{"id":"metformin-clomiphene","safety":{"commonSideEffects":[{"rate":"20-30","effect":"Gastrointestinal disturbance (metformin)"},{"rate":"10-20","effect":"Hot flushes (clomiphene)"},{"rate":"1-2","effect":"Ovarian hyperstimulation syndrome (clomiphene)"},{"rate":"1-5","effect":"Visual disturbances (clomiphene)"},{"rate":"5-10","effect":"Headache"},{"rate":"10-15","effect":"Nausea"}]},"_chembl":{"chemblId":"CHEMBL3185958","moleculeType":"Small molecule","molecularWeight":"598.09"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"This combination targets polycystic ovary syndrome (PCOS) and infertility by addressing both the metabolic dysfunction (via metformin's effects on insulin resistance) and the reproductive dysfunction (via clomiphene's ovulatory stimulation). Metformin reduces hyperinsulinemia and androgen levels, while clomiphene acts as a selective estrogen receptor modulator to promote follicle-stimulating hormone (FSH) secretion and ovulation.","oneSentence":"Metformin improves insulin sensitivity and reduces hepatic glucose production, while clomiphene stimulates ovulation by blocking estrogen feedback on the hypothalamus and pituitary.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-27T23:54:34.972Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Polycystic ovary syndrome (PCOS) with anovulation and infertility"},{"name":"Clomiphene-resistant PCOS"}]},"trialDetails":[{"nctId":"NCT02523898","phase":"PHASE2","title":"Metformine and CC Compared With Placebo and CC for Induction Ovulation in PCOS Patients With Insulin Resistant","status":"TERMINATED","sponsor":"Semnan University of Medical Sciences","startDate":"2015-11","conditions":"Polycystic Ovary Syndrome, Hyperandrogenism","enrollment":388},{"nctId":"NCT03135301","phase":"PHASE3","title":"Letrozole in Clomiphene Resistant Infertile Women With Polycystic Ovarian Syndrome","status":"UNKNOWN","sponsor":"Assiut University","startDate":"2017-06-20","conditions":"Infertility, Female","enrollment":80},{"nctId":"NCT05362799","phase":"PHASE4","title":"Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles","status":"UNKNOWN","sponsor":"Menoufia University","startDate":"2022-06-01","conditions":"Infertility, Female","enrollment":176},{"nctId":"NCT03566225","phase":"EARLY_PHASE1","title":"Pioglitazone Versus Metformin as First Treatment in Infertile Women With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-01-30","conditions":"Pioglitazone","enrollment":400},{"nctId":"NCT04170439","phase":"NA","title":"Added Value of N Acetyle Cysteine to Clomiphene Citrate in 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Deficiency","enrollment":120},{"nctId":"NCT03681197","phase":"EARLY_PHASE1","title":"Metformin Use and Clinical Pregnancy Rate in Women With Unexplained Infertility","status":"UNKNOWN","sponsor":"Elham Raafat","startDate":"2018-06-15","conditions":"Infertility","enrollment":170},{"nctId":"NCT03108963","phase":"PHASE2","title":"L-carnitine and Metformin in Obese PCOS Women.","status":"COMPLETED","sponsor":"Zagazig University","startDate":"2017-01","conditions":"PCOS","enrollment":280},{"nctId":"NCT02304536","phase":"PHASE3","title":"Comparison Between Laparoscopic Ovarian Diathermy and Urinary Purified FSH in Women With Clomiphene Citrate Resistant Polycystic Ovarian Syndrome.","status":"UNKNOWN","sponsor":"Cairo University","startDate":"2014-11","conditions":"Infertility","enrollment":210},{"nctId":"NCT01909141","phase":"EARLY_PHASE1","title":"Ovulation Induction in Women With Clomiphene Citrate Resistant PCOS","status":"COMPLETED","sponsor":"Cairo 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for Ovulation Induction in Anovulatory Infertile Patients With PCOS","status":"UNKNOWN","sponsor":"University Magna Graecia","startDate":"2007-01","conditions":"Anovulatory Infertility Related to Polycystic Ovary Syndrome","enrollment":552},{"nctId":"NCT00502229","phase":"PHASE4","title":"Therapy for Infertile PCOS Patients Ovulating Under Clomiphene Citrate or Metformin","status":"WITHDRAWN","sponsor":"University Magna Graecia","startDate":"2010-01","conditions":"Polycystic Ovary Syndrome, Infertility","enrollment":""},{"nctId":"NCT01784380","phase":"","title":"The Potential Biochemical Diagnosis Criteria and Therapeutic Effect Indexes: Sex Hormone Binding Globulin Levels and Free Androgen Index in Blood of Patients With Polycystic Ovary Syndrome","status":"COMPLETED","sponsor":"Zhongshan Bo Ai Hospital","startDate":"2006-10","conditions":"The Investigators Collected 534 PCOS Patients as the Case Group,and 580 Infertile Women With Normal Ovulatory Cycle of the Control Group;, At the 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