{"id":"metformin-clomid-hcg","safety":{"commonSideEffects":[{"rate":"10–30%","effect":"Gastrointestinal disturbance (metformin)"},{"rate":"10–20%","effect":"Hot flashes (clomiphene)"},{"rate":"1–10%","effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":"5–15%","effect":"Headache"},{"rate":"5–15%","effect":"Abdominal bloating or discomfort"}]},"_chembl":{"chemblId":"CHEMBL1431","moleculeType":"Small molecule","molecularWeight":"129.17"},"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin reduces insulin resistance and may improve ovulatory function in polycystic ovary syndrome (PCOS). Clomiphene citrate acts as a selective estrogen receptor modulator to promote follicle-stimulating hormone (FSH) secretion and induce ovulation. hCG mimics luteinizing hormone to trigger final oocyte maturation and supports corpus luteum function post-ovulation.","oneSentence":"This combination uses metformin to improve insulin sensitivity, clomiphene citrate to stimulate ovulation, and human chorionic gonadotropin (hCG) to support the luteal phase and early pregnancy in assisted reproductive technology.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T00:41:22.675Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility associated with anovulation or oligo-ovulation, particularly in PCOS"},{"name":"Assisted reproductive technology (ART) ovarian stimulation protocols"}]},"trialDetails":[{"nctId":"NCT05362799","phase":"PHASE4","title":"Different Induction Protocols in PCOS After Clomiphene Citrate Failed Pregnancy in Non-IVF Cycles","status":"UNKNOWN","sponsor":"Menoufia University","startDate":"2022-06-01","conditions":"Infertility, Female","enrollment":176},{"nctId":"NCT01529177","phase":"PHASE4","title":"Metformin for the Treatment of Unexplained Oligozspermia","status":"UNKNOWN","sponsor":"The Egyptian IVF-ET Center","startDate":"2012-02","conditions":"Infertility","enrollment":600},{"nctId":"NCT01638988","phase":"PHASE3","title":"Clomifene Citrate Versus Metformin in First-line Treatment of Infertility in Patients With Polycystic Ovary Syndrome and a Resistance to Insulin","status":"WITHDRAWN","sponsor":"Clinique Ovo","startDate":"2013-09","conditions":"Polycystic Ovary Syndrome, Insulin Resistance","enrollment":""}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Glucophage / clomiphene citrate / choriomon"],"phase":"marketed","status":"active","brandName":"Metformin / clomid / hCG","genericName":"Metformin / clomid / hCG","companyName":"The Egyptian IVF-ET Center","companyId":"the-egyptian-ivf-et-center","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses metformin to improve insulin sensitivity, clomiphene citrate to stimulate ovulation, and human chorionic gonadotropin (hCG) to support luteal phase function and early pregnancy in assisted reproductive therapy. Used for Infertility associated with anovulation or oligo-ovulation, particularly in PCOS, Assisted reproductive technology (ART) / in vitro fertilization (IVF) support.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}