{"id":"metacycline","rwe":[],"tags":[{"label":"metacycline","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"DNA repair protein RAD52 homolog","category":"target"},{"label":"RAD52","category":"gene"},{"label":"SIRT5","category":"gene"},{"label":"J01AA05","category":"atc"},{"label":"Active","category":"status"},{"label":"Bacterial enteritis","category":"indication"},{"label":"Anti-Bacterial Agents","category":"pharmacology"},{"label":"Anti-Infective Agents","category":"pharmacology"}],"phase":"marketed","safety":{"contraindications":["Breastfeeding (mother)","Disease of liver","Kidney disease","Pregnancy, function","Pseudomembranous enterocolitis"]},"trials":[],"aliases":[],"patents":[],"pricing":[],"_sources":{"trials":{"url":"https://clinicaltrials.gov/search?intr=metacycline","method":"api_direct","source":"ClinicalTrials.gov","rawText":"","confidence":1,"sourceType":"ctgov","retrievedAt":"2026-04-20T01:57:05.931346+00:00"},"regulatory.ca":{"url":"","method":"api_direct","source":"Health Canada DPD","rawText":"","confidence":1,"sourceType":"health_canada_dpd","retrievedAt":"2026-04-20T01:57:17.136049+00:00"},"publicationCount":{"url":"https://pubmed.ncbi.nlm.nih.gov/?term=metacycline","method":"api_direct","source":"PubMed/NCBI","rawText":"","confidence":1,"sourceType":"pubmed","retrievedAt":"2026-04-20T01:57:17.817963+00:00"},"crossReferences.chemblId":{"url":"https://www.ebi.ac.uk/chembl/compound_report_card/CHEMBL249837/","method":"api_direct","source":"ChEMBL (EMBL-EBI)","rawText":"","confidence":1,"sourceType":"chembl","retrievedAt":"2026-04-20T01:57:18.309961+00:00"}},"allNames":"rondomycin","offLabel":[],"synonyms":["rondomycin","methacycline hydrochloride","methacycline","metacycline","methacycline HCl"],"timeline":[],"approvals":[{"date":"","orphan":false,"company":"","regulator":"FDA"}],"brandName":"Rondomycin","ecosystem":[{"indication":"Bacterial enteritis","otherDrugs":[],"globalPrevalence":null}],"mechanism":{"target":"DNA repair protein RAD52 homolog","novelty":"First-in-class","targets":[{"gene":"RAD52","source":"DrugCentral","target":"DNA repair protein RAD52 homolog","protein":"DNA repair protein RAD52 homolog"},{"gene":"SIRT5","source":"DrugCentral","target":"NAD-dependent protein deacylase sirtuin-5, mitochondrial","protein":"NAD-dependent protein deacylase sirtuin-5, mitochondrial"}],"modality":"Small Molecule","drugClass":"metacycline","explanation":"","oneSentence":"","technicalDetail":"Rondomycin specifically binds to the RAD52 homolog protein, inhibiting its ability to facilitate homologous recombination and other DNA repair processes, ultimately leading to the death of bacterial cells."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1727","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=metacycline","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=metacycline","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:36:27.664485","_validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:57:20.443428+00:00","fieldsConflicting":1,"overallConfidence":0.8},"biosimilars":[],"competitors":[{"drugName":"demeclocycline","drugSlug":"demeclocycline","fdaApproval":"1960-01-14","genericCount":4,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"doxycycline","drugSlug":"doxycycline","fdaApproval":"1967-12-05","patentExpiry":"Dec 19, 2027","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"chlortetracycline","drugSlug":"chlortetracycline","fdaApproval":"1950-01-23","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"oxytetracycline","drugSlug":"oxytetracycline","fdaApproval":"1964-09-08","patentStatus":"Unknown","relationship":"same-class"},{"drugName":"tetracycline","drugSlug":"tetracycline","fdaApproval":"1953-11-19","genericCount":34,"patentStatus":"Off-patent — generic available","relationship":"same-class"},{"drugName":"minocycline","drugSlug":"minocycline","fdaApproval":"1971-06-30","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tigecycline","drugSlug":"tigecycline","fdaApproval":"2005-06-15","patentExpiry":"Oct 