{"id":"mephenoxalone","rwe":[{"pmid":"11499633","year":"2001","title":"Determination of mephenoxalone in human plasma sample by high-performance liquid chromatography-fluorescence detection.","finding":"","journal":"Journal of chromatography. B, Biomedical sciences and applications","studyType":"Clinical Study"},{"pmid":"10704000","year":"1999","title":"Application of derivative-differential UV spectrophotometry and ratio derivative spectrophotometric determination of mephenoxalone and acetaminophen in combined tablet preparation.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"7562932","year":"1995","title":"Cyclization-activated prodrugs: N-(substituted 2-hydroxyphenyl and 2-hydroxypropyl)carbamates based on ring-opened derivatives of active benzoxazolones and oxazolidinones as mutual prodrugs of acetaminophen.","finding":"","journal":"Journal of medicinal chemistry","studyType":"Clinical Study"},{"pmid":"2577453","year":"1989","title":"Potentiometric and calorimetric assay of mephenoxalone.","finding":"","journal":"Journal of pharmaceutical and biomedical analysis","studyType":"Clinical Study"},{"pmid":"576873","year":"1977","title":"[Isolation and identification of some metabolites of mephenoxalone (Control-OM) from human urine (author's transl)].","finding":"","journal":"Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie","studyType":"Clinical Study"}],"tags":[{"label":"mephenoxalone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"N05BX01","category":"atc"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dorsiflex","offLabel":[],"synonyms":["mephenoxalone","dorsiflex","lenetranat","methoxadone","methoxydon","methoxydone","metoxadon","metoxadone","moderamin","trepidone"],"timeline":[],"approvals":[],"brandName":"Dorsiflex","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mephenoxalone","explanation":"Unfortunately, the exact mechanism of action of Dorsiflex is not well understood, but it is thought to involve the modulation of neural activity to produce its effects. This can lead to changes in the way the brain processes information and responds to stimuli. More research is needed to fully understand how Dorsiflex works.","oneSentence":"Dorsiflex works by interacting with a specific target in the body to produce its therapeutic effect.","technicalDetail":"The technical details of Dorsiflex's mechanism of action are not well-documented, but it is believed to involve the interaction with a specific receptor or enzyme to produce its therapeutic effect."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1693","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MEPHENOXALONE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEPHENOXALONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:34:35.024858","biosimilars":[],"competitors":[],"genericName":"mephenoxalone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[{"nctId":"NCT07233005","phase":"NA","title":"The Effect of Quadriceps Sets Exercise on Knee Joint Biomechanics and Functional Outcomes of Post-Total Knee Arthroplasty Patients","status":"COMPLETED","sponsor":"Cairo University","startDate":"2025-12-01","conditions":["Total Knee Arthroplasty"],"enrollment":36,"completionDate":"2026-03-01"},{"nctId":"NCT06962475","phase":"NA","title":"Randomized Controlled Trial of Custom Foot Orthoses for Chronic Forefoot Pain","status":"RECRUITING","sponsor":"Université du Québec à Trois-Rivières","startDate":"2025-02-01","conditions":["Metatarsalgia"],"enrollment":64,"completionDate":"2027-08-01"},{"nctId":"NCT07062705","phase":"NA","title":"Progressive Inhibition of Neuromuscular Structure and Neural Tissue Mobilization.","status":"NOT_YET_RECRUITING","sponsor":"Riphah International University","startDate":"2025-07-24","conditions":["Lumbar Radiculopathy"],"enrollment":42,"completionDate":"2025-10-20"},{"nctId":"NCT07015658","phase":"NA","title":"Clinical Effects of Moxibustion Combined With Tailored Baduanjin Exercise Programs on Early Postoperative Rehabilitation in Lumbar Disc Herniation Patients Undergoing Minimally Invasive Surgery","status":"NOT_YET_RECRUITING","sponsor":"Suyun Liu","startDate":"2025-06-01","conditions":["Lumbar Disc Herniations"],"enrollment":120,"completionDate":"2026-12-30"},{"nctId":"NCT06134856","phase":"NA","title":"A Study Examining Changes in Pain After Manual Therapy in People With Achilles Tendon Pain","status":"COMPLETED","sponsor":"Philadelphia College of Osteopathic Medicine","startDate":"2023-12-05","conditions":["Achilles Tendinopathy","Ankle Strain","Achilles Tendon Pain","Achilles Tendonitis"],"enrollment":38,"completionDate":"2025-03-05"},{"nctId":"NCT06827574","phase":"NA","title":"Comparative Effects of Sciatic Nerve Flossing and Active Release Technique in Cyclists With Sciatica","status":"ACTIVE_NOT_RECRUITING","sponsor":"Riphah International University","startDate":"2024-04-24","conditions":["Cyclists","Sciatica"],"enrollment":32,"completionDate":"2025-02-15"},{"nctId":"NCT06747741","phase":"NA","title":"Effects of PNF Stretching vs Conventional Physical Therapy on the Symptoms of Restless Leg Syndrome in Elderly Population.","status":"RECRUITING","sponsor":"Foundation University Islamabad","startDate":"2024-06-20","conditions":["Elderly","Restless Leg Syndrome (RLS)","Proprioceptive Neuromuscular Facilitation","Sleep Disturbance"],"enrollment":24,"completionDate":"2024-12-20"},{"nctId":"NCT02616263","phase":"NA","title":"Metatarsal Phalangeal Joint Deformity Progression - 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B, Biomedical sciences and applications"},{"date":"1999 Nov","pmid":"10704000","title":"Application of derivative-differential UV spectrophotometry and ratio derivative spectrophotometric determination of mephenoxalone and acetaminophen in combined tablet preparation.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1995 Sep 29","pmid":"7562932","title":"Cyclization-activated prodrugs: N-(substituted 2-hydroxyphenyl and 2-hydroxypropyl)carbamates based on ring-opened derivatives of active benzoxazolones and oxazolidinones as mutual prodrugs of acetaminophen.","journal":"Journal of medicinal chemistry"},{"date":"1989","pmid":"2577453","title":"Potentiometric and calorimetric assay of mephenoxalone.","journal":"Journal of pharmaceutical and biomedical analysis"},{"date":"1977 Mar","pmid":"576873","title":"[Isolation and identification of some metabolites of mephenoxalone (Control-OM) from human urine (author's transl)].","journal":"Journal of clinical chemistry and clinical biochemistry. Zeitschrift fur klinische Chemie und klinische Biochemie"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dorsiflex is a small molecule modality. It has been studied in clinical trials for various conditions, including Heel Pain Syndrome, Restless Leg Syndrome, and Sleep Disturbance, using interventions such as acupuncture and manual therapy.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}