{"id":"mephenesin-carbamate","rwe":[{"pmid":"3598919","year":"1987","title":"[Antagonist effects of phenprobamate and mephenesin carbamate on deltamethrin poisoning].","finding":"","journal":"Journal de toxicologie clinique et experimentale","studyType":"Clinical Study"},{"pmid":"5806529","year":"1969","title":"The preparation and preliminary pharmacocological evaluation of some oxazolones related to mephenesin carbamate.","finding":"","journal":"Il Farmaco; edizione scientifica","studyType":"Clinical Study"},{"pmid":"5911361","year":"1966","title":"The value of mephenesin carbamate in the control of pain in patients with tic couloureux.","finding":"","journal":"Journal of neurosurgery","studyType":"Clinical Study"},{"pmid":"5866992","year":"1965","title":"Effects of intravenous mephenesin carbamate (Tolseram) on trigeminal antidromic delayed potentials in the cat.","finding":"","journal":"Bulletin of the Los Angeles neurological societies","studyType":"Clinical Study"},{"pmid":"14201603","year":"1964","title":"ACUTE FEBRILE REACTION TO MEPHENESIN CARBAMATE.","finding":"","journal":"JAMA","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Muscle Relaxants, Central","category":"pharmacology"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"unknown","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"tolseram","offLabel":[],"synonyms":["mephenesin carbamate","tolseram"],"timeline":[],"approvals":[],"brandName":"Tolseram","ecosystem":[],"mechanism":{"modality":"Small Molecule","explanation":"Think of it like a volume control for your brain's signals. Tolseram helps to adjust the level of certain chemical messengers, or neurotransmitters, that allow different parts of the brain to communicate with each other. This can help to regulate various bodily functions and behaviors.","oneSentence":"Tolseram works by modulating the activity of certain neurotransmitters in the brain.","technicalDetail":"Tolseram is a carbamate derivative of mephenesin, a central nervous system depressant that acts as a GABA_A receptor agonist, although the exact mechanism of action is not fully understood."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1692","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=mephenesin carbamate","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T15:01:41.431654","biosimilars":[],"competitors":[],"genericName":"mephenesin carbamate","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NDDF":"001668","UNII":"PAD6SXB23N","CHEBI":"CHEBI:134925","INN_ID":"171","RXNORM":"6755","UMLSCUI":"C0025379","DRUGBANK_ID":"DB13583","PUBCHEM_CID":"10775","SNOMEDCT_US":"72522000","MESH_DESCRIPTOR_UI":"D008615"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":14,"therapeuticAreas":["Neuroscience"],"biosimilarFilings":[],"recentPublications":[{"date":"1987 Jan-Feb","pmid":"3598919","title":"[Antagonist effects of phenprobamate and mephenesin carbamate on deltamethrin poisoning].","journal":"Journal de toxicologie clinique et experimentale"},{"date":"1969 Jul","pmid":"5806529","title":"The preparation and preliminary pharmacocological evaluation of some oxazolones related to mephenesin carbamate.","journal":"Il Farmaco; edizione scientifica"},{"date":"1966 Aug","pmid":"5911361","title":"The value of mephenesin carbamate in the control of pain in patients with tic couloureux.","journal":"Journal of neurosurgery"},{"date":"1965 Dec","pmid":"5866992","title":"Effects of intravenous mephenesin carbamate (Tolseram) on trigeminal antidromic delayed potentials in the cat.","journal":"Bulletin of the Los Angeles neurological societies"},{"date":"1964 Nov 23","pmid":"14201603","title":"ACUTE FEBRILE REACTION TO MEPHENESIN CARBAMATE.","journal":"JAMA"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"unknown","modality":"Small Molecule","firstApprovalDate":"","aiSummary":"Tolseram (mephenesin carbamate) is a small molecule modality with unknown drug class and target. Its commercial status is unclear, and it is not known whether it is FDA approved or off-patent. Tolseram is used to treat unknown indications, and its key safety considerations are also unknown. Further research is needed to understand its pharmacology and clinical applications. As a result, it is not possible to provide a comprehensive summary of this medication.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}