{"id":"mercaptopurine-tablet","safety":{"commonSideEffects":[{"rate":"40-60","effect":"Myelosuppression (leukopenia, thrombocytopenia, anemia)"},{"rate":"20-30","effect":"Nausea and vomiting"},{"rate":"10-20","effect":"Hepatotoxicity"},{"rate":"15-25","effect":"Infection"},{"rate":"10-15","effect":"Mucositis"},{"rate":"5-10","effect":"Diarrhea"}]},"_chembl":{"chemblId":"CHEMBL1425","moleculeType":"Small molecule","molecularWeight":"152.18"},"_dailymed":null,"mechanism":{"_ai_source":"anthropic-haiku","explanation":"Mercaptopurine is converted intracellularly to active metabolites that inhibit both de novo and salvage pathways of purine synthesis, thereby depleting cellular nucleotide pools and preventing DNA synthesis. This mechanism is particularly effective against leukemic and lymphoid cells, which have high proliferation rates. The drug also has immunosuppressive properties due to its effects on lymphocyte proliferation.","oneSentence":"Mercaptopurine is a purine analog that inhibits nucleotide synthesis and DNA replication, leading to cell death in rapidly dividing cells.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:20:46.272Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Acute lymphoblastic leukemia (ALL)"},{"name":"Acute myeloid leukemia (AML)"},{"name":"Chronic myeloid leukemia (CML)"}]},"trialDetails":[{"nctId":"NCT03164473","phase":"PHASE3","title":"Maintenance of Remission With Rituximab Versus Azathioprine for Newly-diagnosed or Relapsing Eosinophilic Granulomatosis With Polyangiitis.","status":"COMPLETED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2018-03-07","conditions":"Eosinophilic Granulomatosis With Polyangiitis","enrollment":98},{"nctId":"NCT07227584","phase":"PHASE2","title":"ALL Backbone in AYAs","status":"NOT_YET_RECRUITING","sponsor":"Dana-Farber Cancer Institute","startDate":"2026-04","conditions":"Acute Lymphoblastic Leukemia, Philadelphia Chromosome-Negative Lymphoblastic Leukemia, Acute Lymphoblastic Leukemia (ALL)","enrollment":67},{"nctId":"NCT06476366","phase":"EARLY_PHASE1","title":"Comparison of Efficacy of Methotrexate and Azathioprine in Patients With Chronic Actinic Dermatitis: A Randomized Controlled Trial","status":"COMPLETED","sponsor":"Pak Emirates Military Hospital","startDate":"2024-07-14","conditions":"Chronic Actinic Dermatitis","enrollment":20},{"nctId":"NCT00866684","phase":"PHASE4","title":"Prevention of Skin Cancer in High Risk Patients After Conversion to a Sirolimus-based Immunosuppressive Protocol","status":"TERMINATED","sponsor":"Charite University, Berlin, Germany","startDate":"2007-01-01","conditions":"Skin Cancer","enrollment":44},{"nctId":"NCT04469842","phase":"EARLY_PHASE1","title":"Early Use of Long-acting Tacrolimus in Lung Transplant Recipients","status":"RECRUITING","sponsor":"Vanderbilt University Medical Center","startDate":"2023-12-01","conditions":"Lung Transplant; Complications","enrollment":48},{"nctId":"NCT00648336","phase":"PHASE1","title":"Fasting Study of Mercaptopurine 50 mg and Purinethol® Tablets 50 mg","status":"COMPLETED","sponsor":"Mylan Pharmaceuticals Inc","startDate":"2003-11","conditions":"Healthy","enrollment":60},{"nctId":"NCT05965284","phase":"PHASE4","title":"Efficacy and Safety for Telitacicept in the Remission Maintenance Treatment of ANCA-associated Vasculitis (TTCAZAREM)","status":"RECRUITING","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2023-03-09","conditions":"ANCA-associated Vasculitis, Maintenance Therapy","enrollment":40},{"nctId":"NCT05896605","phase":"PHASE4","title":"Monitoring of Azathioprine Metabolite Concentrations and Cytokine Levels in Neuromyelitis Optica Spectrum Disorder","status":"COMPLETED","sponsor":"First Affiliated Hospital of Guangxi Medical University","startDate":"2020-01-01","conditions":"NMO Spectrum Disorder, Azathioprine Adverse Reaction","enrollment":63},{"nctId":"NCT02444728","phase":"PHASE3","title":"Cyclophosphamide and Hydroxychloroquine for Thrombocytopenia in SLE","status":"TERMINATED","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2015-07","conditions":"Thrombocytopenia","enrollment":50},{"nctId":"NCT04737343","phase":"NA","title":"Comparison of the Efficacy of Leflunomide and Azathioprine for the Maintenance Therapy of ANCA Associated Vasculitis","status":"UNKNOWN","sponsor":"Chinese SLE Treatment And Research Group","startDate":"2021-06-30","conditions":"ANCA Associated Vasculitis, Maintenance Therapy","enrollment":114},{"nctId":"NCT03930264","phase":"PHASE1","title":"Bioequivalence of Azathioprine Suspension 10 mg/mL (Jayempi) Versus Azathioprine Tablet 50mg (Imurek®)","status":"COMPLETED","sponsor":"Nova Laboratories Limited","startDate":"2019-04-11","conditions":"Therapeutic Equivalency","enrollment":30},{"nctId":"NCT03490539","phase":"","title":"Disease-Modifying Treatments for Myasthenia Gravis","status":"COMPLETED","sponsor":"Duke University","startDate":"2018-05-07","conditions":"Neurological Disorder, Autoimmune Diseases","enrollment":167},{"nctId":"NCT01324336","phase":"","title":"Comparative Pharmacokinetics of a Compounded 6-mercaptopurine Liquid Formulation Preparation and Tablets","status":"COMPLETED","sponsor":"Children's Mercy Hospital Kansas City","startDate":"2011-07","conditions":"Acute Lymphoblastic Leukemia","enrollment":40},{"nctId":"NCT03002038","phase":"PHASE2, PHASE3","title":"Comparison of Clinical Effects of Azathioprine and Rituximab NMO-SD Patients","status":"COMPLETED","sponsor":"Isfahan University of Medical Sciences","startDate":"2015-09","conditions":"Neuromyelitis Optica Spectrum Disorder","enrollment":86},{"nctId":"NCT00608894","phase":"PHASE2","title":"LCP-Tacro vs. Azathioprine for the Treatment of Autoimmune Hepatitis","status":"TERMINATED","sponsor":"Veloxis Pharmaceuticals","startDate":"2007-12","conditions":"Autoimmune Hepatitis","enrollment":13},{"nctId":"NCT03498703","phase":"PHASE2","title":"Azathioprine in Recurrent Implantation Failure","status":"COMPLETED","sponsor":"Ain Shams University","startDate":"2018-04-25","conditions":"Recurrent Implantation Failure, In Vitro Fertilization, Intracytoplsmic Sperm Injection","enrollment":64},{"nctId":"NCT00968253","phase":"PHASE1, PHASE2","title":"RAD001 Study in Treatment of Relapsed or Refractory Acute Lymphocytic Leukemia","status":"COMPLETED","sponsor":"M.D. Anderson Cancer Center","startDate":"2009-11","conditions":"Leukemia, Acute Lymphocytic Leukemia","enrollment":24},{"nctId":"NCT03229746","phase":"PHASE4","title":"Reposition of Second Line Treatment in Chronic Immune Thrombocytopenia","status":"COMPLETED","sponsor":"Assiut University","startDate":"2017-08-01","conditions":"Immune