8, 2030","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"sarecycline","drugSlug":"sarecycline","fdaApproval":"2018-10-01","patentExpiry":"Jan 3, 2032","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"omadacycline","drugSlug":"omadacycline","fdaApproval":"2018-10-02","patentExpiry":"Sep 23, 2030","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"metacycline","indications":{"approved":[{"name":"Bacterial enteritis","source":"DrugCentral","snomedId":75375008,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"demeclocycline","brandName":"demeclocycline","genericName":"demeclocycline","approvalYear":"1960","relationship":"same-class"},{"drugId":"doxycycline","brandName":"doxycycline","genericName":"doxycycline","approvalYear":"1967","relationship":"same-class"},{"drugId":"chlortetracycline","brandName":"chlortetracycline","genericName":"chlortetracycline","approvalYear":"1950","relationship":"same-class"},{"drugId":"oxytetracycline","brandName":"oxytetracycline","genericName":"oxytetracycline","approvalYear":"1964","relationship":"same-class"},{"drugId":"tetracycline","brandName":"tetracycline","genericName":"tetracycline","approvalYear":"1953","relationship":"same-class"},{"drugId":"minocycline","brandName":"minocycline","genericName":"minocycline","approvalYear":"1971","relationship":"same-class"},{"drugId":"tigecycline","brandName":"tigecycline","genericName":"tigecycline","approvalYear":"2005","relationship":"same-class"},{"drugId":"sarecycline","brandName":"sarecycline","genericName":"sarecycline","approvalYear":"2018","relationship":"same-class"},{"drugId":"omadacycline","brandName":"omadacycline","genericName":"omadacycline","approvalYear":"2018","relationship":"same-class"}],"trialDetails":[{"nctId":"NCT02099240","phase":"EARLY_PHASE1","title":"Patients Response to Early Switch To Oral:Osteomyelitis Study","status":"TERMINATED","sponsor":"Julio Ramirez","startDate":"2014-03-06","conditions":["Osteomyelitis"],"enrollment":11,"completionDate":"2018-11-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000146781","NDDF":"002747","UNII":"9GJ0N7ZAP0","VUID":"4018457","CHEBI":"CHEBI:6805","VANDF":"4018457","INN_ID":"1330","RXNORM":"235554","UMLSCUI":"C0025603","chemblId":"CHEMBL249837","ChEMBL_ID":"CHEMBL249837","KEGG_DRUG":"D00849","DRUGBANK_ID":"DB00931","PUBCHEM_CID":"54675785","SNOMEDCT_US":"373527003","SECONDARY_CAS_RN":"3963-95-9","MESH_DESCRIPTOR_UI":"D008690"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"58%"},"publicationCount":52,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"J01AA05","allCodes":["J01AA05"]},"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"","enrichmentLevel":3,"visitCount":0,"regulatoryByCountry":[{"country_code":"US","regulator":"FDA","status":"approved","approval_date":null,"mah":"","brand_name_local":null,"application_number":""},{"country_code":"CA","regulator":"Health Canada","status":"approved","approval_date":null,"mah":"","brand_name_local":"","application_number":""},{"country_code":"IL","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"SG","regulator":"HSA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AE","regulator":"MOH","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"KR","regulator":"MFDS","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"AU","regulator":"TGA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null},{"country_code":"GB","regulator":"MHRA","status":"likely_approved","approval_date":null,"mah":null,"brand_name_local":null,"application_number":null}],"trialStats":{"total":0,"withResults":0},"validation":{"fieldsValidated":0,"lastValidatedAt":"2026-04-20T01:57:20.443428+00:00","fieldsConflicting":1,"overallConfidence":0.8},"verificationStatus":"partial","dataCompleteness":{"mechanism":false,"indications":true,"safety":false,"trials":true,"score":2}}