{"id":"menadione-sodium-bisulfite","rwe":[{"pmid":"41745289","year":"2026","title":"Low-Intensity, Short-Duration Proton Irradiation Enhances Oxidative Stress Sensitivity of Aspergillus nidulans, with Transcriptomic Data Indicating Downregulation of Antioxidative Enzyme Genes.","finding":"","journal":"Journal of fungi (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41304936","year":"2025","title":"From Single-Cell and Bulk Transcriptomic Integration to Functional Verification: Triaptosis-Associated lncRNA Signature Predicts Survival and Guides Therapy in Hepatocellular Carcinoma.","finding":"","journal":"Pharmaceuticals (Basel, Switzerland)","studyType":"Clinical Study"},{"pmid":"41023824","year":"2025","title":"The MeaB bZIP transcription factor is needed for proper nitrosative stress response induced by nitrite in Aspergillus fumigatus.","finding":"","journal":"BMC genomics","studyType":"Clinical Study"},{"pmid":"40429949","year":"2025","title":"Effect of Warfarin on Lifespan and Oxidative Stress Tolerance of Drosophila melanogaster.","finding":"","journal":"International journal of molecular sciences","studyType":"Clinical Study"},{"pmid":"40190674","year":"2024","title":"Green Formulation of Menadione-Loaded Niosome as a Skin-Lightening Preparation: In Vitro /In Vivo Safety Evaluation on Wistar Rat.","finding":"","journal":"Advanced pharmaceutical bulletin","studyType":"Clinical Study"}],"tags":[{"label":"Small Molecule","category":"modality"},{"label":"Active","category":"status"},{"label":"Antifibrinolytic Agents","category":"pharmacology"},{"label":"Coagulants","category":"pharmacology"},{"label":"Hematologic Agents","category":"pharmacology"},{"label":"Hemostatics","category":"pharmacology"},{"label":"Micronutrients","category":"pharmacology"},{"label":"Vitamins","category":"pharmacology"}],"phase":"phase_2","safety":{},"trials":[],"aliases":[],"patents":[],"pricing":[],"allNames":"vikasolum","offLabel":[],"synonyms":["menadione sodium bisulfite","vikasolum","menadione sodium hydrogen sulfite","menaphthone sodium bisulfite","menaphthone sodium bisulphite","sodium menadione bisulfite","Vitamin K3 sodium bisulfite"],"timeline":[],"approvals":[],"brandName":"Vikasolum","ecosystem":[],"mechanism":{"target":"Aldose reductase","modality":"Small Molecule","explanation":"Think of vitamin K-dependent proteins like the locks on a door. Vikasolum helps keep these locks stable, allowing them to function properly. This is important because these proteins play a crucial role in blood clotting and other bodily processes.","oneSentence":"Vikasolum works by interacting with and stabilizing vitamin K-dependent proteins in the body.","technicalDetail":"Menadione Sodium Bisulfite is a synthetic derivative of vitamin K3, which acts as a co-factor for vitamin K-dependent carboxylases, facilitating the post-translational modification of target proteins and maintaining their activity."},"commercial":{},"references":[{"id":1,"url":"https://drugcentral.org/drugcard/1684","fields":["approvals","synonyms","ATC","PK","indications","contraindications","DDIs","targets","patents","FAERS"],"source":"DrugCentral"},{"id":2,"url":"https://clinicaltrials.gov/search?intr=MENADIONE%20SODIUM%20BISULFITE","fields":["trials"],"source":"ClinicalTrials.gov"},{"id":3,"url":"https://pubmed.ncbi.nlm.nih.gov/?term=MENADIONE SODIUM BISULFITE","fields":["publications"],"source":"PubMed/NCBI"}],"_enrichedAt":"2026-03-30T14:18:39.449989","biosimilars":[],"competitors":[{"drugName":"aceclofenac","drugSlug":"aceclofenac","fdaApproval":"","relationship":"same-target"},{"drugName":"chlorambucil","drugSlug":"chlorambucil","fdaApproval":"1957-03-18","patentStatus":"Unknown","relationship":"same-target"},{"drugName":"dicoumarol","drugSlug":"dicoumarol","fdaApproval":"1944-07-31","relationship":"same-target"},{"drugName":"ethacrynic acid","drugSlug":"ethacrynic-acid","fdaApproval":"1967-01-10","genericCount":10,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"indomethacin","drugSlug":"indomethacin","fdaApproval":"1965-06-10","patentExpiry":"Apr 23, 2030","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"ketorolac","drugSlug":"ketorolac","fdaApproval":"1989-11-30","patentExpiry":"Nov 24, 2027","patentStatus":"Patent protected","relationship":"same-target"},{"drugName":"pioglitazone","drugSlug":"pioglitazone","fdaApproval":"1999-07-15","genericCount":13,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"polydatin","drugSlug":"polydatin","fdaApproval":"","relationship":"same-target"},{"drugName":"sulfasalazine","drugSlug":"sulfasalazine","fdaApproval":"1950-06-20","genericCount":8,"patentStatus":"Off-patent — generic available","relationship":"same-target"},{"drugName":"sulindac","drugSlug":"sulindac","fdaApproval":"1978-09-27","genericCount":7,"patentStatus":"Off-patent — generic