{"id":"menbutone","rwe":[{"pmid":"39272325","year":"2024","title":"Pharmacokinetic Pattern of Menbutone in Calves after Single Intravenous and Intramuscular Administration.","finding":"","journal":"Animals : an open access journal from MDPI","studyType":"Clinical Study"},{"pmid":"36165420","year":"2022","title":"Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning.","finding":"","journal":"Australian veterinary journal","studyType":"Clinical Study"},{"pmid":"36003407","year":"2022","title":"Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep.","finding":"","journal":"Frontiers in veterinary science","studyType":"Clinical Study"},{"pmid":"35203171","year":"2022","title":"Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep.","finding":"","journal":"Animals : an open access journal from MDPI","studyType":"Clinical Study"},{"pmid":"33448662","year":"2021","title":"Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents.","finding":"","journal":"Chemistry & biodiversity","studyType":"Clinical Study"}],"tags":[{"label":"menbutone","category":"class"},{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"menbuton","offLabel":[],"synonyms":["menbutone","genabilic acid","genabilin","menbuton","naftobil","menbutone sodium"],"timeline":[],"approvals":[],"brandName":"Menbuton","ecosystem":[],"mechanism":{"modality":"Small Molecule","drugClass":"menbutone","explanation":"Think of it like a car engine: Menbutone blocks a key part of the engine that helps it run, which can slow down or stop the growth of certain cells. This can be helpful in treating diseases where cells are growing too quickly. However, it's essential to be cautious when using Menbutone because it can also affect healthy cells.","oneSentence":"Menbutone works by inhibiting an enzyme involved in cellular energy production.","technicalDetail":"Menbutone is a competitive inhibitor of succinate dehydrogenase, an enzyme involved in the electron transport chain and the citric acid cycle, which are critical for cellular energy production."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/3338","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MENBUTONE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T12:34:20.658275","biosimilars":[],"competitors":[],"genericName":"menbutone","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[],"trialDetails":[],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"crossReferences":{"UNII":"341YM32546","CHEBI":"CHEBI:135064","INN_ID":"2303","UMLSCUI":"C0065938","ChEMBL_ID":"CHEMBL1972268","KEGG_DRUG":"D08178","PUBCHEM_CID":"71818","SECONDARY_CAS_RN":"111961-03-6","MESH_SUPPLEMENTAL_RECORD_UI":"C011497"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":7,"therapeuticAreas":["Other"],"biosimilarFilings":[],"recentPublications":[{"date":"2024 Aug 31","pmid":"39272325","title":"Pharmacokinetic Pattern of Menbutone in Calves after Single Intravenous and Intramuscular Administration.","journal":"Animals : an open access journal from MDPI"},{"date":"2022 Dec","pmid":"36165420","title":"Comparing the effect of ammonium molybdate versus ammonium molybdate and menbutone on hepatic functions of sheep with subclinical copper poisoning.","journal":"Australian veterinary journal"},{"date":"2022","pmid":"36003407","title":"Pharmacokinetics of menbutone after intravenous and intramuscular administration to sheep.","journal":"Frontiers in veterinary science"},{"date":"2022 Feb 14","pmid":"35203171","title":"Improvement of Albendazole Bioavailability with Menbutone Administration in Sheep.","journal":"Animals : an open access journal from MDPI"},{"date":"2021 Feb","pmid":"33448662","title":"Multi-Targeting Tacrine Conjugates with Cholinesterase and Amyloid-Beta Inhibitory Activities: New Anti-Alzheimer's Agents.","journal":"Chemistry & biodiversity"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Menbuton is a small molecule. It is also known by the synonyms GENABILIC ACID, GENABILIN, GENABILINE, MENBUTONA, MENBUTONE, and NSC-53969.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":false,"score":1}}