{"id":"mesterolone","rwe":[{"pmid":"40177353","year":"2025","title":"Illegal and falsified medicines self-administrated in not approved post-cycle therapy after the cessation of anabolic-androgenic steroids - qualitative analysis.","finding":"","journal":"Frontiers in chemistry","studyType":"Clinical Study"},{"pmid":"38482542","year":"2024","title":"Interest of hair tests to discriminate a tail end of a doping regimen from a drug transfer between two individuals in case of challenging an anti-doping rule violation. IV. Case example with mesterolone.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"38045557","year":"2023","title":"Chemical Application of Topological Indices in Infertility Treatment Drugs and QSPR Analysis.","finding":"","journal":"International journal of analytical chemistry","studyType":"Clinical Study"},{"pmid":"37055939","year":"2023","title":"Detection time comparison of non-hydrolysed sulphated metabolites of metenolone, mesterolone and 17α-methyltestosterone analysed by four different mass spectrometric techniques.","finding":"","journal":"Drug testing and analysis","studyType":"Clinical Study"},{"pmid":"36893829","year":"2023","title":"Glomerella fusarioides-catalyzed structural transformation of steroidal drugs mesterolone and methasterone, and anti-inflammatory activity of resulting derivatives.","finding":"","journal":"Steroids","studyType":"Clinical Study"}],"tags":[{"label":"mesterolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"G03BB01","category":"atc"},{"label":"Active","category":"status"},{"label":"Anabolic Agents","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{"safetySignals":[{"llr":87.571,"date":"","count":10,"signal":"Secondary hypogonadism","source":"DrugCentral FAERS","actionTaken":"Reported 10 times (LLR=88)"}],"commonSideEffects":[{"effect":"Secondary hypogonadism","drugRate":"LLR 88","severity":"common"}]},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"androviron","offLabel":[],"synonyms":["mesterolone","androviron","mesteranum","mestoranum"],"timeline":[],"aiSummary":"Androviron is a small molecule with the synonyms ANDROVIRON, MESTEROLONA, MESTEROLONE, MESTEROLONE, MESTEROLONE, and MESTEROLONE.","approvals":[],"brandName":"Androviron","ecosystem":[],"mechanism":{"target":"Sex hormone-binding globulin, Androgen receptor","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"}],"modality":"Small Molecule","drugClass":"mesterolone","explanation":"Think of sex hormone-binding globulin like a protein that wraps around testosterone, making it unavailable for use by the body. Mesterolone binds to this protein, freeing up the testosterone so it can be used by the body. This can help increase energy, libido, and overall sense of well-being.","oneSentence":"Mesterolone works by binding to sex hormone-binding globulin, increasing the amount of free testosterone available in the body.","technicalDetail":"Mesterolone competes with testosterone for binding sites on sex hormone-binding globulin, thereby increasing the concentration of free testosterone in the bloodstream."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3342","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MESTEROLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:36:16.149852","biosimilars":[],"competitors":[{"drugName":"cortisone acetate","drugSlug":"cortisone-acetate","fdaApproval":"1950-06-13","genericCount":12,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"danazol","drugSlug":"danazol","fdaApproval":"1976-06-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"desogestrel","drugSlug":"desogestrel","fdaApproval":"1992-12-10","relationship":"same-target"},{"drugName":"estradiol","drugSlug":"estradiol","fdaApproval":"1975-07-23","patentExpiry":"Nov 21, 2032","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"estradiol benzoate","drugSlug":"estradiol-benzoate","fdaApproval":"","relationship":"same-target"},{"drugName":"estradiol cypionate","drugSlug":"estradiol-cypionate","fdaApproval":"1979-08-15","genericCount":2,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"estriol","drugSlug":"estriol","fdaApproval":"","relationship":"same-target"},{"drugName":"estrone","drugSlug":"estrone","fdaApproval":"1979-02-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"ethinylestradiol","drugSlug":"ethinylestradiol","fdaApproval":"1943-06-25","relationship":"same-target"},{"drugName":"etonogestrel","drugSlug":"etonogestrel","fdaApproval":"2001-10-03","patentExpiry":"Sep 28, 2027","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"mesterolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"cortisone-acetate","brandName":"cortisone acetate","genericName":"cortisone acetate","approvalYear":"1950","relationship":"same-target"},{"drugId":"danazol","brandName":"danazol","genericName":"danazol","approvalYear":"1976","relationship":"same-target"},{"drugId":"desogestrel","brandName":"desogestrel","genericName":"desogestrel","approvalYear":"1992","relationship":"same-target"},{"drugId":"estradiol","brandName":"estradiol","genericName":"estradiol","approvalYear":"1975","relationship":"same-target"},{"drugId":"estradiol-benzoate","brandName":"estradiol benzoate","genericName":"estradiol benzoate","approvalYear":"","relationship":"same-target"},{"drugId":"estradiol-cypionate","brandName":"estradiol cypionate","genericName":"estradiol cypionate","approvalYear":"1979","relationship":"same-target"},{"drugId":"estriol","brandName":"estriol","genericName":"estriol","approvalYear":"","relationship":"same-target"},{"drugId":"estrone","brandName":"estrone","genericName":"estrone","approvalYear":"1979","relationship":"same-target"},{"drugId":"ethinylestradiol","brandName":"ethinylestradiol","genericName":"ethinylestradiol","approvalYear":"1943","relationship":"same-target"},{"drugId":"etonogestrel","brandName":"etonogestrel","genericName":"etonogestrel","approvalYear":"2001","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NUI":"N0000167465","NDDF":"004004","UNII":"0SRQ75X9I9","CHEBI":"CHEBI:135293","INN_ID":"1965","RXNORM":"6781","UMLSCUI":"C0025503","ChEMBL_ID":"CHEMBL258918","KEGG_DRUG":"D04947","DRUGBANK_ID":"DB13587","PUBCHEM_CID":"15020","SNOMEDCT_US":"126166005","MESH_DESCRIPTOR_UI":"D008655"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"pharmacokinetics":{"source":"DrugCentral","bioavailability":"3%"},"publicationCount":153,"therapeuticAreas":["Hematology"],"atcClassification":{"source":"DrugCentral","atcCode":"G03BB01","allCodes":["G03BB01"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025","pmid":"40177353","title":"Illegal and falsified medicines self-administrated in not approved post-cycle therapy after the cessation of anabolic-androgenic steroids - 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Case example with mesterolone.","journal":"Drug testing and analysis"},{"date":"2023","pmid":"38045557","title":"Chemical Application of Topological Indices in Infertility Treatment Drugs and QSPR Analysis.","journal":"International journal of analytical chemistry"},{"date":"2023 Aug","pmid":"37055939","title":"Detection time comparison of non-hydrolysed sulphated metabolites of metenolone, mesterolone and 17α-methyltestosterone analysed by four different mass spectrometric techniques.","journal":"Drug testing and analysis"},{"date":"2023 Jun","pmid":"36893829","title":"Glomerella fusarioides-catalyzed structural transformation of steroidal drugs mesterolone and methasterone, and anti-inflammatory activity of resulting derivatives.","journal":"Steroids"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","enrichmentLevel":3,"visitCount":2,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":true,"trials":false,"score":2}}