{"id":"mercurochrome","rwe":[{"pmid":"41091520","year":"2025","title":"Irritant and sensitizing potential of antiseptics and disinfectants: an overview.","finding":"","journal":"Italian journal of dermatology and venereology","studyType":"Clinical Study"},{"pmid":"40667075","year":"2025","title":"OocystMeter, a machine-learning algorithm to count and measure Plasmodium oocysts, reveals clustering patterns in the Anopheles midgut.","finding":"","journal":"bioRxiv : the preprint server for biology","studyType":"Clinical Study"},{"pmid":"39367453","year":"2024","title":"Human-to-Anopheles dirus mosquito transmission of the anthropozoonotic malaria parasite, Plasmodium knowlesi.","finding":"","journal":"Parasites & vectors","studyType":"Clinical Study"},{"pmid":"38955371","year":"2024","title":"The interactive effects of medicinal dyes with conventional antimicrobials against skin pathogens.","finding":"","journal":"Journal of applied microbiology","studyType":"Clinical Study"},{"pmid":"38332466","year":"2024","title":"Determination of omeprazole via fluorescence-quenching methodology; application to content uniformity testing.","finding":"","journal":"Luminescence : the journal of biological and chemical luminescence","studyType":"Clinical Study"}],"tags":[{"label":"mercurochrome","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"D08AK04","category":"atc"},{"label":"Active","category":"status"},{"label":"Antiseptic preparation","category":"indication"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"merbromin","offLabel":[],"synonyms":["mercurodibromofluorescein","mercurochrome","merbromin","mercuranine","mercuresceine","mercurichrome","mercurocol"],"timeline":[],"approvals":[],"brandName":"Merbromin","ecosystem":[{"indication":"Antiseptic preparation","otherDrugs":[{"name":"boric acid","slug":"boric-acid","company":""},{"name":"chloroxylenol","slug":"chloroxylenol","company":""},{"name":"ethanol","slug":"ethanol","company":"B Braun"},{"name":"hydrogen peroxide","slug":"hydrogen-peroxide","company":""}],"globalPrevalence":null}],"mechanism":{"modality":"Small Molecule","drugClass":"mercurochrome","explanation":"Think of it like a strong detergent that breaks down the 'walls' of bacteria, making it impossible for them to survive. This allows the body's natural defenses to take over and heal the wound. Merbromin's mercury ions are the active ingredient that does the damage to bacteria.","oneSentence":"Merbromin works by releasing mercury ions that disrupt bacterial cell membranes, ultimately killing the bacteria.","technicalDetail":"Merbromin's mechanism of action involves the release of mercuric ions (Hg2+), which bind to bacterial cell membranes and disrupt their function, ultimately leading to bacterial cell death through a process known as 'mercurial inactivation'."},"_wikipedia":{"url":"https://en.wikipedia.org/wiki/Merbromin","title":"Merbromin","extract":"Merbromin is an organomercuric disodium salt compound used as a topical antiseptic for minor cuts and scrapes and as a biological dye. While readily available in most countries, it is no longer sold in much of the West, including Switzerland, Brazil, France, Iran, Germany, Denmark, or the United States, due to its mercury content."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/4788","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=mercurochrome","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mercurochrome","fields":["publications"],"source":"PubMed/NCBI"},{"id":4,"url":"https://en.wikipedia.org/wiki/Merbromin","fields":["history","overview"],"source":"Wikipedia"}],"_enrichedAt":"2026-03-30T14:20:12.066979","biosimilars":[],"competitors":[],"genericName":"mercurochrome","indications":{"approved":[{"name":"Antiseptic preparation","source":"DrugCentral","snomedId":261276004,"regulator":"FDA"}],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT02695706","phase":"EARLY_PHASE1","title":"Clinical Study, Opened, of Cutaneous Acceptability of a Topic Product in Normal Conditions of Use","status":"UNKNOWN","sponsor":"LM Farma Indústria e Comércio Ltda.","startDate":"2016-04","conditions":["Diabetes"],"enrollment":35,"completionDate":"2016-07"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000148151","MMSL":"NOCODE","NDDF":"003129","UNII":"M0T18YH28D","VUID":"4020260","CHEBI":"CHEBI:6763","VANDF":"4020260","INN_ID":"4191","RXNORM":"6762","UMLSCUI":"C0947682","ChEMBL_ID":"CHEMBL3833381","KEGG_DRUG":"D00861","DRUGBANK_ID":"DB13392","PUBCHEM_CID":"8505","SNOMEDCT_US":"19126005","MESH_DESCRIPTOR_UI":"D008622"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":171,"therapeuticAreas":["Infectious Disease"],"atcClassification":{"source":"DrugCentral","atcCode":"D08AK04","allCodes":["D08AK04"]},"biosimilarFilings":[],"recentPublications":[{"date":"2025 Dec","pmid":"41091520","title":"Irritant and sensitizing potential of antiseptics and disinfectants: an overview.","journal":"Italian journal of dermatology and venereology"},{"date":"2025 Jun 29","pmid":"40667075","title":"OocystMeter, a machine-learning algorithm to count and measure Plasmodium oocysts, reveals clustering patterns in the Anopheles midgut.","journal":"bioRxiv : the preprint server for biology"},{"date":"2024 Oct 4","pmid":"39367453","title":"Human-to-Anopheles dirus mosquito transmission of the anthropozoonotic malaria parasite, Plasmodium knowlesi.","journal":"Parasites & vectors"},{"date":"2024 Jul 2","pmid":"38955371","title":"The interactive effects of medicinal dyes with conventional antimicrobials against skin pathogens.","journal":"Journal of applied microbiology"},{"date":"2024 Feb","pmid":"38332466","title":"Determination of omeprazole via fluorescence-quenching methodology; application to content uniformity testing.","journal":"Luminescence : the journal of biological and chemical luminescence"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Merbromin is a small molecule organomercuric disodium salt compound used as a topical antiseptic for minor cuts and scrapes. It has been studied in clinical trials for conditions including diabetes, and is also used as a biological dye.","enrichmentLevel":3,"visitCount":1,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":false,"trials":true,"score":3}}