Thrombocytopenia","enrollment":40},{"nctId":"NCT03026907","phase":"PHASE3","title":"Alitretinoin vs Azathioprine in Severe Non-hyperkeratotic Hand Eczema","status":"UNKNOWN","sponsor":"University Medical Center Groningen","startDate":"2016-05","conditions":"Hand Eczema","enrollment":116},{"nctId":"NCT01906671","phase":"PHASE4","title":"Study on Two Different Formulations of 6-mercaptopurine. Tablet Versus Oral Liquid","status":"UNKNOWN","sponsor":"Kjeld Schmiegelow","startDate":"2013-06","conditions":"Acute Lymphoblastic Leukemia, 6-mercaptopurine Therapy","enrollment":16},{"nctId":"NCT00602134","phase":"NA","title":"Bioequivalence Study of 6-Mercaptopurine Under Fasting Conditions","status":"COMPLETED","sponsor":"Roxane Laboratories","startDate":"2002-11","conditions":"Acute Lymphoblastic Leukemia","enrollment":54},{"nctId":"NCT00537316","phase":"PHASE3","title":"Efficacy & Safety of Infliximab Monotherapy Vs Combination Therapy Vs AZA Monotherapy in Ulcerative Colitis (Part 1) Maintenance Vs Intermittent Therapy for Maintaining Remission (Part 2)(Study P04807)","status":"TERMINATED","sponsor":"Merck Sharp & Dohme LLC","startDate":"2007-07","conditions":"Ulcerative Colitis","enrollment":242},{"nctId":"NCT02949349","phase":"PHASE2","title":"Mycophenolate Mofetil Versus Azathioprine for Maintenance Therapy of Lupus Nephritis","status":"COMPLETED","sponsor":"Genovate Biotechnology Co., Ltd.,","startDate":"2015-07","conditions":"Lupus Nephritis","enrollment":32},{"nctId":"NCT02998827","phase":"NA","title":"Thalidomide Results in Diminished Ovarian Reserve in Reproductive Age Female IBD Patients","status":"UNKNOWN","sponsor":"Sixth Affiliated Hospital, Sun Yat-sen University","startDate":"2016-11","conditions":"Crohn Disease","enrollment":90},{"nctId":"NCT00109837","phase":"PHASE2","title":"S0333 Combination Chemotherapy in Treating Patients With Newly Diagnosed Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"SWOG Cancer Research Network","startDate":"2005-04","conditions":"Leukemia","enrollment":79},{"nctId":"NCT00022737","phase":"PHASE3","title":"Combination Chemotherapy With or Without Peripheral Stem Cell Transplant in Treating Children With Acute Lymphoblastic Leukemia","status":"COMPLETED","sponsor":"National Cancer Institute (NCI)","startDate":"2002-10","conditions":"Childhood Acute Lymphoblastic Leukemia in Remission, Recurrent Childhood Acute Lymphoblastic Leukemia","enrollment":220},{"nctId":"NCT01697020","phase":"PHASE1","title":"Bioequivalence of An Oral Mercaptopurine Suspension 100 Mg / 5 Ml Versus Tablet in Healthy Male Subjects Under Fasting Conditions","status":"COMPLETED","sponsor":"Nova Laboratories Limited","startDate":"2012-09","conditions":"Acute Lymphoblastic Leukemia","enrollment":70},{"nctId":"NCT01381432","phase":"","title":"Special Drug Use Investigation for IMURAN (Azathioprine) Tablet (Pulmones Transplantation)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2004-12","conditions":"Liver Diseases","enrollment":39},{"nctId":"NCT01817972","phase":"PHASE3","title":"Cimzia Versus Cimzia Plus Azathioprine in the Treatment of Active Crohn's Disease","status":"UNKNOWN","sponsor":"Gastroenterology Research of America","startDate":"2013-03","conditions":"Crohn's Disease","enrollment":65},{"nctId":"NCT01094613","phase":"PHASE1, PHASE2","title":"Multicenter Clinical Efficacy