"Diabetes Mellitus","enrollment":52},{"nctId":"NCT02879409","phase":"NA","title":"HbA1c Variability in Type II Diabetes","status":"ACTIVE_NOT_RECRUITING","sponsor":"Weill Cornell Medical College in Qatar","startDate":"2016-11","conditions":"Diabetes Mellitus Type 2","enrollment":150},{"nctId":"NCT07072949","phase":"PHASE1","title":"The Impact of Ursodeoxycholic Acid and Probiotics on Metabolic Outcomes in Type 2 Diabetic Patients Taking Metformin","status":"COMPLETED","sponsor":"University of Banja Luka","startDate":"2023-01-03","conditions":"Type 2 Diabetes Mellitus","enrollment":90},{"nctId":"NCT07065591","phase":"EARLY_PHASE1","title":"Anti-Diabetic Drug, Exercise and Healthy Diet for Knee Osteoarthritis With Overweight/Obesity","status":"NOT_YET_RECRUITING","sponsor":"The University of Hong Kong","startDate":"2025-10-01","conditions":"Osteoarthritis (OA) of the Knee","enrollment":100},{"nctId":"NCT06804187","phase":"","title":"Sweet Sensing in Type 2 Diabetes","status":"ENROLLING_BY_INVITATION","sponsor":"University of Nottingham","startDate":"2025-02-01","conditions":"Type 2 Diabetes, Prediabetes","enrollment":505},{"nctId":"NCT06679413","phase":"PHASE1","title":"A Study to Assess Drug-drug Interaction of ZX008 in Healthy Male and Female Study Participants","status":"COMPLETED","sponsor":"UCB BIOSCIENCES, Inc.","startDate":"2024-12-04","conditions":"Healthy Study Participants","enrollment":22},{"nctId":"NCT07044765","phase":"PHASE1","title":"A Study to Evaluate the Safety and Pharmacokinetics of Dapagliflozin, Linagliptin, and Metformin in Healthy Adults: Fed State Study","status":"NOT_YET_RECRUITING","sponsor":"AJU Pharm Co., Ltd.","startDate":"2025-08","conditions":"Type2 Diabetes Mellitus","enrollment":32},{"nctId":"NCT04972396","phase":"PHASE1","title":"Pemvidutide (ALT-801) DDI Study in Healthy Volunteers","status":"COMPLETED","sponsor":"Altimmune, Inc.","startDate":"2021-09-15","conditions":"NASH - Nonalcoholic Steatohepatitis","enrollment":40},{"nctId":"NCT07034781","phase":"PHASE1","title":"A Study to Evaluate the Safety and Pharmacokinetics of Dapagliflozin, Linagliptin, and Metformin in Healthy Adults","status":"NOT_YET_RECRUITING","sponsor":"AJU Pharm Co., Ltd.","startDate":"2025-08","conditions":"Type2 Diabetes Mellitus","enrollment":50},{"nctId":"NCT06723691","phase":"PHASE1","title":"Influence of HRS9531 on Gastric Emptying and Pharmacokinetics of Metformin, Atorvastatin, Warfarin, and Digoxin in Healthy Subjects","status":"COMPLETED","sponsor":"Fujian Shengdi Pharmaceutical Co., Ltd.","startDate":"2024-12-18","conditions":"Type 2 Diabetes","enrollment":57},{"nctId":"NCT03675893","phase":"PHASE2","title":"RESOLVE: Abemaciclib + Letrozole +/- Metformin, Zotatifin, or Gedatolisib in Endometrial or Low-Grade Serous Ovarian Cancer","status":"RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2018-12-24","conditions":"Endometrial Cancer, Ovarian Cancer","enrollment":180},{"nctId":"NCT03686657","phase":"PHASE1, PHASE2","title":"Evaluation of Superiority of Valsartan+Celecoxib+Metformin Over Metformin Alone in Type 2 Diabetes Patients","status":"NOT_YET_RECRUITING","sponsor":"ARKAY Therapeutics","startDate":"2025-10-10","conditions":"Type 2 Diabetes, High Blood Pressure, Arthritis","enrollment":115},{"nctId":"NCT06359015","phase":"PHASE4","title":"Metformin and Esomeprazole in Preterm Pre-eclampsia","status":"TERMINATED","sponsor":"Christiana Care Health Services","startDate":"2021-02-11","conditions":"Preeclampsia Severe, Pre-Eclampsia, Preeclampsia","enrollment":4},{"nctId":"NCT04008186","phase":"PHASE1","title":"A