{"id":"metampicillin","rwe":[{"pmid":"33087772","year":"2020","title":"Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde.","finding":"","journal":"Scientific reports","studyType":"Clinical Study"},{"pmid":"15567297","year":"2005","title":"Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.","finding":"","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V","studyType":"Clinical Study"},{"pmid":"12586400","year":"2003","title":"Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity.","finding":"","journal":"FEMS microbiology letters","studyType":"Clinical Study"},{"pmid":"7780585","year":"1995","title":"Simultaneous determination of ampicillin and metampicillin in biological fluids using high-performance liquid chromatography with column switching.","finding":"","journal":"Journal of chromatography. B, Biomedical applications","studyType":"Clinical Study"},{"pmid":"4046753","year":"1985","title":"Biliary elimination of beta-lactam antibiotics by the isolated perfused rabbit liver.","finding":"","journal":"Liver","studyType":"Clinical Study"}],"tags":[{"label":"metampicillin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"J01CA14","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"fedacilina","offLabel":[],"synonyms":["metampicillin","methylenampicillin","fedacilina","pravacilin"],"timeline":[],"approvals":[],"brandName":"Fedacilina","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"metampicillin","explanation":"Imagine the bacterial cell wall like a brick wall. Fedacilina blocks the enzyme that helps hold the bricks together, causing the wall to weaken and eventually collapse, ultimately killing the bacterial cell.","oneSentence":"Fedacilina works by inhibiting the bacterial enzyme transpeptidase, which is essential for bacterial cell wall synthesis.","technicalDetail":"Fedacilina exerts its antibacterial effect by competitively inhibiting the action of transpeptidase, a key enzyme involved in the cross-linking of peptidoglycan chains in the bacterial cell wall, thereby disrupting cell wall synthesis and leading to cell lysis."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1718","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=METAMPICILLIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:36:34.487906","biosimilars":[],"competitors":[{"drugName":"ampicillin","drugSlug":"ampicillin","fdaApproval":"1965-12-17","genericCount":18,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"carbenicillin","drugSlug":"carbenicillin","fdaApproval":"","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"amoxicillin","drugSlug":"amoxicillin","fdaApproval":"1974-12-09","patentExpiry":"May 7, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"carindacillin","drugSlug":"carindacillin","fdaApproval":"1972-10-26","relationship":"same-class"},{"drugName":"bacampicillin","drugSlug":"bacampicillin","fdaApproval":"1980-12-22","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"azlocillin","drugSlug":"azlocillin","fdaApproval":"1982-09-03","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mezlocillin","drugSlug":"mezlocillin","fdaApproval":"1981-09-21","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"mecillinam","drugSlug":"mecillinam","fdaApproval":"","relationship":"same-class"},{"drugName":"piperacillin","drugSlug":"piperacillin","fdaApproval":"1981-12-29","genericCount":2,"patentStatus":"Off-patent — generic 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available","relationship":"same-class"}],"genericName":"metampicillin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"ampicillin","brandName":"ampicillin","genericName":"ampicillin","approvalYear":"1965","relationship":"same-class"},{"drugId":"carbenicillin","brandName":"carbenicillin","genericName":"carbenicillin","approvalYear":"","relationship":"same-class"},{"drugId":"amoxicillin","brandName":"amoxicillin","genericName":"amoxicillin","approvalYear":"1974","relationship":"same-class"},{"drugId":"carindacillin","brandName":"carindacillin","genericName":"carindacillin","approvalYear":"1972","relationship":"same-class"},{"drugId":"bacampicillin","brandName":"bacampicillin","genericName":"bacampicillin","approvalYear":"1980","relationship":"same-class"},{"drugId":"azlocillin","brandName":"azlocillin","genericName":"azlocillin","approvalYear":"1982","relationship":"same-class"},{"drugId":"mezlocillin","brandName":"mezlocillin","genericName":"mezlocillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"mecillinam","brandName":"mecillinam","genericName":"mecillinam","approvalYear":"","relationship":"same-class"},{"drugId":"piperacillin","brandName":"piperacillin","genericName":"piperacillin","approvalYear":"1981","relationship":"same-class"},{"drugId":"ticarcillin","brandName":"ticarcillin","genericName":"ticarcillin","approvalYear":"1976","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"005845","UNII":"G0H6U7VSTK","CHEBI":"CHEBI:52060","INN_ID":"2570","RXNORM":"29629","UMLSCUI":"C0066082","ChEMBL_ID":"CHEMBL1908324","KEGG_DRUG":"D07234","DRUGBANK_ID":"DB13836","PUBCHEM_CID":"6713928","IUPHAR_LIGAND_ID":"12274"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":31,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01CA14","allCodes":["J01CA14"]},"biosimilarFilings":[],"recentPublications":[{"date":"2020 Oct 21","pmid":"33087772","title":"Metampicillin is a cyclic aminal produced by reaction of ampicillin with formaldehyde.","journal":"Scientific reports"},{"date":"2005 Jan","pmid":"15567297","title":"Interaction of 31 beta-lactam antibiotics with the H+/peptide symporter PEPT2: analysis of affinity constants and comparison with PEPT1.","journal":"European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V"},{"date":"2003 Jan 28","pmid":"12586400","title":"Deacetoxycephalosporin C synthase isozymes exhibit diverse catalytic activity and substrate specificity.","journal":"FEMS microbiology letters"},{"date":"1995 Feb 17","pmid":"7780585","title":"Simultaneous determination of ampicillin and metampicillin in biological fluids using high-performance liquid chromatography with column switching.","journal":"Journal of chromatography. B, Biomedical applications"},{"date":"1985 Jun","pmid":"4046753","title":"Biliary elimination of beta-lactam antibiotics by the isolated perfused rabbit liver.","journal":"Liver"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Fedacilina (Metampicillin) is a small molecule antibiotic in the penicillin class. It is used to treat various bacterial infections, although its specific indications are not well-documented. The commercial status of Fedacilina is unclear, and it may be available as a generic or patented product. As a penicillin antibiotic, Fedacilina works by inhibiting bacterial cell wall synthesis, ultimately leading to bacterial cell death. However, more information is needed to provide a comprehensive summary.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}