{"id":"meniscal-allograft","safety":{"commonSideEffects":[{"rate":null,"effect":"Graft failure or resorption"},{"rate":null,"effect":"Infection"},{"rate":null,"effect":"Knee pain or swelling"},{"rate":null,"effect":"Limited range of motion"}]},"_chembl":null,"_dailymed":null,"mechanism":{"_ai_source":"claude-haiku-4.5","explanation":"Meniscal allografts are cadaveric meniscal tissues surgically implanted into the knee joint to restore the structural and biomechanical function of a damaged meniscus. The allograft acts as a biological spacer and shock absorber, distributing load across the knee joint and protecting the articular cartilage from degenerative changes. This procedure aims to delay or prevent osteoarthritis progression in patients with meniscal deficiency.","oneSentence":"A meniscal allograft is a transplanted human meniscus tissue that replaces a damaged or missing meniscus to restore knee joint function and reduce pain.","_ai_confidence":"medium"},"_scrapedAt":"2026-03-28T01:20:48.147Z","_scrapedBy":"cloudflare-swarm","_wikipedia":null,"indications":{"approved":[{"name":"Meniscal deficiency or irreparable meniscal tears in the knee joint"}]},"trialDetails":[{"nctId":"NCT04903106","phase":"","title":"Safety and Performance Study of the FAST-FIX FLEX System for Meniscal Repairs and Meniscal Transplantations","status":"COMPLETED","sponsor":"Smith & Nephew, Inc.","startDate":"2022-01-20","conditions":"Meniscus Tear","enrollment":63},{"nctId":"NCT05840887","phase":"NA","title":"Knee Osteotomy Associated With Allograft Meniscus Transplantation","status":"RECRUITING","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2023-08-30","conditions":"Malalignment, Bone, Osteoarthritis, Knee","enrollment":52},{"nctId":"NCT07204587","phase":"NA","title":"Semitendinosus Autograft vs Meniscal Allograft in Post-Meniscectomy Syndrome","status":"NOT_YET_RECRUITING","sponsor":"Chang Gung Memorial Hospital","startDate":"2025-10-01","conditions":"Meniscal Injuries, Meniscal Tear, Meniscus Lesion","enrollment":40},{"nctId":"NCT06522152","phase":"","title":"Evaluation of Clinical-functional and Radiographic Outcomes in Patients Who Underwent Meniscal Allograft Transplantation (MAT) at 10 Years.","status":"RECRUITING","sponsor":"Istituto Ortopedico Rizzoli","startDate":"2024-10-24","conditions":"Meniscus Disorder, Arthritis Knee","enrollment":397},{"nctId":"NCT06376422","phase":"NA","title":"Sterile Allogeneic Spongioflex® Allograft as Partial Meniscal Replacement After Incomplete Meniscal Loss","status":"RECRUITING","sponsor":"Sven Behrendt","startDate":"2024-04-30","conditions":"Meniscus Lesion","enrollment":40},{"nctId":"NCT02503228","phase":"","title":"Clinical Registry Assessment of the Missouri Osteochondral Allograft Preservation System - MOPS","status":"ENROLLING_BY_INVITATION","sponsor":"University of Missouri-Columbia","startDate":"2015-06","conditions":"Symptomatic Osteochondral Defect(s), Cartilage, Meniscus, Ankle, Knee, Shoulder, Hip","enrollment":5000},{"nctId":"NCT05412615","phase":"NA","title":"PRC With Meniscal Allograft Arthroplasty for Wrist Osteoarthritis","status":"RECRUITING","sponsor":"University of Colorado, Denver","startDate":"2023-09-01","conditions":"Wrist Osteoarthritis","enrollment":20},{"nctId":"NCT06775197","phase":"PHASE4","title":"Partial Meniscal Replacement with Spongioflex®","status":"RECRUITING","sponsor":"Maria-Josef-Hospital Greven","startDate":"2024-11-05","conditions":"Partial Meniscal Loss, Lateral Meniscus Partial Loss, Medial Meniscal Partial Loss","enrollment":40},{"nctId":"NCT06749431","phase":"","title":"Clinical Outcomes, Graft Longevity, and Chondral Protection Following Primary or Revision Meniscal Allograft Transplantation Surgery","status":"ENROLLING_BY_INVITATION","sponsor":"Joint Restoration Foundation, Inc.","startDate":"2025-01-05","conditions":"Meniscus Tear, Meniscus Disorder, Patient Satisfaction","enrollment":5000},{"nctId":"NCT01059409","phase":"NA","title":"Study of Meniscal Allografts","status":"TERMINATED","sponsor":"Assistance Publique - Hôpitaux de Paris","startDate":"2010-09","conditions":"Meniscectomy Sequelae","enrollment":23},{"nctId":"NCT00659880","phase":"","title":"Clinical Application of BioCleanse Meniscus","status":"COMPLETED","sponsor":"RTI Surgical","startDate":"2008-04","conditions":"Tear of Meniscus of Knee","enrollment":9},{"nctId":"NCT01673347","phase":"PHASE3","title":"Allograft Transplantation in the Treatment of Osteoarthritis of the Metatarsophalangeal (MTP) Joint of the Great Toe","status":"COMPLETED","sponsor":"Paul Fortin, MD","startDate":"2010-09","conditions":"Osteoarthritis","enrollment":24},{"nctId":"NCT01542515","phase":"","title":"Allograft Meniscal Arthroplasty for the Treatment of Basal Joint Arthritis of the Thumb","status":"COMPLETED","sponsor":"Corewell Health East","startDate":"2009-03","conditions":"Arthritis","enrollment":22}],"_emaApprovals":[],"_faersSignals":[],"_approvalHistory":[],"publicationCount":609,"rwe":[],"genericFilers":[],"relatedDrugs":[],"labelChanges":[],"biosimilarFilings":[],"pricing":[],"formularyStatus":[],"manufacturing":[],"companionDiagnostics":[],"competitors":[],"timeline":[],"patents":[],"ownershipHistory":[],"trials":[],"biosimilars":[],"latestUpdates":[],"references":[],"tags":[],"ecosystem":[],"genericManufacturerList":[],"offLabel":[],"developmentCodes":[],"aliases":["Musculoskeletal Transplant Foundation","Meniscal transplant"],"phase":"phase_3","status":"active","brandName":"Meniscal Allograft","genericName":"Meniscal Allograft","companyName":"Paul Fortin, MD","companyId":"paul-fortin-md","modality":"Biologic","firstApprovalDate":"","aiSummary":"A meniscal allograft is a transplanted human meniscus tissue that replaces a damaged or missing meniscus to restore knee joint function and reduce pain. Used for Meniscal deficiency or irreparable meniscal tears in the knee joint.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"verified","dataCompleteness":{"mechanism":true,"indications":true,"safety":true,"trials":true,"score":4}}