{"id":"meproscillarin","rwe":[{"pmid":"7976380","year":"1994","title":"[Inhibitory effects of 6 cardiac glycosides on sodium pump in sheep Purkinje fibers].","finding":"","journal":"Zhongguo yao li xue bao = Acta pharmacologica Sinica","studyType":"Clinical Study"},{"pmid":"6206318","year":"1984","title":"A comparative dose-effect study with cardiac glycosides assessing cardiac and extracardiac responses in normal subjects.","finding":"","journal":"Journal of cardiovascular pharmacology","studyType":"Clinical Study"},{"pmid":"6845784","year":"1983","title":"[Plasma concentration and elimination behavior of the cardiac glycoside meproscillarin in patients with liver cirrhosis].","finding":"","journal":"Zeitschrift fur Gastroenterologie","studyType":"Clinical Study"},{"pmid":"7001203","year":"1980","title":"[Threshold of action of meproscillarin following intravenous administration].","finding":"","journal":"Medizinische Klinik","studyType":"Clinical Study"},{"pmid":"7374099","year":"1980","title":"The effect of cathartic agents on transmucosal electrical potential difference in the human rectum.","finding":"","journal":"Klinische Wochenschrift","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Sodium/potassium-transporting ATPase subunit alpha-1","category":"target"},{"label":"ATP1A1","category":"gene"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"methyl proscillaridin a","offLabel":[],"synonyms":["meproscillarin","methyl proscillaridin","Methyl proscillaridin A","Proscillaridin 4-methyl ether"],"timeline":[],"approvals":[],"brandName":"Methyl Proscillaridin A","ecosystem":[],"mechanism":{"target":"Sodium/potassium-transporting ATPase subunit alpha-1","targets":[{"gene":"ATP1A1","source":"DrugCentral","target":"Sodium/potassium-transporting ATPase subunit alpha-1","protein":"Sodium/potassium-transporting ATPase subunit alpha-1"}],"modality":"Small Molecule","explanation":"Think of it like a pump in your body that helps move sodium and potassium in and out of cells. Methyl Proscillaridin A blocks this pump, which can affect how your body regulates these important minerals. This can have various effects on the body, but the exact impact depends on the specific condition being treated.","oneSentence":"Methyl Proscillaridin A works by inhibiting the sodium/potassium-transporting ATPase subunit alpha-1.","technicalDetail":"Methyl Proscillaridin A acts as a competitive inhibitor of the sodium/potassium-transporting ATPase subunit alpha-1, binding to the enzyme's active site and reducing its ability to transport sodium and potassium ions across cell membranes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1705","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEPROSCILLARIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:34:57.529565","biosimilars":[],"competitors":[{"drugName":"bumetanide","drugSlug":"bumetanide","fdaApproval":"1983-02-28","patentExpiry":"Dec 4, 2040","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"digitoxin","drugSlug":"digitoxin","fdaApproval":"","genericCount":1,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"furosemide","drugSlug":"furosemide","fdaApproval":"1966-07-01","patentExpiry":"Apr 3, 2034","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"pantoprazole","drugSlug":"pantoprazole","fdaApproval":"2000-02-02","patentExpiry":"Jun 7, 2026","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"rabeprazole","drugSlug":"rabeprazole","fdaApproval":"1999-08-19","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"meproscillarin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"bumetanide","brandName":"bumetanide","genericName":"bumetanide","approvalYear":"1983","relationship":"same-target"},{"drugId":"digitoxin","brandName":"digitoxin","genericName":"digitoxin","approvalYear":"","relationship":"same-target"},{"drugId":"furosemide","brandName":"furosemide","genericName":"furosemide","approvalYear":"1966","relationship":"same-target"},{"drugId":"pantoprazole","brandName":"pantoprazole","genericName":"pantoprazole","approvalYear":"2000","relationship":"same-target"},{"drugId":"rabeprazole","brandName":"rabeprazole","genericName":"rabeprazole","approvalYear":"1999","relationship":"same-target"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"006573","UNII":"WYR1723LO7","CHEBI":"CHEBI:135824","INN_ID":"4012","UMLSCUI":"C0065971","ChEMBL_ID":"CHEMBL2106427","PUBCHEM_CID":"15942714","MESH_SUPPLEMENTAL_RECORD_UI":"C009079"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":26,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"1994 May","pmid":"7976380","title":"[Inhibitory effects of 6 cardiac glycosides on sodium pump in sheep Purkinje fibers].","journal":"Zhongguo yao li xue bao = Acta pharmacologica Sinica"},{"date":"1984 Jul-Aug","pmid":"6206318","title":"A comparative dose-effect study with cardiac glycosides assessing cardiac and extracardiac responses in normal subjects.","journal":"Journal of cardiovascular pharmacology"},{"date":"1983 Jan","pmid":"6845784","title":"[Plasma concentration and elimination behavior of the cardiac glycoside meproscillarin in patients with liver cirrhosis].","journal":"Zeitschrift fur Gastroenterologie"},{"date":"1980 Jul 18","pmid":"7001203","title":"[Threshold of action of meproscillarin following intravenous administration].","journal":"Medizinische Klinik"},{"date":"1980 Mar 17","pmid":"7374099","title":"The effect of cathartic agents on transmucosal electrical potential difference in the human rectum.","journal":"Klinische Wochenschrift"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Methyl Proscillaridin A (MEPROSCILLARIN) is a small molecule drug targeting the sodium/potassium-transporting ATPase subunit alpha-1. Its mechanism of action and approved indications are not well-documented, and it is unclear if it is FDA-approved or commercially available. Further research is needed to determine its clinical utility and safety profile. As a result, it is not possible to provide a comprehensive summary of its commercial status or key safety considerations. More information is required to accurately describe this compound.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}