{"id":"mephenesin","rwe":[{"pmid":"39749599","year":"2024","title":"[Musical hallucinations: variant of the syndrome of Charles Bonnet?].","finding":"","journal":"Tijdschrift voor psychiatrie","studyType":"Clinical Study"},{"pmid":"39220532","year":"2024","title":"Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.","finding":"","journal":"ACS omega","studyType":"Clinical Study"},{"pmid":"38173535","year":"2024","title":"Investigation of intermolecular interactions of l-Valine and l-Phenylalanine with muscle relaxant drug mephenesin molecule prevalent in aqueous solution by various physico-chemical methods at T=298.15K-313.15K.","finding":"","journal":"Heliyon","studyType":"Clinical Study"},{"pmid":"34762333","year":"2022","title":"Ligand-Free Copper-Catalyzed Ullmann-Type C-O Bond Formation in Non-Innocent Deep Eutectic Solvents under Aerobic Conditions.","finding":"","journal":"ChemSusChem","studyType":"Clinical Study"},{"pmid":"29620696","year":"2018","title":"Mephenesin: Is There a Progression in Cases of Substance Use Related Disorders in France?","finding":"","journal":"Journal of clinical psychopharmacology","studyType":"Clinical Study"}],"tags":[{"label":"mephenesin","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"M03BX06","category":"atc"},{"label":"Active","category":"status"},{"label":"Central Nervous System Agents","category":"pharmacology"},{"label":"Muscle Relaxants, Central","category":"pharmacology"},{"label":"Neuromuscular Agents","category":"pharmacology"},{"label":"Peripheral Nervous System Agents","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"dioloxol","offLabel":[],"synonyms":["mephenesin","cresoxydiol","cresoxypropanediol","dioloxol","memphenesin","mephedan","mephenesine","mephesin","o-Cresyl glycerol ether"],"timeline":[],"approvals":[],"brandName":"Dioloxol","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"mephenesin","explanation":"Think of Dioloxol like a volume control for your brain's signals. It helps to calm down overactive signals that can cause muscle spasms and other symptoms. By adjusting the volume, Dioloxol can help to reduce muscle tension and improve overall comfort.","oneSentence":"Dioloxol works by modulating the central nervous system, although its exact target is unknown.","technicalDetail":"Dioloxol is a GABA-mimetic agent, which means it works by mimicking the action of the neurotransmitter gamma-aminobutyric acid (GABA) in the central nervous system. GABA is an inhibitory neurotransmitter that helps to calm down or reduce the activity of neurons, and Dioloxol's mechanism of action is thought to involve the enhancement of GABAergic activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1691","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MEPHENESIN","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:34:31.485993","biosimilars":[],"competitors":[{"drugName":"baclofen","drugSlug":"baclofen","fdaApproval":"1977-11-22","patentExpiry":"Sep 8, 2037","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"tizanidine","drugSlug":"tizanidine","fdaApproval":"1996-11-27","patentExpiry":"May 7, 2042","patentStatus":"Patent protected","relationship":"same-class"},{"drugName":"cyclobenzaprine","drugSlug":"cyclobenzaprine","fdaApproval":"1977-08-26","patentExpiry":"Mar 14, 2034","patentStatus":"Patent protected","relationship":"same-class"}],"genericName":"mephenesin","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"baclofen","brandName":"baclofen","genericName":"baclofen","approvalYear":"1977","relationship":"same-class"},{"drugId":"tizanidine","brandName":"tizanidine","genericName":"tizanidine","approvalYear":"1996","relationship":"same-class"},{"drugId":"cyclobenzaprine","brandName":"cyclobenzaprine","genericName":"cyclobenzaprine","approvalYear":"1977","relationship":"same-class"}],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"NUI":"N0000166815","NDDF":"001668","UNII":"7B8PIR2954","CHEBI":"CHEBI:94398","INN_ID":"171","RXNORM":"6755","UMLSCUI":"C0025379","ChEMBL_ID":"CHEMBL229128","KEGG_DRUG":"D02595","DRUGBANK_ID":"DB13583","PUBCHEM_CID":"4059","SNOMEDCT_US":"72522000","MESH_DESCRIPTOR_UI":"D008615"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":410,"therapeuticAreas":["Neuroscience"],"atcClassification":{"source":"DrugCentral","atcCode":"M03BX06","allCodes":["M03BX06"]},"biosimilarFilings":[],"recentPublications":[{"date":"2024","pmid":"39749599","title":"[Musical hallucinations: variant of the syndrome of Charles Bonnet?].","journal":"Tijdschrift voor psychiatrie"},{"date":"2024 Aug 27","pmid":"39220532","title":"Investigation of Host-Guest Inclusion Complex of Mephenesin with α-Cyclodextrin for Innovative Application in Biological System.","journal":"ACS omega"},{"date":"2024 Jan 15","pmid":"38173535","title":"Investigation of intermolecular interactions of l-Valine and l-Phenylalanine with muscle relaxant drug mephenesin molecule prevalent in aqueous solution by various physico-chemical methods at T=298.15K-313.15K.","journal":"Heliyon"},{"date":"2022 Jan 10","pmid":"34762333","title":"Ligand-Free Copper-Catalyzed Ullmann-Type C-O Bond Formation in Non-Innocent Deep Eutectic Solvents under Aerobic Conditions.","journal":"ChemSusChem"},{"date":"2018 Jun","pmid":"29620696","title":"Mephenesin: Is There a Progression in Cases of Substance Use Related Disorders in France?","journal":"Journal of clinical psychopharmacology"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Dioloxol is a small molecule with the synonyms DECONTRACTYL, MEFENESINA, MEPHENESIN, and MEPHENESINE.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}