{"id":"mepivacaine-2-with-epinephrine-1-100-000","safety":{"commonSideEffects":[{"rate":"10-20%","effect":"Numbness or tingling"},{"rate":"5-10%","effect":"Headache"},{"rate":"5-10%","effect":"Dizziness"},{"rate":"5-10%","effect":"Nausea"},{"rate":"5-10%","effect":"Vasodilation"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"groq-llama-8b","explanation":"Mepivacaine works by inhibiting the influx of sodium ions into nerve cells, which prevents the initiation and transmission of nerve impulses. This results in a temporary loss of sensation in the affected area. Epinephrine, added to the solution, causes vasoconstriction, which reduces bleeding and prolongs the duration of the anesthetic effect.","oneSentence":"Mepivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while epinephrine constricts blood vessels to prolong the anesthetic effect.","_ai_confidence":"high"},"_scrapedAt":"2026-03-28T01:20:55.401Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Local anesthesia for surgical procedures, dental procedures, and other painful conditions"}]},"trialDetails":[],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":9,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["medicaine 2%"],"phase":"phase_3","status":"active","brandName":"Mepivacaine 2% with epinephrine 1:100,000","genericName":"Mepivacaine 2% with epinephrine 1:100,000","companyName":"Qassim Health Cluster","companyId":"qassim-health-cluster","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Mepivacaine is a local anesthetic that blocks sodium channels to prevent nerve impulses, while epinephrine constricts blood vessels to prolong the anesthetic effect. Used for Local anesthesia for surgical procedures, dental procedures, and other painful conditions.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":false,"score":3}}