{"id":"mestanolone","rwe":[],"tags":[{"label":"mestanolone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Sex hormone-binding globulin","category":"target"},{"label":"SHBG","category":"gene"},{"label":"AR","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"mesanolon","offLabel":[],"synonyms":["mestaline","mesanolon","mestanolone","mestalone","mestanolon","methylandrostanolone","methylantalon"],"timeline":[],"approvals":[],"brandName":"Mesanolon","ecosystem":[],"mechanism":{"target":"Sex hormone-binding globulin, Androgen receptor","targets":[{"gene":"SHBG","source":"DrugCentral","target":"Sex hormone-binding globulin","protein":"Sex hormone-binding globulin"},{"gene":"AR","source":"DrugCentral","target":"Androgen receptor","protein":"Androgen receptor"}],"modality":"Small Molecule","drugClass":"mestanolone","explanation":"Think of sex hormone-binding globulin like a key that unlocks the cells where sex hormones live. By binding to this key, mesanolone can affect how sex hormones are delivered to the cells, which can impact various bodily functions. This can potentially lead to changes in hormone levels and related symptoms.","oneSentence":"Mesanolone works by binding to sex hormone-binding globulin, which is a protein that regulates the levels of sex hormones in the body.","technicalDetail":"Mesanolone acts as a competitive inhibitor of sex hormone-binding globulin, thereby increasing the levels of free sex hormones in the bloodstream and potentially influencing various physiological processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3341","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MESTANOLONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:01:54.637362","biosimilars":[],"competitors":[{"drugName":"abiraterone acetate","drugSlug":"abiraterone-acetate","fdaApproval":"2011-04-28","patentExpiry":"May 20, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"apalutamide","drugSlug":"apalutamide","fdaApproval":"2018-02-14","patentExpiry":"Sep 23, 2033","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"bicalutamide","drugSlug":"bicalutamide","fdaApproval":"1995-10-04","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"clascoterone","drugSlug":"clascoterone","fdaApproval":"2020-08-26","patentExpiry":"Nov 20, 2028","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"danazol","drugSlug":"danazol","fdaApproval":"1976-06-21","genericCount":3,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"darolutamide","drugSlug":"darolutamide","fdaApproval":"2019-07-30","patentExpiry":"Oct 27, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"dexamethasone","drugSlug":"dexamethasone","fdaApproval":"1958-10-30","patentExpiry":"Oct 7, 2036","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"dexamethasone phosphate","drugSlug":"dexamethasone-phosphate","fdaApproval":"1959-09-02","relationship":"same-target"},{"drugName":"dorzolamide","drugSlug":"dorzolamide","fdaApproval":"1994-12-09","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"drospirenone","drugSlug":"drospirenone","fdaApproval":"2019-05-23","patentExpiry":"Jun 28, 2031","patentStatus":"Patent protected","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"mestanolone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"abiraterone-acetate","brandName":"abiraterone acetate","genericName":"abiraterone acetate","approvalYear":"2011","relationship":"same-target"},{"drugId":"apalutamide","brandName":"apalutamide","genericName":"apalutamide","approvalYear":"2018","relationship":"same-target"},{"drugId":"bicalutamide","brandName":"bicalutamide","genericName":"bicalutamide","approvalYear":"1995","relationship":"same-target"},{"drugId":"clascoterone","brandName":"clascoterone","genericName":"clascoterone","approvalYear":"2020","relationship":"same-target"},{"drugId":"danazol","brandName":"danazol","genericName":"danazol","approvalYear":"1976","relationship":"same-target"},{"drugId":"darolutamide","brandName":"darolutamide","genericName":"darolutamide","approvalYear":"2019","relationship":"same-target"},{"drugId":"dexamethasone","brandName":"dexamethasone","genericName":"dexamethasone","approvalYear":"1958","relationship":"same-target"},{"drugId":"dexamethasone-phosphate","brandName":"dexamethasone phosphate","genericName":"dexamethasone phosphate","approvalYear":"1959","relationship":"same-target"},{"drugId":"dorzolamide","brandName":"dorzolamide","genericName":"dorzolamide","approvalYear":"1994","relationship":"same-target"},{"drugId":"drospirenone","brandName":"drospirenone","genericName":"drospirenone","approvalYear":"2019","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"UNII":"S712YZ168E","CHEBI":"CHEBI:31825","INN_ID":"862","UMLSCUI":"C0066031","ChEMBL_ID":"CHEMBL261514","KEGG_DRUG":"D01533","PUBCHEM_CID":"10633","MESH_SUPPLEMENTAL_RECORD_UI":"C008376"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":21,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mesanolone (MESTANOLONE) is a small molecule drug that targets sex hormone-binding globulin. It is classified as a mestanolone, but its commercial status and approved indications are unknown. The mechanism of action involves binding to sex hormone-binding globulin, but further details are not available. As a result, key safety considerations and pharmacokinetic properties such as half-life and bioavailability are also unknown. Further research is needed to determine its potential therapeutic applications.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}