and Safety Study of Delayed Release 6MP in Crohn's Disease","status":"TERMINATED","sponsor":"Teva GTC","startDate":"2010-11","conditions":"Crohn's Disease","enrollment":70},{"nctId":"NCT01433432","phase":"PHASE2","title":"Open Label Extension Study to Protocol C2/13/DR-6MP-02","status":"WITHDRAWN","sponsor":"Teva GTC","startDate":"2011-10","conditions":"Crohn's Disease","enrollment":""},{"nctId":"NCT00768729","phase":"PHASE1","title":"Safety of Immunosuppression Minimization in Children and Adolescents After Kidney Transplantation","status":"COMPLETED","sponsor":"National Institute of Allergy and Infectious Diseases (NIAID)","startDate":"2009-05","conditions":"Kidney Failure, Chronic, Kidney Transplantation, Immunosuppression","enrollment":7},{"nctId":"NCT01390766","phase":"","title":"Drug Use Investigation for IMURAN (Azathioprine) Tablet (Hepatic Transplantation)","status":"COMPLETED","sponsor":"GlaxoSmithKline","startDate":"2002-08","conditions":"Liver Diseases","enrollment":41},{"nctId":"NCT00946946","phase":"PHASE3","title":"Preventing Postoperative Relapse in Crohn's Disease Patients at Risk: Azathioprine Versus Mesalazine","status":"COMPLETED","sponsor":"Dr. Falk Pharma GmbH","startDate":"2002-02","conditions":"Crohn's Disease","enrollment":78},{"nctId":"NCT00849368","phase":"PHASE1","title":"Azathioprine & Allopurinol in Inflammatory Bowel Disease Patients","status":"COMPLETED","sponsor":"University of Zurich","startDate":"2009-01","conditions":"Inflammatory Bowel Disease","enrollment":6},{"nctId":"NCT00377637","phase":"PHASE3","title":"A Study of Mycophenolate Mofetil (CellCept) in Management of Patients With Lupus Nephritis.","status":"COMPLETED","sponsor":"Hoffmann-La Roche","startDate":"2005-07","conditions":"Lupus Nephritis","enrollment":370},{"nctId":"NCT00774982","phase":"PHASE1","title":"Pilot Comparative Bioavailability Study of 6Mercaptopurine (Delayed Release vs. Purinethol) in Crohns Disease Patients","status":"COMPLETED","sponsor":"Teva GTC","startDate":"2008-12","conditions":"Crohns Disease","enrollment":12}],"_emaApprovals":[],"_faersSignals":[{"count":1,"reaction":"ACUTE LYMPHOCYTIC LEUKAEMIA RECURRENT"},{"count":1,"reaction":"ALANINE AMINOTRANSFERASE INCREASED"},{"count":1,"reaction":"ANGER"},{"count":1,"reaction":"ANXIETY"},{"count":1,"reaction":"ASPARTATE AMINOTRANSFERASE INCREASED"},{"count":1,"reaction":"BLOOD BILIRUBIN INCREASED"},{"count":1,"reaction":"BLOOD LACTATE DEHYDROGENASE INCREASED"},{"count":1,"reaction":"CENTRAL NERVOUS SYSTEM LEUKAEMIA"},{"count":1,"reaction":"CEREBRAL HAEMORRHAGE"},{"count":1,"reaction":"CONDITION AGGRAVATED"}],"_approvalHistory":[],"publicationCount":41,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["6-mercaptopurine","6-MP","Leukerin","MP","6-MP Oral Suspension"],"phase":"phase_3","status":"active","brandName":"mercaptopurine tablet","genericName":"mercaptopurine tablet","companyName":"National Cancer Institute (NCI)","companyId":"national-cancer-institute-nci","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mercaptopurine is a purine analog that inhibits nucleotide synthesis and DNA replication, leading to cell death in rapidly dividing cells. Used for Acute lymphoblastic leukemia (ALL), Acute myeloid leukemia (AML), Chronic myeloid leukemia (CML).","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}