{"id":"mepitiostane","rwe":[{"pmid":"26247800","year":"2015","title":"Determination of mepitiostane metabolites in human urine by liquid chromatography/tandem mass spectrometry for sports drug testing.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"25082321","year":"2014","title":"[Effect of an oral anti-estrogen agent (mepitiostane) on the regression of intracranial meningiomas in the elderly].","finding":"","journal":"Brain and nerve = Shinkei kenkyu no shinpo","studyType":"Clinical Study"},{"pmid":"11244236","year":"2001","title":"Unusual annular erythema associated with myelodysplastic syndrome.","finding":"","journal":"Dermatology (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"10883917","year":"2000","title":"Regression of a presumed meningioma with the antiestrogen agent mepitiostane. Case report.","finding":"","journal":"Journal of neurosurgery","studyType":"Clinical Study"},{"pmid":"8058606","year":"1994","title":"A quantitative concept of the mechanism of intestinal lymphatic transfer of lipophilic molecules.","finding":"","journal":"Pharmaceutical research","studyType":"Clinical Study"}],"tags":[{"label":"mepitiostane","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Anabolic Agents","category":"pharmacology"},{"label":"Antineoplastic Agents","category":"pharmacology"},{"label":"Estrogen Antagonists","category":"pharmacology"},{"label":"Hormone Antagonists","category":"pharmacology"},{"label":"Hormones","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"thioderon","offLabel":[],"synonyms":["S-10364","thioderon","mepitiostane"],"timeline":[],"approvals":[],"brandName":"Thioderon","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mepitiostane","explanation":"Think of Thioderon like a key that fits into a lock, but we don't know what the lock is or what it does. When it binds to its target, it can affect various cellular processes, but the specific effects are still unknown. More research is needed to understand how Thioderon works and what it does to the body.","oneSentence":"Thioderon works by inhibiting an unknown target, but its exact mechanism of action is not well understood.","technicalDetail":"Thioderon is a small molecule inhibitor that binds to an unknown target, potentially affecting downstream signaling pathways and cellular processes."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1699","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEPITIOSTANE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:34:46.958860","biosimilars":[],"competitors":[],"genericName":"mepitiostane","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"O00404969K","CHEBI":"CHEBI:31818","INN_ID":"3915","UMLSCUI":"C0065964","ChEMBL_ID":"CHEMBL2104860","KEGG_DRUG":"D01602","PUBCHEM_CID":"9909202","MESH_SUPPLEMENTAL_RECORD_UI":"C006242"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":29,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2015 Nov 10","pmid":"26247800","title":"Determination of mepitiostane metabolites in human urine by liquid chromatography/tandem mass spectrometry for sports drug testing.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"2014 Aug","pmid":"25082321","title":"[Effect of an oral anti-estrogen agent (mepitiostane) on the regression of intracranial meningiomas in the elderly].","journal":"Brain and nerve = Shinkei kenkyu no shinpo"},{"date":"2001","pmid":"11244236","title":"Unusual annular erythema associated with myelodysplastic syndrome.","journal":"Dermatology (Basel, Switzerland)"},{"date":"2000 Jul","pmid":"10883917","title":"Regression of a presumed meningioma with the antiestrogen agent mepitiostane. Case report.","journal":"Journal of neurosurgery"},{"date":"1994 Apr","pmid":"8058606","title":"A quantitative concept of the mechanism of intestinal lymphatic transfer of lipophilic molecules.","journal":"Pharmaceutical research"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Thioderon (mepitiostane) is a small molecule drug of the mepitiostane class. Its mechanism of action and target are unknown, and it has not been approved by the FDA for any indications. The commercial status of Thioderon is unclear, and it is not known whether it is patented or available as a generic. Further research is needed to determine its safety and efficacy. As a result, Thioderon is not currently a viable treatment option.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}