{"id":"metformin-and-fshr","safety":{"commonSideEffects":[{"rate":null,"effect":"Gastrointestinal disturbance (metformin)"},{"rate":null,"effect":"Ovarian hyperstimulation syndrome (OHSS)"},{"rate":null,"effect":"Headache"},{"rate":null,"effect":"Injection site reaction (FSHr)"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Metformin reduces hepatic glucose production and improves peripheral insulin sensitivity, which can benefit women with insulin resistance and polycystic ovary syndrome (PCOS). FSHr agonism directly stimulates follicle-stimulating hormone receptors on ovarian granulosa cells to promote follicular growth and oocyte maturation. The combination addresses both metabolic dysfunction and ovulatory dysfunction in infertile women.","oneSentence":"This combination uses metformin to improve insulin sensitivity and metabolic parameters while FSHr (follicle-stimulating hormone receptor) agonism promotes follicular development for fertility enhancement.","_ai_confidence":"low"},"_scrapedAt":"2026-03-27T23:54:39.384Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Infertility in women with PCOS or insulin resistance"}]},"trialDetails":[{"nctId":"NCT00378729","phase":"PHASE4","title":"Surgical Ovarian Drilling Versus Hormonal Treatment for Infertility Associated to PolyCystic Ovaries Syndrome (PCOS)","status":"UNKNOWN","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2006-10","conditions":"Polycystic Ovary Syndrome","enrollment":252}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":0,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["treatment for infertility"],"phase":"marketed","status":"active","brandName":"Metformin and FSHr","genericName":"Metformin and FSHr","companyName":"Assistance Publique - Hôpitaux de Paris","companyId":"assistance-publique-h-pitaux-de-paris","modality":"Small molecule","firstApprovalDate":"","aiSummary":"This combination uses metformin to improve insulin sensitivity and metabolic parameters while FSH receptor stimulation promotes follicle development for fertility enhancement. Used for Polycystic ovary syndrome (PCOS) with infertility, Female infertility with metabolic dysfunction.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}