Clinical Drug-Drug Interaction (DDI) Study With Omaveloxolone","status":"COMPLETED","sponsor":"Biogen","startDate":"2019-06-14","conditions":"Healthy Adult Subjects","enrollment":61},{"nctId":"NCT01135433","phase":"PHASE3","title":"A Study to Assess the Efficacy and Safety of ASP1941 in Combination With Metformin in Type 2 Diabetic Patients","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"2010-05-15","conditions":"Type 2 Diabetes Mellitus","enrollment":168},{"nctId":"NCT04090580","phase":"PHASE3","title":"Impact on Glycemic Variability in Newly Onset T2DM Patients Initiating Dapagliflozin Plus Metformin Versus Metformin Alone","status":"COMPLETED","sponsor":"Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran","startDate":"2019-10-27","conditions":"Type 2 Diabetes","enrollment":88},{"nctId":"NCT01117584","phase":"PHASE2","title":"A Study to Evaluate the Effect of ASP1941 in Combination With Metformin in Adult Patients With Type 2 Diabetes Mellitus","status":"COMPLETED","sponsor":"Astellas Pharma Inc","startDate":"2010-04-06","conditions":"Type 2 Diabetes Mellitus","enrollment":343},{"nctId":"NCT06335134","phase":"PHASE1","title":"A Drug-Drug Interaction Study Between XW003 and Metformin, Warfarin, Rosuvastatin or Digoxin","status":"COMPLETED","sponsor":"Hangzhou Sciwind Biosciences Co., Ltd.","startDate":"2023-07-14","conditions":"Healthy Volunteers","enrollment":57},{"nctId":"NCT01762046","phase":"PHASE1","title":"Study to Understand the Genetics of the Acute Response to Metformin and Glipizide in Humans","status":"ACTIVE_NOT_RECRUITING","sponsor":"Massachusetts General Hospital","startDate":"2008-01","conditions":"Diabetes Mellitus, Type 2","enrollment":1033}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":185,"recentPublications":[{"date":"2026 Mar 23","pmid":"41881108","title":"Adjunctive melatonin and sildenafil, enhances antioxidant defense in metformin-treated polycystic ovary syndrome patients: A randomized study.","journal":"Journal of gynecology obstetrics and human reproduction"},{"date":"2026 Mar","pmid":"41767833","title":"The Effect of Carnosine Supplementation on Depressive Symptoms and Health-Related Quality of Life in Individuals With Prediabetes and Well-Controlled Type 2 Diabetes: A Randomized Controlled Trial.","journal":"Food science & nutrition"},{"date":"2026 Feb 3","pmid":"41634377","title":"Obesity, metformin prescription and risk of advanced prostate cancer in non-diabetic men.","journal":"BJC reports"},{"date":"2025 Dec","pmid":"41359669","title":"Impact of combined hormonal contraceptives and metformin on metabolic syndrome in women with hyperandrogenic polycystic ovary syndrome and obesity: The COMET-PCOS randomized clinical trial.","journal":"PLoS medicine"},{"date":"2025 Jul","pmid":"40677108","title":"Serum Proteome Profiling of Diabetic Patients Treated With DPP4 and SGLT2 Inhibitors Shows Improved Cognitive and Cardiovascular Functions.","journal":"Proteomics"}],"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":[],"phase":"marketed","status":"active","brandName":"Metformin only","genericName":"Metformin only","companyName":"Sheba Medical Center","companyId":"sheba-medical-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Metformin reduces hepatic glucose production and improves insulin sensitivity, lowering blood glucose levels in type 2 diabetes. Used for Type 2 diabetes mellitus, Prediabetes (prevention of progression to type 2 diabetes), Polycystic ovary syndrome (PCOS).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}