{"id":"metergoline","rwe":[{"pmid":"40744614","year":"2025","title":"High-content phenotypic screening reveals natural product bioactives that disrupt mosquito activity, development and serotonergic signaling.","finding":"","journal":"Pesticide biochemistry and physiology","studyType":"Clinical Study"},{"pmid":"39737099","year":"2024","title":"Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.","finding":"","journal":"Journal of inflammation research","studyType":"Clinical Study"},{"pmid":"39396859","year":"2024","title":"Prevalence of pseudopregnancy in bitch attending a veterinary teaching hospital in Spain.","finding":"","journal":"Reproduction in domestic animals = Zuchthygiene","studyType":"Clinical Study"},{"pmid":"38578824","year":"2024","title":"A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor.","finding":"","journal":"Cell reports","studyType":"Clinical Study"},{"pmid":"38030022","year":"2024","title":"Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.","finding":"","journal":"Journal of ethnopharmacology","studyType":"Clinical Study"}],"tags":[{"label":"metergoline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"5-hydroxytryptamine receptor 2C","category":"target"},{"label":"HTR2C","category":"gene"},{"label":"HTR1D","category":"gene"},{"label":"HTR2B","category":"gene"},{"label":"G02CB05","category":"atc"},{"label":"Active","category":"status"},{"label":"Dopamine Agents","category":"pharmacology"},{"label":"Dopamine Agonists","category":"pharmacology"},{"label":"Neurotransmitter Agents","category":"pharmacology"},{"label":"Serotonin Agents","category":"pharmacology"},{"label":"Serotonin Antagonists","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"liserdol","offLabel":[],"synonyms":["metergoline","liserdol","metergolin","methergoline","FI-6337"],"timeline":[],"approvals":[],"brandName":"Liserdol","ecosystem":[],"mechanism":{"target":"5-hydroxytryptamine receptor 1E, 5-hydroxytryptamine receptor 5A, 5-hydroxytryptamine receptor 6","targets":[{"gene":"HTR2C","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2C","protein":"5-hydroxytryptamine receptor 2C"},{"gene":"HTR1D","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1D","protein":"5-hydroxytryptamine receptor 1D"},{"gene":"HTR2B","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2B","protein":"5-hydroxytryptamine receptor 2B"},{"gene":"HTR1A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 1A","protein":"5-hydroxytryptamine receptor 1A"},{"gene":"HTR2A","source":"DrugCentral","target":"5-hydroxytryptamine receptor 2A","protein":"5-hydroxytryptamine receptor 2A"},{"gene":"DRD3","source":"DrugCentral","target":"D(3) dopamine receptor","protein":"D(3) dopamine receptor"},{"gene":"HTR7","source":"DrugCentral","target":"5-hydroxytryptamine receptor 7","protein":"5-hydroxytryptamine receptor 7"},{"gene":"ADRA2B","source":"DrugCentral","target":"Alpha-2B adrenergic receptor","protein":"Alpha-2B adrenergic receptor"},{"gene":"DRD2","source":"DrugCentral","target":"D(2) dopamine receptor","protein":"D(2) dopamine receptor"},{"gene":"ADRA2A","source":"DrugCentral","target":"Alpha-2A adrenergic receptor","protein":"Alpha-2A adrenergic receptor"}],"modality":"Small Molecule","drugClass":"metergoline","explanation":"Imagine your brain is like a busy city with many different signals being sent and received. Serotonin is a chemical messenger that helps regulate mood, appetite, and other functions. Liserdol helps calm down the serotonin signals by blocking the 5-hydroxytryptamine receptor 2C, which can help reduce symptoms of certain conditions.","oneSentence":"Liserdol works by binding to serotonin receptors in the brain, specifically the 5-hydroxytryptamine receptor 2C.","technicalDetail":"Liserdol acts as a selective 5-HT2C receptor antagonist, competing with serotonin for binding sites on the receptor and reducing the downstream effects of serotonin signaling."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Metergoline","title":"Metergoline","extract":"Metergoline, also known as methergoline and sold under the brand names Contralac (veterinary) and Liserdol (clinical), is a monoaminergic medication of the ergoline group which is used as a prolactin inhibitor in the treatment of hyperprolactinemia and to suppress lactation."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1723","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METERGOLINE","fields":["publications"],"source":"PubMed/NCBI"},{"id":3,"url":"https://en.wikipedia.org/wiki/Metergoline","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T15:02:00.127651","biosimilars":[],"competitors":[{"drugName":"bromocriptine","drugSlug":"bromocriptine","fdaApproval":"1978-06-28","patentExpiry":"Jun 7, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cabergoline","drugSlug":"cabergoline","fdaApproval":"1996-12-23","genericCount":9,"patentStatus":"Off-patent — generic available","relationship":"same-class"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"metergoline","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"bromocriptine","brandName":"bromocriptine","genericName":"bromocriptine","approvalYear":"1978","relationship":"same-class"},{"drugId":"cabergoline","brandName":"cabergoline","genericName":"cabergoline","approvalYear":"1996","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167294","NDDF":"006336","UNII":"1501393LY5","CHEBI":"CHEBI:64216","INN_ID":"2378","RXNORM":"6834","UMLSCUI":"C0025641","ChEMBL_ID":"CHEMBL1276418","KEGG_DRUG":"D07218","DRUGBANK_ID":"DB13520","PUBCHEM_CID":"28693","IUPHAR_LIGAND_ID":"133","MESH_DESCRIPTOR_UI":"D008711"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","halfLife":"0.93 hours","clearance":"9.6 mL/min/kg","bioavailability":"23%","volumeOfDistribution":"0.57 L/kg"},"publicationCount":933,"therapeuticAreas":["Other"],"atcClassification":{"source":"DrugCentral","atcCode":"G02CB05","allCodes":["G02CB05"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Sep","pmid":"40744614","title":"High-content phenotypic screening reveals natural product bioactives that disrupt mosquito activity, development and serotonergic signaling.","journal":"Pesticide biochemistry and physiology"},{"date":"2024","pmid":"39737099","title":"Investigates the Role of PANoptosis in Idiopathic Pulmonary Fibrosis and Potential Therapeutic Targets.","journal":"Journal of inflammation research"},{"date":"2024 Oct","pmid":"39396859","title":"Prevalence of pseudopregnancy in bitch attending a veterinary teaching hospital in Spain.","journal":"Reproduction in domestic animals = Zuchthygiene"},{"date":"2024 Apr 23","pmid":"38578824","title":"A platform for predicting mechanism of action based on bacterial transcriptional responses identifies an unusual DNA gyrase inhibitor.","journal":"Cell reports"},{"date":"2024 Mar 1","pmid":"38030022","title":"Evaluation of the anti-nociceptive profile of essential oil from Melissa officinalis L. (lemon balm) in acute and chronic pain models.","journal":"Journal of ethnopharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Liserdol, also known as METERGOLINE, is a small molecule drug that targets the 5-hydroxytryptamine receptor 2C. It belongs to the metergoline class and works by interacting with serotonin receptors in the brain. However, due to the lack of FDA approval information, its approved indications and commercial status are unknown. Liserdol has a short half-life of 0.93 hours and limited bioavailability of 23%. Further research is needed to determine its safety and efficacy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}