available","relationship":"same-target"}],"dataSources":[{"url":"https://drugcentral.org","name":"DrugCentral","fields":["indications","contraindications","safety","target","drugInteractions"],"retrievedDate":"2026-04-07"}],"genericName":"menadione sodium bisulfite","indications":{"approved":[],"offLabel":[],"pipeline":[]},"drugCategory":"active","labelChanges":[],"relatedDrugs":[{"drugId":"aceclofenac","brandName":"aceclofenac","genericName":"aceclofenac","approvalYear":"","relationship":"same-target"},{"drugId":"chlorambucil","brandName":"chlorambucil","genericName":"chlorambucil","approvalYear":"1957","relationship":"same-target"},{"drugId":"dicoumarol","brandName":"dicoumarol","genericName":"dicoumarol","approvalYear":"1944","relationship":"same-target"},{"drugId":"ethacrynic-acid","brandName":"ethacrynic acid","genericName":"ethacrynic acid","approvalYear":"1967","relationship":"same-target"},{"drugId":"indomethacin","brandName":"indomethacin","genericName":"indomethacin","approvalYear":"1965","relationship":"same-target"},{"drugId":"ketorolac","brandName":"ketorolac","genericName":"ketorolac","approvalYear":"1989","relationship":"same-target"},{"drugId":"pioglitazone","brandName":"pioglitazone","genericName":"pioglitazone","approvalYear":"1999","relationship":"same-target"},{"drugId":"polydatin","brandName":"polydatin","genericName":"polydatin","approvalYear":"","relationship":"same-target"},{"drugId":"sulfasalazine","brandName":"sulfasalazine","genericName":"sulfasalazine","approvalYear":"1950","relationship":"same-target"},{"drugId":"sulindac","brandName":"sulindac","genericName":"sulindac","approvalYear":"1978","relationship":"same-target"}],"trialDetails":[{"nctId":"NCT01393821","phase":"NA","title":"Menadione Topical Lotion in Treating Skin Discomfort and Psychological Distress in Patients With Cancer Receiving Panitumumab, Erlotinib Hydrochloride, or Cetuximab","status":"COMPLETED","sponsor":"Mayo Clinic","startDate":"2012-01-23","conditions":["Dermatologic Complications","Malignant Neoplasm","Pain"],"enrollment":27,"completionDate":"2018-07-14"},{"nctId":"NCT00656786","phase":"PHASE1","title":"Safety, Tolerability and Systemic Absorption of Menadione Topical Lotion for Epidermal-Growth-Factor-Receptor (EGFR) Inhibitor-Associated Rash","status":"COMPLETED","sponsor":"Spectrum Pharmaceuticals, Inc","startDate":"2008-04-03","conditions":["EGFR Inhibitor-associated Rash"],"enrollment":18,"completionDate":"2009-12-30"}],"genericFilers":[],"latestUpdates":[],"manufacturing":[],"administration":{},"crossReferences":{"NDDF":"001041","UNII":"6XF3C2HK77","CHEBI":"CHEBI:63928","RXNORM":"52551","UMLSCUI":"C0127516","ChEMBL_ID":"CHEMBL2107211","KEGG_DRUG":"D08177","DRUGBANK_ID":"DB15944","PUBCHEM_CID":"23665888","SNOMEDCT_US":"708600008","SECONDARY_CAS_RN":"6147-37-1","MESH_DESCRIPTOR_UI":"D024483"},"formularyStatus":[],"_enricherVersion":"v2","developmentCodes":[],"ownershipHistory":[],"publicationCount":89,"therapeuticAreas":["Hematology"],"biosimilarFilings":[],"recentPublications":[{"date":"2026 Feb 19","pmid":"41745289","title":"Low-Intensity, Short-Duration Proton Irradiation Enhances Oxidative Stress Sensitivity of Aspergillus nidulans, with Transcriptomic Data Indicating Downregulation of Antioxidative Enzyme Genes.","journal":"Journal of fungi (Basel, Switzerland)"},{"date":"2025 Nov 7","pmid":"41304936","title":"From Single-Cell and Bulk Transcriptomic Integration to Functional Verification: Triaptosis-Associated lncRNA Signature Predicts Survival and Guides Therapy in Hepatocellular Carcinoma.","journal":"Pharmaceuticals (Basel, Switzerland)"},{"date":"2025 Sep 29","pmid":"41023824","title":"The MeaB bZIP transcription factor is needed for proper nitrosative stress response induced by nitrite in Aspergillus fumigatus.","journal":"BMC genomics"},{"date":"2025 May 17","pmid":"40429949","title":"Effect of Warfarin on Lifespan and Oxidative Stress Tolerance of Drosophila melanogaster.","journal":"International journal of molecular sciences"},{"date":"2024 Dec 30","pmid":"40190674","title":"Green Formulation of Menadione-Loaded Niosome as a Skin-Lightening Preparation: In Vitro /In Vivo Safety Evaluation on Wistar Rat.","journal":"Advanced pharmaceutical bulletin"}],"companionDiagnostics":[],"genericManufacturerList":[],"status":"active","companyName":"","companyId":"","modality":"Small molecule","firstApprovalDate":"","aiSummary":"Vikasolum, also known as Menadione Sodium Bisulfite, is a small molecule drug with unknown target and drug class. Its commercial status is unclear, and it has not been approved by the FDA for any indications. As a small molecule, it is likely to work by interacting with specific biological pathways, but the exact mechanism is unknown. Further research is needed to understand its potential therapeutic applications and safety profile.","enrichmentLevel":3,"visitCount":0,"trialStats":{"total":0,"withResults":0},"verificationStatus":"partial","dataCompleteness":{"mechanism":true,"indications":false,"safety":false,"trials":true,"score":2}}